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作者：Wan, Yimei; Hudson, Rhea; Smith, Jordyn; Forman-Kay, Julie D.; Ditlev, Jonathon A.
作者单位：University of Toronto; University of Toronto; Hospital for Sick Children (SickKids); University of Toronto; Hospital for Sick Children (SickKids); Yale University; Stanford University
摘要：The cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride channel whose dysfunction leads to intracellular accumulation of chloride ions, dehydration of cell surfaces, and subsequent damage to airway and ductal organs. Beyond its function as a chloride channel, interactions between CFTR, epithelium sodium channel, and solute carrier (SLC) transporter family membrane proteins and cytoplasmic proteins, including calmodulin and Na+/H+ exchanger regulatory factor- 1 (NHERF- 1), ...
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作者：Moriguchi, Yusuke; Watanabe, Ryoichi; Sakata, Chifumi; Johnston, Ariel Zeleznikow-; Wang, Jue; Saji, Noburo; Tsuchiya, Naotsugu
作者单位：Kyoto University; Japan Society for the Promotion of Science; Monash University; Monash University; Waseda University; National Institute of Information & Communications Technology (NICT) - Japan
摘要：Examination of the subjective qualitative aspects of an experience, or qualia in short, is a fundamental and core aspect of consciousness research. How can we characterize the particular quality of redness, i.e. a red quale? Based on a recent proposal of the structural characterization of qualia, which did not rely on verbal descriptions, we developed a task that obtained pairwise similarity judgments at four graded levels, with easy and intuitive visual interfaces designed to engage young chi...
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作者：Wolfe, Kennedy; Desbiens, Amelia A.; Patel, Frances; Kwong, Sarah; Fisher, Eric; Mumby, Peter J.; Uthicke, Sven
作者单位：University of Queensland; Commonwealth Scientific & Industrial Research Organisation (CSIRO); Australian Institute of Marine Science; James Cook University
摘要：Variability in predator-prey interactions can modulate population dynamics with impacts scalable to entire ecosystems. As notorious corallivores, crown-of-thorns sea stars (CoTS; Acanthaster spp.) have caused extensive losses of coral habitat during unexplained population outbreaks across the Indo-Pacific. While predation of adult CoTS may help to suppress their outbreaks, it does not sufficiently explain their profound boom-bust dynamics and so remains equivocal. Factors influencing early pos...
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作者：Das, Saikat; Reza, Seyednejad Seyed; Copar, Simon; Dhara, Surajit
作者单位：University of Hyderabad; University of Ljubljana
摘要：In emulsions of multicomponent fluids, the dispersed phase forms tiny droplets in the continuous phase. In situ control and manipulation to achieve diversity in emulsion droplets for emerging applications is challenging. In a liquid crystal-based emulsion, the surface anchoring of the molecules at the isotropic fluid-liquid crystal interface introduces elastic distortions that result in anisotropic interparticle interactions, similar to electrostatic interactions between multipoles, which also...
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作者：Pellegrin, Clement; Damm, Anika; Sperling, Alexis L.; Molloy, Beth; Shin, Dio S.; Long, Jonathan; Brett, Paul; Iguh, Tochukwu Chisom; Kranse, Olaf P.; Bravo, Andrea Diaz-Tendero; Lynch, Sarah Jane; Senatori, Beatrice; Vieira, Paulo; Mejias, Joffrey; Kumar, Anil; Masonbrink, Rick E.; Maier, Tom R.; Baum, Thomas J.; van den Akker, Sebastian
作者单位：University of Cambridge; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); John Innes Center; United States Department of Agriculture (USDA); USDA Agricultural Research Service; Iowa State University; Iowa State University
摘要：Pathogens must precisely tailor their gene expression to cause infection. However, a signaling cascade from host signal to effector production has remained elusive for metazoan pathogens. Here, we show that plants contain molecular signals, termed effectostimulins, that activate the first identified regulator of plant-parasitic nematode effectors. SUGR-1 directly binds effector promoters, and is central to a transcriptional network that activates 58 effector genes. Importantly, we demonstrate ...
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作者：Yan, Yu; Liu, Zhiyong; Chen, Lei; Chen, Xiaohong; Lin, Kairong; Zeng, Zhenzhong; Lan, Xin; Huang, Liyan; Wang, Yajun; Yao, Lili; Cheng, Linyin; Ma, Zhimin
作者单位：Sun Yat Sen University; Southern Marine Science & Engineering Guangdong Laboratory; Southern Marine Science & Engineering Guangdong Laboratory (Zhuhai); Sichuan University; Southern University of Science & Technology; Sun Yat Sen University; State University System of Florida; University of Central Florida; University of Arkansas System; University of Arkansas Fayetteville; University of Helsinki
摘要：While vegetation brings positive benefits for climate mitigation and adaptation, the impact of ongoing global greening remains controversial due to its uncertain effects on hydrological cycle. Here, we quantitatively assess the impact of vegetation dynamics on global water availability by proposing a comprehensive framework to quantify the terrestrial water sink and source scores associated with vegetation dynamics. These scores serve as indicators of whether large alterations in water resourc...
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作者：Cao, Mingming; Gan, Yu; Huang, Yingdan; Tong, Jing; Xiong, Chen; Chen, Yajie; Chen, Bing; Huang, Ruixuan; Xie, Bangxiang; Deng, Jun; Huang, Shenglin; He, Xianghuo; Hao, Qian; Zhou, Xiang
作者单位：Fudan University; Fudan University; Fudan University; Fudan University; Nanchang University; Capital Medical University; Fudan University; Fudan University
摘要：The tumor suppressor p53 can trigger tumor resistance to chemotherapy by facilitating DNA damage repair and maintaining genomic integrity. Here, we report that a p53- induced circular RNA circASCC3 promotes chemotherapeutic resistance by resolving R- loops. Our results reveal that p53 directly activates the transcription of is identified to inhibit the formation of circASCC3 by associating with its flanking regions. Importantly, p53 facilitates the formation of circASCC3 by repressing the expr...
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作者：Cooper, Melissa L.; Gildea, Holly K.; Selles, Maria Clara; Katafygiotou, Eleni; Liddelow, Shane A.; Chao, Moses, V
作者单位：New York University; New York University; NYU Langone Medical Center; NYU Langone Medical Center
摘要：Glaucomatous optic neuropathy, or glaucoma, is the world's primary cause of irreversible blindness. Glaucoma is comorbid with other neurodegenerative diseases, but how it might impact the environment of the full central nervous system to increase neurodegenerative vulnerability is unknown. Two neurodegenerative events occur early in the optic nerve, the structural link between the retina and brain: loss of anterograde transport in retinal ganglion cell (RGC) axons and early alterations in astr...
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作者：Guo, Jiahuan; Kneeshaw, Daniel; Peng, Changhui; Wu, Yaoxing; Feng, Lei; Qu, Xinjing; Wang, Weifeng; Pan, Chang; Feng, Huili
作者单位：Hainan University; University of Quebec; University of Quebec Montreal; Hunan Normal University; International Centre for Bamboo & Rattan; Nanjing University; Nanjing Forestry University; Anqing Normal University
摘要：Mixed- species plantations are increasingly recognized for their potential to maintain forest biodiversity and soil health; however, a comprehensive assessment of their global effectiveness is lacking. To fill this knowledge gap, we conducted a meta- analysis of 7,045 paired observations between mixed- species and monoculture plantations, derived from 311 studies across diverse forest ecosystems worldwide. Our results show that mixed- species plantations significantly increased understory plan...
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作者：Jahan, Cyprien; Bonnet-Madin, Lucie; Machida, Shinichi; Sobhian, Bijan; Thenin-Houssier, Suzie; Benkirane, Monsef
作者单位：Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Universite de Montpellier; Japan Institute for Health Security (JIHS); National Center for Global Health & Medicine - Japan
摘要：To ensure optimal replication and spread, viruses have evolved countermeasures to evade type 1 IFN-mediated antiviral activity.During the early viral replication cycle steps until uncoating, the HIV-1 core protects viral pathogen associated molecular patterns (viral RNA and reverse transcription products) from recognition by innate immune sensors, including cGAS. However, after capsid uncoating, unintegrated viral DNA (uvDNA) becomes accessible. Here, we show that HIV-1 uses chromatin-mediated...
