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最新文章

• SOS1 inhibitor BI-3406 shows in vivo antitumor activity akin to genetic ablation and synergizes with a KRASG12D inhibitor in KRAS LUAD AI翻译
  作者：Baltanas, Fernando C.; Kramer-Drauberg, Maximilian; Garcia-Navas, Rosula; Patrucco, Enrico; Petrini, Ettore; Arnhof, Heribert; Olarte-SanJuan, Andrea; Rodriguez-Ramos, Pablo; Borrajo, Javier; Calzada, Nuria; Castellano, Esther; Mair, Barbara; Kostyrko, Kaja; Hofmann, Marco H.; Ambrogio, Chiara; Santos, Eugenio
  作者单位：Consejo Superior de Investigaciones Cientificas (CSIC); Virgen del Rocio University Hospital; Consejo Superior de Investigaciones Cientificas (CSIC); University of Sevilla; CSIC-JA-USE - Instituto de Biomedicina de Sevilla (IBIS); University of Sevilla; University of Turin; Boehringer Ingelheim; University of Salamanca; University of Salamanca; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC-USAL - Instituto de Biologia Molecular y Celular del Cancer de Salamanca (IBMCC)
  摘要：We evaluated the in vivo therapeutic efficacy and tolerability of BI-3406-mediated pharmacological inhibition of SOS1 in comparison to genetic ablation of this universal Ras-GEF in various KRAS-dependent experimental tumor settings. Contrary to the rapid lethality caused by SOS1 genetic ablation in SOS2KO mice, SOS1 pharmacological inhibition by its specific inhibitor BI-3406 did not significantly affect animal weight/viability nor cause noteworthy systemic toxicity. Allograft assays using dif...
• Genetic or therapeutic disruption of the Reelin/Apoer2 signaling pathway improves inflammatory arthritis outcomes AI翻译
  作者：Calvier, Laurent; Wasser, Catherine R.; Solow, E. Blair; Wu, Sharon; Evers, Bret M.; Karp, David S.; Kounnas, Maria Z.; Herz, Joachim
  作者单位：University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center
  摘要：Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial inflammation, pannus formation, and progressive joint destruction. The inflammatory milieu in RA drives endothelial cell activation and upregulation of adhesion molecules, thus facilitating leukocyte infiltration into the synovium. Reelin, a circulating glycoprotein previously implicated in endothelial activation and leukocyte recruitment in diseases such as atherosclerosis and multiple sclerosis, has emerged a...
• Learning reshapes the hippocampal representation hierarchy AI翻译
  作者：Chiossi, Heloisa S. C.; Nardin, Michele; Tkacik, Gasper; Csicsvari, Jozsef
  作者单位：Institute of Science & Technology - Austria; Howard Hughes Medical Institute
  摘要：A key feature of biological and artificial neural networks is the progressive refinement of their neural representations with experience. In neuroscience, this fact has inspired several recent studies in sensory and motor systems. However, less is known about how higher associational cortical areas, such as the hippocampus, modify representations throughout the learning of complex tasks. Here, we focus on associative learning, a process that requires forming a connection between the representa...
• Targeting amyloid-β in glaucoma treatment (vol 104, pg 13444, 2007) AI翻译
  作者：Guo, Li; Salt, Thomas E.; Luong, Vy; Wood, Nicholas; Cheung, William; Maass, Annelie; Ferrari, Giulio; Russo-Marie, Francoise; Sillito, Adam M.; Cheetham, Michael E.; Moss, Stephen E.; Fitzke, Frederick W.; Cordeiro, M. Francesca
• How spatiotemporal dynamics can enhance ecosystem resilience AI翻译
  作者：Moreno-Spiegelberg, Pablo; Rietkerk, Max; Gomila, Damia
  作者单位：Consejo Superior de Investigaciones Cientificas (CSIC); Universitat de les Illes Balears; CSIC-UIB - Instituto de Fisica Interdisciplinar y Sistemas Complejos (IFISC); Utrecht University
  摘要：We study how self-organization in systems showing complex spatiotemporal dynamics can increase ecosystem resilience. We consider a general simple model that includes positive feedback as well as negative feedback mediated by an inhibitor. We apply this model to Posidonia oceanica meadows, where positive and negative feedbacks are well documented, and there is empirical evidence of the role of sulfide accumulation, toxic for the plant, in driving complex spatiotemporal dynamics. We describe a p...
• Initiation of transthyretin aggregation at neutral pH by fluid agitation AI翻译
  作者：Ritsch, Irina; Dyson, H. Jane; Wright, Peter E.
  作者单位：Scripps Research Institute; Scripps Research Institute
  摘要：The transthyretin (TTR) tetramer, assembled as a dimer of dimers, transports thyroxine and retinol binding protein in blood plasma and cerebrospinal fluid. Aggregation of wild type (WT) or pathogenic variant TTR leads to transthyretin amyloidosis, which is associated with neurodegenerative and cardiac disease. The trigger for TTR aggregation under physiological conditions is unknown. The tetramer is extremely stable at neutral pH, but aggregation via tetramer dissociation and monomer misfoldin...
• Competition for shared resources increases dependence on initial population size during coalescence of gut microbial communities AI翻译
  作者：Goldman, Doran A.; Xue, Katherine S.; Parrott, Autumn B.; Lopez, Jamie A.; Vila, Jean C. C.; Jeeda, Rashi R.; Franzese, Lauryn R.; Porter, Rachel L.; Gray, Ira J.; DeFelice, Brian C.; Petrov, Dmitri A.; Good, Benjamin H.; Relman, David A.; Huang, Kerwyn Casey
  作者单位：Stanford University; Stanford University; Stanford University; Stanford University; California Institute of Technology; Stanford University; Chan Zuckerberg Initiative (CZI); Stanford University; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA Palo Alto Health Care System
  摘要：The long-term success of introduced populations depends on both their initial size and ability to compete against existing residents, but it remains unclear how these factors collectively shape colonization dynamics. Here, we investigate how initial population (propagule) size shapes the outcome of community coalescence by systematically mixing eight pairs of in vitro microbial communities at ratios that vary over six orders of magnitude, and we compare our results to neutral ecological theory...
• RGMb drives macrophage infiltration to aggravate kidney disease AI翻译
  作者：Kong, Yonglun; Yue, Ming; Xu, Chunhua; Zhang, Jing; Hong, Huiling; Lu, Jiahuan; Wang, Yang; Zhang, Xiaoyi; Chen, Qiuju; Yang, Chen; Liu, Hua - Feng; Qin, Jinzhong; Zhou, Jingying; Lee, Nam Y.; Lin, Bin; Tian, Xiaoyu; Freeman, Gordon J.; Xia, Yin
  作者单位：Chinese University of Hong Kong; CUHK Shenzhen Research Institute; The Chinese University of Hong Kong, Shenzhen; University of Hong Kong; University of Hong Kong; Longgang District Central Hospital of Shenzhen; Hong Kong Polytechnic University; Guangdong Medical University; Nanjing University; University of Arizona; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Chinese University of Hong Kong
  摘要：The importance of macrophages in kidney diseases has been well established; however, the mechanisms underlying the infiltration of macrophages into injured kidneys are not well understood. RGMb is a member of the repulsive guidance molecule (RGM) family. RGMb can be expressed on the cell surface but a large portion of RGMb is localized intracellularly. Among various immune cell types, macrophages express the highest levels of RGMb, but the biological functions of RGMb in macrophages remain lar...
• Efficient mapping of the thalamocortical monosynaptic connectivity in vivo by tangential insertions of high-density electrodes in the cortex (vol 121, e2313048121, 2024) AI翻译
  作者：[Anonymous]
• Infant EEG microstate dynamics relate to fine- grained patterns of infant attention during naturalistic play with caregivers AI翻译
  作者：Bagdasarov, Armen; Markert, Sarah; Gaffrey, Michael S.
  作者单位：Duke University; Children's Hospital of Wisconsin; Medical College of Wisconsin
  摘要：As infants grow, they develop greater attentional control during interactions with others, shifting from patterns of attention primarily driven by caregivers (exogenous) to those that are also self- directed (endogenous). The ability to endogenously control attention during infancy is thought to reflect ongoing brain development and is influenced by patterns of joint attention between infant and caregiver. However, whether measures of infant attentional control and caregiver behavior during in...