-
作者：Kamatani, Tomoki; Kimura, Reiko; Ikeda, Satoshi; Inoue, Makoto; Seino, Ken-ichiro
作者单位：Hokkaido University
摘要：Currently, most cell or tissue transplantations using induced pluripotent stem cells (iPSCs) are anticipated to involve allogeneic iPSCs. However, the immunological properties of iPSCs in an allogeneic setting are not well understood. previously established a mouse transplantation model of MHC-compatible/minor antigen-mismatched combinations, assuming a hypoimmunogenic iPSC-setting. Here, we found that iPSCs subcutaneously inoculated into MHC-compatible geneic host mice resisted rejection and ...
-
作者：Leshin, Rachel A.; Benitez, Josie; Fu, Serena; Cordeiro, Sophia; Rhodes, Marjorie
作者单位：Princeton University; New York University
摘要：Adults tend to view men (more so than women) as default people, with numerous real-world consequences for gender equity. In the United States, the tendency to center men in concepts of people develops across middle childhood, yet the specific mechanisms that contribute to it remain unknown. Here, we investigate one subtle but potentially powerful social mechanism: the category labels that parents use to describe boys/men and girls/women in conversations with their children. Across two studies ...
-
作者：Ruggles, Steven
作者单位：University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities
摘要：U.S. Census Bureau officials recently reaffirmed the Bureau's ongoing efforts to replace the American Community Survey (ACS) public use microdata sample with fully synthetic data to protect respondent confidentiality. With the growth of computing power and expansion of private sector data about the population, the Census Bureau has valid concerns about confidentiality threats to public data. The current plan for fully synthetic data, however, threatens a cornerstone of the nation's scientific ...
-
作者：Xiao, Yu; Zhang, Xiaohan; Guo, Siwei; Liu, Ziyi; Zhao, Xiaoxu; Dong, Fengyue; Bi, Xiuli; Hong, Guodong; Chang, Miao; Qiao, Ruifeng; Cao, Shengda; Liu, Ying; Xia, Ming; Yuan, Wei; Zhang, Jing; Li, Wen; Zhu, Liya; Chai, Renjie; Gao, Jiangang; Fu, Xiaolong
作者单位：Shandong University; Shandong First Medical University & Shandong Academy of Medical Sciences; Shandong University; Shandong University; Southeast University - China; Beijing Institute of Technology; Beijing Institute of Technology; Nantong University; University of Electronic Science & Technology of China; Sichuan Provincial People's Hospital; Southeast University - China
摘要：Inflammation is among the known causes of cisplatin-induced hearing loss (CIHL), but its exact pathophysiological mechanisms remain unclear. Herein, we demonstrated that pyroptosis-a recently identified inflammatory type of regulated cell death dependent on gasdermin D (GSDMD)-was activated in the cochleae of cisplatin-treated mice, causing CIHL. Meanwhile, treatment with the GSDMD inhibitor necrosulfonamide alleviated CIHL in these mice. To further examine the role of GSDMD-mediated pyroptosi...
-
作者：Chisholm, Paul J.; Gray, Andrew N.
作者单位：United States Department of Agriculture (USDA); United States Forest Service
摘要：Large-diameter trees provide vital ecological functions in forested ecosystems. Old, large-diameter trees may also be vulnerable to climate-driven mortality events, but past work on large tree populations has been geographically limited. Here, we characterize the population of large-diameter trees from two size categories, 50 to 100 cm diameter at breast height (DBH) (medium) and >100 cm DBH (big), within the United States using Forest Inventory and Analysis data. Although populations of big t...
-
作者：Vani, Nathan; Ibarra, Alejandro; Bico, Jose; Reyssat, Etienne; Roman, Benoit
作者单位：Sorbonne Universite; Universite PSL; Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI); Universite Paris Cite
摘要：We investigate the mechanics of two asymmetric ribbons bound at one end and pulled apart at the other ends. We characterize the elastic junction near the bonding and conceptualize it as a bending boundary layer. While the size of this junction decreases with the pulling force, we observe the surprising existence of the binding angle as a macroscopic signature of the bending stiffnesses. Our results thus challenge the standard assumption of neglecting bending stiffness of thin shells at large t...
-
作者：Chen, Gang; Han, Qingxia; Li, Wan-Xiang; Hai, Rong; Ding, Shou-Wei
-
作者：Yan, Yan; Zhu, Jiaping; Qiu, Qi; Li, Jigang; Cao, Xiaofeng; Deng, Xian
作者单位：Chinese Academy of Sciences; Institute of Genetics & Developmental Biology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; China Agricultural University
摘要：The plant photoreceptor phytochrome B (phyB) mediates the responses of plants to red (R) light. Trimethylation of histone H3 at Lys27 (H3K27me3) plays a crucial role in governing gene expression and controlling the response of plants to environmental changes. However, how dynamic H3K27me3 mediates plant response to R light is poorly understood. Here, we report that RELATIVE OF EARLY FLOWERING 6 (REF6), an H3K27me3 demethylase, promotes hypocotyl elongation under R light in Arabidopsis. Upon ex...
-
作者：Lecker, Maya; Hallock, Scott; Danielson, Axel; Van Aertrickc, Maximilien; Kindt, Merel; Aviezer, Hillel
作者单位：Hebrew University of Jerusalem; University of Amsterdam
摘要：Central emotion theories assume that during threatening and dangerous events the human face signals a prototypical, distinct, and universally recognized expression of fear which can be accurately decoded by conspecific perceivers. Due to the importance of fear expressions, an unusually large body of research has been dedicated to exploring their evolutionary origins, neurobiological mechanisms, and clinical significance. However, these studies typically utilize highly recognizable posed actor ...
-
作者：Wang, Yinhang; Wang, Xingyu; Alabdullatif, Salam; Homma, Sachiko T.; Alekseyev, Yuriy O.; Zhou, Lan
作者单位：Boston University; Boston University; Boston University
摘要：Infiltrating macrophages contribute to muscle dystrophic changes in Duchenne musblood Ly6Chi inflammatory monocyte recruitment. This is accompanied by transient improvement of muscle damage, fibrosis, and regeneration. The benefit, however, is lost after the expansion of intramuscular Ly6Clo macrophages. To address the mechanisms underlying the Ly6Clo macrophage expansion, we compared mdx5cv/Nur77-/- and mdx5cv/ Ccr2-/-/Nur7-/- mice with mdx5cv and mdx5cv/Ccr2-/- mice, respectively, and found ...
