8期

最新文章

• A binary trait model reveals the fitness effects of HIV-1 escape from T cell responses AI翻译
  作者：Gao, Yirui; Barton, John P.
  作者单位：University of California System; University of California Riverside; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh
  摘要：Natural selection often acts on multiple traits simultaneously. For example, the virus HIV-1 faces pressure to evade host immunity while also preserving replicative fitness. While past work has studied selection during HIV-1 evolution, as in other examples where selection acts on multiple traits, it is challenging to quantitatively separate different contributions to fitness. This task is made more difficult because a single mutation can affect both immune escape and replication. Here, we deve...
• Profile of Mark Kirkpatrick AI翻译
  作者：Ravindran, Sandeep
• Volumetric imaging of the 3D orientation of cellular structures with a polarized fluorescence light-sheet microscope AI翻译
  作者：Chandler, Talon; Guo, Min; Su, Yijun; Chen, Jiji; Wu, Yicong; Liu, Junyu; Agashe, Atharva; Fischer, Robert S.; Mehta, Shalin B.; Kumar, Abhishek; Baskin, Tobias I.; Jaumouille, Valentin; Liu, Huafeng; Swaminathan, Vinay; Nain, Amrinder S.; Oldenbourg, Rudolf; La Riviere, Patrick J.; Shroff, Hari
  作者单位：Chan Zuckerberg Initiative (CZI); University of Chicago; Zhejiang University; National Institutes of Health (NIH) - USA; NIH National Institute of Biomedical Imaging & Bioengineering (NIBIB); National Institutes of Health (NIH) - USA; Howard Hughes Medical Institute; Virginia Polytechnic Institute & State University; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI); Marine Biological Laboratory - Woods Hole; University of Massachusetts System; University of Massachusetts Amherst; Marine Biological Laboratory - Woods Hole; Simon Fraser University; Scania; Lund University; Lund University; Scania
  摘要：Polarized fluorescence microscopy is a valuable tool for measuring molecular orientations in biological samples, but techniques for recovering three-dimensional orientations and positions of fluorescent ensembles are limited. We report a polarized dual-view light-sheet system for determining the diffraction-limited three-dimensional distribution of the orientations and positions of ensembles of fluorescent dipoles that label biological structures. We share a set of visualization, histogram, an...
• OsNLP3 and OsPHR2 orchestrate direct and mycorrhizal pathways for nitrate uptake by regulating NAR2.1-NRT2s complexes in rice AI翻译
  作者：Wang, Shuangshuang; Ye, Hanghang; Yang, Congfan; Zhang, Yan; Pu, Jiawen; Ren, Yuhan; Xie, Kun; Wang, Lingxiao; Zeng, Dechao; He, Haoqiang; Ji, Haoyan; Herrera-Estrella, Luis Rafael; Xu, Guohua; Chen, Aiqun
  作者单位：Nanjing Agricultural University; Texas Tech University System; Texas Tech University; Instituto Politecnico Nacional - Mexico; CINVESTAV - Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional; Nanjing Agricultural University
  摘要：Nitrogen (N) is the most important essential nutrient required by plants. Most land plants have evolved two N uptake pathways, a direct root pathway and a symbiotic pathway, via association with arbuscular mycorrhizal (AM) fungi. However, the interaction between the two pathways is ambiguous. Here, we report that OsNAR2.1-OsNRT2s, the nitrate (NO3-) transporter complexes with crucial roles in direct NO3 - uptake, are also recruited for symbiotic NO3- uptake. OsNAR2.1 and OsNRT2.1/2.2 are coreg...
• PSKH1 kinase activity is differentially modulated via allosteric binding of Ca2+sensor proteins AI翻译
  作者：Horne, Christopher R.; Dite, Toby A.; Young, Samuel N.; Mather, Lucy J.; Dagley, Laura F.; Johnson, Jared L.; Yaron-Barir, Tomer M.; Huntsman, Emily M.; Daly, Leonard A.; Byrne, Dominic P.; Cadell, Antonia L.; Ng, Boaz H.; Yousef, Jumana; Multari, Dylan H.; Shen, Lianju; Mcaloon, Luke M.; Manning, Gerard; Febbraio, Mark A.; Means, Anthony R.; Cantley, Lewis C.; Tanzer, Maria C.; Croucher, David R.; Eyers, Claire E.; Eyers, Patrick A.; Scott, John W.; Murphy, James M.
  作者单位：Walter & Eliza Hall Institute; University of Melbourne; Monash University; Cornell University; Weill Cornell Medicine; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard Medical School; Cornell University; Weill Cornell Medicine; Columbia University; University of Liverpool; University of Liverpool; Garvan Institute of Medical Research; Australian Catholic University; St. Vincent's Institute of Medical Research; Baylor College of Medicine; University of New South Wales Sydney; Florey Institute of Neuroscience & Mental Health
  摘要：Protein Serine Kinase H1 (PSKH1) was recently identified as a crucial factor in kidney development and is overexpressed in prostate, lung, and kidney cancers. However, little is known about PSKH1 regulatory mechanisms, leading to its classification as a dark kinase. Here, we used biochemistry and mass spectrometry to define PSKH1's consensus substrate motif, protein interactors, and how interactors, including Ca2+ sensor proteins, promote or suppress activity. Intriguingly, despite the absence...
• Fungal- derived methyldeoxaphomins target Plasmodium falciparum segregation through the inhibition of PfActin1 AI翻译
  作者：Jiang, Tiantian; Lee, Jin Woo; Collins, Jennifer E.; Schaefer, Samuel; Chen, Daisy; Nardella, Flore; Wendt, Karen; Peramuna, Thilini G.; Paes, Raphaella; Mclellan, James L.; Bhasin, Jasveen; Durst, Gregory L.; Hanson, Kirsten K.; Chakrabarti, Debopam; Cichewicz, Robert H.; Winzeler, Elizabeth A.
  作者单位：University of California System; University of California San Diego; Duksung Women's University; State University System of Florida; University of Central Florida; University of Michigan System; University of Michigan; University of Texas System; University of Texas at San Antonio; University of California System; University of California San Diego
  摘要：Herein we report the finding and structure determination of a natural product based on the methyldeoxaphomin scaffold family from the fungus Trichocladium asperum that shows promising antiplasmodial activity and selectivity against host cells. In vitro evolution and whole genome analysis in Plasmodium falciparum with shows that parasite resistance to methyldeoxaphomins is strongly associated with mutations in PfActin1 (PF3D7_1246200), a critically essential ATPase needed for all stages of para...
• Druggable genome screens identify SPP as an antiviral host target for multiple flaviviruses AI翻译
  作者：Qiao, Wenjie; Xie, Xuping; Shi, Pei-Yong; Ooi, Yaw Shin; Carette, Jan E.
  作者单位：Stanford University; University of Texas System; University of Texas Medical Branch Galveston; University of Texas System; University of Texas Medical Branch Galveston; National University of Singapore; Agency for Science Technology & Research (A*STAR); A*STAR Infectious Diseases Labs (A*STAR IDL)
  摘要：Mosquito- borne flaviviruses, such as dengue virus (DENV), Zika virus (ZIKV), West Nile virus, and yellow fever virus, pose significant public health threats globally. Extensive efforts have led to the development of promising highly active compounds against DENV targeting viral non- structural protein 4B (NS4B) protein. However, due to the cocirculation of flaviviruses and to prepare for emerging flaviviruses, there is a need for more broadly acting antivirals. Host- directed therapy where on...
• Manipulating hydrogenation pathways enables economically viable electrocatalytic aldehyde- to- alcohol valorization AI翻译
  作者：Yao, Ze-Cheng; Chai, Jing; Tang, Tang; Ding, Liang; Jiang, Zhe; Fu, Jiaju; Chang, Xiaoxia; Xu, Bingjun; Zhang, Liang; Hu, Jin-Song; Wan, Li-Jun
  作者单位：Chinese Academy of Sciences; Institute of Chemistry, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Tsinghua University; Peking University
  摘要：Electrocatalytic reduction (ECR) of furfural represents a sustainable route for biomass product distribution and industrial- incompatible production rates, mainly caused by the intricate mechanism-performance relationship. Here, we manipulate hydrogenation pathways on Cu by introducing ceria as an auxiliary component, which enables the mechanism switching from proton- coupled electron transfer to electrochemical hydrogen- atom transfer (HAT) and thus high- speed furfural- to- furfuryl alcohol ...
• Options for student loan repayment matter AI翻译
  作者：Abraham, Katharine G.
  作者单位：University System of Maryland; University of Maryland College Park
• Risks of habitat loss from seaweed cultivation within seagrass AI翻译
  作者：Jones, Benjamin L. H.; Eklof, Johan S.; Unsworth, Richard K. F.; Coals, Lucy; Christianen, Marjolijn J. A.; Clifton, Julian; Unsworth, Leanne C. Cullen-; Castro, Maricela de la Torre-; Esteban, Nicole; Huxham, Mark; Jiddawi, Narriman S.; Mckenzie, Len J.; Nakaoka, Masahiro; Nordlund, Lina M.; Ooi, Jillian L. S.; Prathep, Anchana
  作者单位：State University System of Florida; Florida International University; Stockholm University; Swansea University; Deakin University; Wageningen University & Research; Curtin University; Stockholm University; Edinburgh Napier University; University of Dar es Salaam; James Cook University; Hokkaido University; Uppsala University; Universiti Malaya; Prince of Songkla University