11期

最新文章

• Amplification- free, OR- gated CRISPR- Cascade reaction for pathogen detection in blood samples AI翻译
  作者：Lim, Jongwon; Van, An Bao; Koprowski, Katherine; Wester, Matthew; Valera, Enrique; Bashir, Rashid
  作者单位：University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; Chan Zuckerberg Initiative (CZI)
  摘要：Rapid and accurate detection of DNA from disease- causing pathogens is essential for controlling the spread of infections and administering timely treatments. While traditional molecular diagnostics techniques like PCR are highly sensitive, they include nucleic acid amplification and many need to be performed in centralized laboratories, limiting their utility in point- of- care settings. Recent advances in CRISPR- based diagnostics (CRISPR- Dx) have demonstrated the potential for highly speci...
• A family of bacterial actin homologs forms a three-stranded tubular structure AI翻译
  作者：Bergeron, Julien R. C.; Lale-Farjat, Shamar L. M.; Lewicka, Hanna M.; Parry, Chloe; Kollman, Justin M.
  作者单位：University of London; King's College London; University of Washington; University of Washington Seattle; Imperial College London
  摘要：The cytoskeleton is crucial for cell organization and movement. In Eukaryotes, it largely consists of the protein actin, that forms a double-stranded linear filamentous structure in the presence of ATP and disassemble upon ATP hydrolysis. Bacteria also possess actin homologs, that drive fundamental cellular processes, including cell division, shape maintenance, and DNA segregation. Like eukaryotic actin, bacterial actins assemble into dynamic polymers upon ATP binding, however variation in int...
• Reply to Crabtree: Market research panels augmenting microtask platforms AI翻译
  作者：Gvirtz, Andres; Sabherwal, Anandita
  作者单位：University of London; King's College London; Princeton University; Boston College
• A unified neural representation model for spatial and conceptual computations AI翻译
  作者：Haga, Tatsuya; Oseki, Yohei; Fukai, Tomoki
  作者单位：Okinawa Institute of Science & Technology Graduate University; National Institute of Information & Communications Technology (NICT) - Japan; University of Tokyo
  摘要：The hippocampus and entorhinal cortex encode spaces by spatially local and hexagonal grid activity patterns (place cells and grid cells), respectively. In addition, the same brain regions also implicate neural representations for nonspatial, semantic concepts (concept cells). These observations suggest that neurocomputational mechanisms for spatial knowledge and semantic concepts are related in the brain. However, the exact relationship remains to be understood. Here, we show a mathematical co...
• Spinal TRPC3 promotes neuropathic pain and coordinates phospholipase C-induced mechanical hypersensitivity AI翻译
  作者：Tobori, Shota; Tamada, Kosei; Uemura, Nagi; Sawada, Kyoko; Kakae, Masashi; Nagayasu, Kazuki; Nakagawa, Takayuki; Mori, Yasuo; Kaneko, Shuji; Shirakawa, Hisashi
  作者单位：Kyoto University; Wakayama Medical University; University of Osaka; Kyoto University
  摘要：Neuropathic pain is a debilitating chronic condition mainly caused by peripheral nerve injury. However, the cellular and molecular mechanisms underlying this condition remain unclear. Transient receptor potential canonical 3 (TRPC3), a TRP channel that is activated by downstream of the Gq-phospholipase C (PLC) axis, is expressed in the somatosensory system. Therefore, the present study investigated its pathophysiological role in neuropathic pain following peripheral nerve injury. Here, partial...
• Enhancement of mitochondrial calcium uptake is cardioprotective against maladaptive hypertrophy by retrograde signaling uptuning Akt AI翻译
  作者：Zaglia, Tania; Campo, Antonio; Moro, Nicola; Di Mauro, Vittoria; Borile, Giulia; Menabo, Roberta; Antonucci, Salvatore; Poli, Laura; Campesan, Marika; Carullo, Pierluigi; Martinazzi, Sara; Luciani, Giovanni B.; Hammer, Karin; Pesce, Paola; Bariani, Riccardo; Faggian, Giuseppe; Maier, Lars; Ventura, Laura; De Stefani, Diego; Mammucari, Cristina; Rizzuto, Rosario; Catalucci, Daniele; Di Lisa, Fabio; Mongillo, Marco
  作者单位：University of Padua; Veneto Institute Molecular Medicine; Consiglio Nazionale delle Ricerche (CNR); Istituto di Ricerca Genetica e Biomedica (IRGB-CNR); University of Verona; University of Regensburg; University of Padua; University of Padua; University of Padua; Consiglio Nazionale delle Ricerche (CNR)
  摘要：Regulation of mitochondrial Ca2+ uptake is critical in cardiac adaptation to chronic stressors. Abnormalities in Ca2+ handling, including mitochondrial uptake mechanisms, have been implicated in pathological heart hypertrophy. Enhancing mitochondrial Ca2+uniporter (MCU) expression has been suggested to interfere with maladaptive development of heart failure. Here, we addressed whether MCU modulation affects the cardiac response to pressure overload. MCU content was quantified in human and muri...
• A solvable model for strongly interacting nonequilibrium excitons AI翻译
  作者：Song, Zhenhao; Cookmeyer, Tessa; Balents, Leon
  作者单位：University of California System; University of California Santa Barbara; University of California System; University of California Santa Barbara; Canadian Institute for Advanced Research (CIFAR)
  摘要：We study the driven-dissipative Bose-Hubbard model with an all-to-all hopping term in the system Hamiltonian, while subject to incoherent pumping and decay from the environment. This system is naturally probed in several recent experiments on excitons in WS2/WSe2 moir & eacute; systems, as well as quantum simulators. By positing a particular form of coupling to the environment, we derive the Lindblad jump operators and show that, in certain limits, the system admits a closed-form expression fo...
• Identifying the interactions conferring functional mechanical rigidity on RNase-resistant RNA from Zika virus AI翻译
  作者：Zhaguparov, Daniiar; Zhao, Meng; Sekar, Rohith Vedhthaanth; Woodside, Michael T.
  作者单位：University of Alberta; University of Alberta; University of Alberta; Chinese Academy of Sciences; Hangzhou Institute of Medicine, CAS
  摘要：Some viruses counter host-cell efforts to digest invading viral RNA by using special structures resistant to host RNases, known as exoribonuclease-resistant RNAs (xrRNAs). xrRNAs typically form an unusual fold with the 5 '-end threaded through a ring consisting of a multihelix junction closed by a pseudoknot. By using single-molecule force spectroscopy (SMFS), we previously showed that a Zika virus xrRNA is extremely rigid mechanically, withstanding very high forces, and that this mechanical r...
• The genetic regulatory architecture and epigenomic basis for age-related changes in rattlesnake venom (vol 121,e2313440121,2024) AI翻译
  作者：Hogan, Michael P.; Holding, Matthew L.; Nystrom, Gunnar S.; Colston, Timothy J.; Bartlett, Daniel A.; Mason, Andrew J.; Ellsworth, Schyler A.; Rautsaw, Rhett M.; Lawrence, Kylie C.; Strickland, Jason L.; He, Bing; Fraser, Peter; Margres, Mark J.; Gilbert, David M.; Gibbs, H. Lisle; Parkinson, Christopher L.; Rokyta, Darin R.
• The impact of political assassinations on turnout: Evidence from Colombia AI翻译
  作者：Arjona, Ana; Chacon, Mario; Garcia-Montoya, Laura
  作者单位：Northwestern University; Universidad EAFIT; University of Toronto
  摘要：Although a growing literature has investigated the effects of various types of civil war violence on political behavior, no study has examined the impact of assassinations targeting politicians. This is a critical omission, as violence against local politicians is prevalent across civil war contexts and may be the most consequential form of violence for political participation by affecting both candidate supply and voter demand. Using an original dataset of nearly 2,000 killings of Colombian l...