-
作者：Li, Shaowei; Chen, Xi; Xin, Jingxue; Liu, Bowen; Liu, Bo; Hu, Min; Wong, Wing Hung
作者单位：Stanford University; Stanford University; Stanford University
摘要：Stem cells possess inherent properties of self- renewal and differentiation, and thus hold significant promise for regenerating damaged tissues or replacing lost cells. Unless their therapeutic effects are solely mediated by paracrine, transplanted stem cells need to be highly plastic to adapt to the host tissue environment and differentiate into constituent tissue- specific cells for tissue repair. Stem cells used in current cell- based therapies either have limited differentiation potential ...
-
作者：Tempest, Nicola; Soul, Jamie; Hill, Christopher J.; Gutierrez, Eva Caamano; Hapangama, Dharani K.
作者单位：University of Liverpool; University of Liverpool; University of Liverpool
摘要：Recurrent implantation failure (RIF) is a devastating condition that leaves many undergoing fertility treatment childless. The human endometrium is receptive to a blastocyst for a brief period, the window of implantation. Critical knowledge underpinning biological processes leading to RIF, essential for effective treatment, is lacking. We employed spatial transcriptomics to define region- and cell- type- specific differences in endometrial gene expression in luteinizing hormone timed biopsies ...
-
作者：Waight, Hannah; Yuan, Yin; Roberts, Margaret E.; Stewart, Brandon M.
作者单位：University of Oregon; University of California System; University of California San Diego; Princeton University; Princeton University
摘要：Autocratic governments around the world use clandestine propaganda campaigns to influence the media. We document a decade-long trend in China toward the planting of government-authored articles in party and commercial newspapers. To examine this phenomenon, we develop an approach to identifying scripted propaganda-the coerced reprinting of lightly adapted government-authored articles in newspapers- that leverages the footprints left by the government when making media interventions. We show th...
-
作者：Zhang, Zheng; Meng, Yichen; Lin, Tao; Zhang, Zhanrong; Tao, Zhengbo; Yin, Haozan; Yang, Fu; Zhou, Xuhui
-
作者：Menefee, Anne; Wiseman, Hannah; Blumsack, Seth; Helbing, Michael
作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; The Santa Fe Institute
-
作者：Sang, Xiaohong; Jiao, Haizhan; Meng, Qian; Fang, Xiong; Pan, Qi; Zhou, Jiao; Qian, Tingli; Zhang, Wanqin; Xu, Yan; An, Jing; Huang, Ziwei; Hu, Hongli
作者单位：The Chinese University of Hong Kong, Shenzhen; The Chinese University of Hong Kong, Shenzhen; Tsinghua University; University of California System; University of California San Diego
摘要：CXCR4 (CXC chemokine receptor type 4), a member of the G protein-coupled receptor superfamily, plays a role in cell migration and functions as a coreceptor for HIV entry. Molecular therapeutics targeting CXCR4 have been under intensive investigation. To date, only two small-molecule antagonist drugs targeting CXCR4, plerixafor (AMD3100) and mavorixafor (AMD070), have been approved. Here, we present the high-resolution structures of CXCR4 complexed with AMD3100 and AMD070, as well as a small-mo...
-
作者：Chae, Rebecca L.; Siddiqui, Rafay; Xu, Yan
-
作者：Ma, Xixian; Lu, Yan; Stoneking, Mark; Xu, Shuhua
作者单位：Chinese Academy of Sciences; Shanghai Institute of Nutrition & Health, CAS; University of Chinese Academy of Sciences, CAS; Shenzhen Bay Laboratory; Fudan University; Fudan University; Max Planck Society; Universite Lyon 1; VetAgro Sup; Centre National de la Recherche Scientifique (CNRS); Fudan University
摘要：Positive selection at the 2q21.3 enhancer region for lactase gene (LCT) expression in Europeans and Africans has long been attributed to selection for lactase persistence (LP), the capacity of adults to digest lactose in milk, presumably because of the benefits associated with milk consumption. While considered a classic example of gene-culture coevolution, recently doubts have been raised about the link between selection at 2q21.3 and LP. Analysis of additional populations could shed further ...
-
作者：Oggero, Silvia; Voisin, Mathieu - Benoit; Picco, Francesca; Huerta, Miguel A.; Cecconello, Chiara; Burgoyne, Thomas; Perretti, Mauro; Malcangio, Marzia
作者单位：University of London; King's College London; University of London; Queen Mary University London; University of Granada; University of London; University College London; Royal Brompton Hospital
摘要：Pain independent of disease activity is frequently reported by rheumatoid arthritis patients and remains undertreated. Preclinical evidence suggests that imbalance of neuroimmune proresolving interactions within dorsal root ganglia (DRG) rather than at the site of inflammation plays mechanistic roles in persistent arthritis pain. Here, we inhibited production of proresolving lipid mediators by silencing 12/15-lipoxygenase expression in CX3CR1+ monocyte/macrophages conditional knockout (cKO) mi...
-
作者：Yan, Yu; Liu, Zhiyong; Chen, Lei; Chen, Xiaohong; Lin, Kairong; Zeng, Zhenzhong; Lan, Xin; Huang, Liyan; Wang, Yajun; Yao, Lili; Cheng, Linyin; Ma, Zhimin
作者单位：Sun Yat Sen University; Southern Marine Science & Engineering Guangdong Laboratory; Southern Marine Science & Engineering Guangdong Laboratory (Zhuhai); Sichuan University; Southern University of Science & Technology; Sun Yat Sen University; State University System of Florida; University of Central Florida; University of Arkansas System; University of Arkansas Fayetteville; University of Helsinki
摘要：While vegetation brings positive benefits for climate mitigation and adaptation, the impact of ongoing global greening remains controversial due to its uncertain effects on hydrological cycle. Here, we quantitatively assess the impact of vegetation dynamics on global water availability by proposing a comprehensive framework to quantify the terrestrial water sink and source scores associated with vegetation dynamics. These scores serve as indicators of whether large alterations in water resourc...
