16期

最新文章

• A rare variant in GPR156 associated with depression in a Mennonite pedigree causes habenula hyperactivity and stress sensitivity in mice AI翻译
  作者：Millera, Bradley R.; Gonzaga-Jaureguic, Claudia; Brigattie, Karlla W.; de Jonga, Job; Breeseg, Robert S.; Ko, Seungyeon; Puffenbergere, Erik G.; Van Houtc, Cristopher; Younge, Millie; Lunah, Victor M.; Staplesc, Jeffrey; First, Michael B.; Gregoirea, Hilledna J.; Dworka, Andrew J.; Pefanisg, Evangelos; Mccarthyc, Shane; Brydges, Susannah; Rojasg, Jose; Yec, Bin; Stahlc, Eli; Di Gioiac, Silvio Alessandro; Hena, Rene; Elwoodi, Kevin; Rosoklijaa, Gorazd; Lic, Dadong; Mellisg, Scott; Careyi, David; Crollg, Susan D.; Overtonc, John D.; Macdonaldg, Lynn E.; Economidesc, Aris N.; Shuldinerc, Alan R.; Chuhmaf, Nao; Rayportf, Stephen; Aminj, Najaf; Kushnera, Steven A.; Haberg, Nicole Alessandri-; Markx, Sander; Strauss, Kevin A.
  作者单位：Columbia University; New York State Psychiatry Institute; Regeneron; Universidad Nacional Autonoma de Mexico; New York State Psychiatry Institute; Pennsylvania Commonwealth System of Higher Education (PCSHE); Temple University; Geisinger Health System; Erasmus University Rotterdam; Erasmus MC; Erasmus University Rotterdam; Erasmus MC; University of Massachusetts System; University of Massachusetts Worcester; University of Massachusetts System; University of Massachusetts Worcester
  摘要：Major depressive disorder (MDD) is a leading cause of disability worldwide. Risk for MDD is heritable, and the genetic structure of founder populations enables investigation of rare susceptibility alleles with large effect. In an extended Old Order Mennonite family cohort, we identified a rare missense variant in GPR156 (c.1599G>T, p.Glu533Asp) associated with a two-fold increase in the relative risk of MDD. GPR156 is an orphan G protein-coupled receptor localized in the medial habenula, a reg...
• Dynamic coexistence driven by physiological transitions in microbial communities AI翻译
  作者：Narla, Avaneesh V.; Hwa, Terence; Murugan, Arvind
  作者单位：University of California System; University of California San Diego; University of Chicago
  摘要：Microbial ecosystems are commonly modeled by fixed interactions between species in steady exponential growth states. However, microbes in exponential growth often modify their environments so strongly that they are forced out of the growth state into stressed, nongrowing states. Such dynamics are typical of ecological succession in nature and serial-dilution cycles in the laboratory. Here, we introduce a phenomenological model, the Community State Model, to gain insight into the dynamic coexis...
• CD70 recruitment to the immunological synapse is dependent on CD20 in B cells AI翻译
  作者：Arp, Abbey B.; Gutierrez, Andrea Abel; ter Beest, Martin; Franken, Guus A.; Warner, Harry; Furones, Andrea Rodgers; Kenyon, Angelique N.; Jaeger, Franziska; Cabrera-Orefice, Alfredo; Klaesener, Kathrin; van Deventer, Sjoerd; Droesen, Lenny; Dunlock, Vera Marie E.; Classens, Rene; Staniek, Julian; Borst, Jannie; Reth, Michael; Brandt, Ulrich; Gros, Piet; Kuijpersi, Taco W.; Heemskerk, Mirjam H. M.; Rizzi, Marta; Cano, Laia Querol; van Spriel, Annemiek B.
  作者单位：Radboud University Nijmegen; Utrecht University; Radboud University Nijmegen; University of Freiburg; University of Freiburg; University of Freiburg; University of Freiburg; Leiden University; Leiden University Medical Center (LUMC); Leiden University; Leiden University Medical Center (LUMC); Emma Children's Hospital; University of Amsterdam; Leiden University; Leiden University Medical Center (LUMC); Medical University of Vienna; University of Freiburg; Johns Hopkins University; Johns Hopkins Medicine
  摘要：CD20 is a four-transmembrane protein expressed at the surface of B cells from late pro-B cells to memory B cells, with the exception of plasma cells. Its expression pattern makes it an attractive therapeutic target for different B cell malignancies and autoimmune diseases. Despite the clinical success of CD20-targeting antibodies, the biology of the CD20 protein is still not well understood. We investigated CD20 binding partners in the membrane of human B cells using immunoprecipitation follow...
• Structural basis of excitatory amino acid transporter 3 substrate recognition AI翻译
  作者：Qiu, Biao; Boudker, Olga
  作者单位：Cornell University; Weill Cornell Medicine; Howard Hughes Medical Institute; Cornell University; Weill Cornell Medicine
  摘要：Excitatory amino acid transporters (EAATs) reside on cell surfaces and uptake substrates, including L-glutamate, L-aspartate, and D-aspartate, using ion gradients. Among five EAATs, EAAT3 is the only isoform that can efficiently transport L-cysteine, a substrate for glutathione synthesis. Recent studies suggest that EAAT3 also transports the oncometabolite R-2-hydroxyglutarate (R-2HG). Here, we examined the structural basis of substrate recognition by determining the cryogenic electron microsc...
• Assessing neighborhoods, wealth differentials, and perceived inequality in preindustrial societies AI翻译
  作者：Thompson, Amy E.; Munson, Jessica; Ortman, Scott G.; Ramon, Andres G. Mejia; Feinman, Gary M.; Quequezana, Gabriela Cervantes; Cruz, Pablo; Green, Adam S.; Lawrence, Dan; Roscoe, Paul
  作者单位：University of Texas System; University of Texas Austin; University of Colorado System; University of Colorado Boulder; The Santa Fe Institute; Okinawa Institute of Science & Technology Graduate University; Autonomous University of Barcelona; Field Museum of Natural History (Chicago); Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); University of York - UK; University of York - UK; Durham University; University of Maine System; University of Maine Orono; University of Maine System; University of Maine Orono
  摘要：Humans often live in neighborhoods, nested socio-spatial clusters within settlements of varying size and population density. In today's cities, neighborhoods are often characterized as relatively homogenous and may exhibit segregation along various socioeconomic dimensions. However, even within neighborhoods of similar social or economic status, there is often residential disparity, which in turn impacts perceived inequality. Drawing on the Global Dynamics of Inequality (GINI) project database...
• Sex chromosome evolution in haploid plants: Microchromosomes, disappearing chromosomes, and giant chromosomes AI翻译
  作者：Charlesworth, Deborah
  作者单位：University of Edinburgh
  摘要：As in many diploid organisms with genetic sex determination, haploid-dominant organisms have also evolved sex chromosomes or extensive genomic regions that lack genetic recombination. An understanding of sex chromosome evolution should explain the causes and consequences of such regions in both diploids and haploids. However, haploids have been little studied, even though differences from sex chromosomes in diploids carry implications concerning the evolution of suppressed recombination in dip...
• Development of DPP-4-resistant CXCL9-Fc and CXCL10-Fc chemokines for effective cancer immunotherapy AI翻译
  作者：Lugassy, Jennie; Saleh, Noor Abdala -; Jarrous, Ghada; Turky, Abeer; Saidemberg, Daniel; Bahar, Gabriela Ridner -; Berger, Nir; On, Dana Bar -; Taura, Tetsuya; Wilson, David; Karin, Nathan; Steinman, Lawrence
  作者单位：Technion Israel Institute of Technology; Rappaport Faculty of Medicine; Teva Pharmaceutical Industries; Teva Pharmaceutical Industries; Teva Pharmaceutical Industries USA
  摘要：CXCR3 is a chemokine receptor for three ligands: CXCL9, CXCL10, and CXCL11. Accumulating evidence, including data presented here, suggests that the interaction between CXCL9/CXCL10 and CXCR3 not only attracts CXCR3+ T cells but also cell killing. One of the homeostatic mechanisms that may limit this cycle is the cleavage of the two N- terminal amino acids of these chemokines by Dipeptidyl Peptidase IV (DPP- 4). The modified chemokines retain their ability to bind CXCR3 but no longer activate i...
• In the flow, how fluid dynamics shapes amyloid formation AI翻译
  作者：Willis, Leon F.; Brockwell, David J.; Radford, Sheena E.
  作者单位：University of Leeds
• The world through infant eyes: Evidence for the early emergence of the cardinal orientation bias AI翻译
  作者：Petroff, Zachary J.; Jayaraman, Swapnaa; Smith, Linda B.; Candy, T. Rowan; Bonnen, Kathryn
  作者单位：Indiana University System; Indiana University Bloomington; Indiana University System; Indiana University Bloomington; Indiana University System; Indiana University Bloomington
  摘要：The structure of the environment includes more horizontal and vertical (i.e. cardinal) orientations than oblique orientations, meaning that edges tend to be aligned with or perpendicular to the direction of gravity. This bias in the visual scene is associated with a bias in visual sensitivity in adults. Although infants must learn to function in this biased environment, their immature motor control prevents them from consistently orienting themselves, relative to gravity. This study therefore ...
• A 5-HT- mediated urethral defense against urinary tract infections AI翻译
  作者：Ambrogi, Marcela; Hernandez, Laura L.; Strand, Douglas W.; Kumar, Sathish; Romero, Michael F.; Barasch, Jonathan; Ridlon, Monica; Stietz, Kimberly P. Keil; Vezina, Chad M.
  作者单位：University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; University of Texas System; University of Texas Southwestern Medical Center; Mayo Clinic; Columbia University
  摘要：The urethra is considered a passive conduit for urine. Here, we reveal a surprising multicellular signaling pathway guiding the urethra's dynamic response to an invading pathogen. Using a genetic approach in female mice, we deposited uropathogenic Escherichia coli into the distal urethra to establish a model of ascending urinary tract infection that progresses to the bladder within 4 h. We show that urethral neuroendocrine cells (UNECs), and the serotonin they synthesize, protect the bladder f...