The SUbventral- Gland Regulator (SUGR-1) of nematode virulence

• 成果类型: Article
• 署名作者: Pellegrin, Clement; Damm, Anika; Sperling, Alexis L.; Molloy, Beth; Shin, Dio S.; Long, Jonathan; Brett, Paul; Iguh, Tochukwu Chisom; Kranse, Olaf P.; Bravo, Andrea Diaz-Tendero; Lynch, Sarah Jane; Senatori, Beatrice; Vieira, Paulo; Mejias, Joffrey; Kumar, Anil; Masonbrink, Rick E.; Maier, Tom R.; Baum, Thomas J.; van den Akker, Sebastian
• 署名单位: University of Cambridge; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); John Innes Center; United States Department of Agriculture (USDA); USDA Agricultural Research Service; Iowa State University; Iowa State University
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-11283
• DOI: 10.1073/pnas.2415861122
• 发表日期: 2025-03-18
• 关键词: double-stranded-rna; molecular characterization; functional-analysis; transcriptional regulator; effector; genes; expression; pathogenicity; modulation; helminths

摘要

Pathogens must precisely tailor their gene expression to cause infection. However, a signaling cascade from host signal to effector production has remained elusive for metazoan pathogens. Here, we show that plants contain molecular signals, termed effectostimulins, that activate the first identified regulator of plant-parasitic nematode effectors. SUGR-1 directly binds effector promoters, and is central to a transcriptional network that activates 58 effector genes. Importantly, we demonstrate that downregulation of sugr-1 inhibits parasitism, underlining SUGR-1 signaling as a valuable target for crop protection and food security. This, in the wider context of nematodes as parasites of humans and other animals, has scope for potentially broader impact: Disrupting effector production could, in principle, be applied to any pathogen that secrets effectors.