Dopaminergic neurons in the paraventricular hypothalamus extend the food consumption phase

• 成果类型: Article
• 署名作者: Ariyani, Winda; Yoshikawa, Chiharu; Tsuneoka, Haruka; Amano, Izuki; Imayoshi, Itaru; Ichinose, Hiroshi; Sumi-Ichinose, Chiho; Koibuchi, Noriyuki; Kitamura, Tadahiro; Kohno, Daisuke
• 署名单位: Gunma University; Gunma University; Kyoto University; Kyoto University; Kyoto University; Fujita Health University
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-11498
• DOI: 10.1073/pnas.2411069122
• 发表日期: 2025-03-28
• 关键词: lateral habenula; sim1 neurons; pomc neurons; circuits; obesity; stem

摘要

Feeding behavior is controlled by various neural networks in the brain that are involved in different feeding phases: Food procurement, consumption, and termination. However, the specific neural circuits controlling the food consumption phase remain poorly understood. Here, we investigated the roles of dopaminergic neurons in the paraventricular nucleus of the hypothalamus (PVH) in the feeding behavior in mice. Our results indicated that the PVH dopaminergic neurons were critical for extending the food consumption phase and involved in the development of obesity through epigenetic mechanisms. These neurons synchronized with proopiomelanocortin neurons during consumption, were stimulated by proopiomelanocortin activation, and projected to the lateral habenula (LHb), where dopamine receptor D2 was involved in the increase in food consumption. In addition, upregulated tyrosine hydroxylase (TH) expression in PVH was associated with obesity and indispensable for obesity induction in mice lacking Dnmt3a. Taken together, our results highlight the roles of PVH dopaminergic neurons in promoting food consumption and obesity induction.