20期

最新文章

• Exact and efficient phylodynamic simulation from arbitrarily large populations AI翻译
  作者：Celentano, Michael; Dewitt, William S.; Prillo, Sebastian; Song, Yun S.
  作者单位：University of Washington; University of Washington Seattle; University of California System; University of California Berkeley; University of California System; University of California Berkeley
  摘要：Many biological studies involve inferring the evolutionary history of a sample of individuals from a large population and interpreting the reconstructed tree. Such an ascertained tree typically represents only a small part of a comprehensive population tree and is distorted by survivorship and sampling biases. Inferring evolutionary parameters from ascertained trees requires modeling both the underlying population dynamics and the ascertainment process. A crucial component of this phylodynamic...
• Dmrt2 and Hmx2 direct intercalated cell diversity in the mammalian kidney through antagonistic and supporting regulatory processes AI翻译
  作者：Parvez, Riana K.; Kim, Doh Kyung; Csipan, Reka L.; Guo, Jinjin; Zeng, Zipeng; Zhang, Chennan C.; Li, Zhongwei; McMahon, Andrew P.
  作者单位：University of Southern California; University of Southern California; California Institute of Technology
  摘要：Intercalated cells (ICs) in the mammalian kidney regulate circulatory pH through IC subtype-restricted actions of bicarbonate transporters: pH is elevated by Slc4a1 restricted to type A-ICs (A-ICs) and depressed by Slc26a4 in type B-IC (B-ICs). NonA-nonB-ICs (nA/nB-ICs) also produce Slc26a4 though their function is unclear. Though both nephron and ureteric progenitor lineages generate A-ICs, the former also generates nA/nB-ICs and the latter B-ICs. Lineage and cell type restricted transporter ...
• Polaronic correlations from optimized ancilla wave functions for the Fermi-Hubbard model AI翻译
  作者：Mueller, Tobias; Thomale, Ronny; Sachdev, Subir; Iqbal, Yasir
  作者单位：University of Wurzburg; University of Zurich; Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Madras; Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Madras; Harvard University
  摘要：We employ a family of ancilla qubit variational wave functions [Y.-H. Zhang and Sachdev, Phys. Rev. Res. 2, 023172 (2020)] to describe the polaronic correlations the pseudogap metal phase of a hole-doped 2D Fermi-Hubbard model. Comparison to ultracold atom quantum simulator data [J. Koepsell etal., Science 374, 82 (2021)] reveals both qualitative and quantitative agreement with the numerical analysis from half-filling up to 80% hole-doping, capturing the crossover from the polaronic regime to ...
• Acoustic percolation switches enable targeted drug delivery controlled by diagnostic ultrasound AI翻译
  作者：Abundo, Maria Paulene; Tifrea, Anna T.; Buss, Marjorie T.; Larrea, Pierina Barturen -; Jin, Zhiyang; Malounda, Dina; Shapiro, Mikhail G.
  作者单位：California Institute of Technology; California Institute of Technology; Howard Hughes Medical Institute
  摘要：Delivering biomedicines to specific sites of disease using remote-controlled devices is a long-standing vision in biomedical research. However, most existing externally triggered delivery systems are based on complex micromachines that are controlled with electromagnetic waves and require custom external instrumentation. Here, we present a drug delivery platform based on a simple protein-containing hydrogel that can be both imaged and triggered to release drugs at specific locations using wide...
• Reevaluating the relationship between female sociality and infant survival in wild baboons AI翻译
  作者：Creighton, Maria J. A.; Lerch, Brian A.; Lange, Elizabeth C.; Silk, Joan B.; Tung, Jenny; Archie, Elizabeth A.; Alberts, Susan C.
  作者单位：Duke University; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; Arizona State University; Arizona State University-Tempe; Arizona State University; Arizona State University-Tempe; Duke University; Duke University; Max Planck Society; Canadian Institute for Advanced Research (CIFAR); University of Notre Dame
  摘要：Over the past few decades, studies have provided strong evidence that the robust links between the social environment, health, and survival found in humans also extend to nonhuman social animals. A number of these studies emphasize the early life origins of these effects. For example, in several social mammals, more socially engaged mothers have infants with higher rates of survival compared to less socially engaged mothers, suggesting that positive maternal social relationships causally impro...
• Time-lagged recurrence: A data-driven method to estimate the predictability of dynamical systems AI翻译
  作者：Dong, Chenyu; Faranda, Davide; Gualandi, Adriano; Lucarini, Valerio; Mengaldo, Gianmarco
  作者单位：National University of Singapore; Centre National de la Recherche Scientifique (CNRS); Universite Paris Saclay; Universite Paris Saclay; Universite PSL; Ecole Normale Superieure (ENS); Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; Institut Polytechnique de Paris; Ecole Polytechnique; University of Cambridge; Istituto Nazionale Geofisica e Vulcanologia (INGV); University of Leicester; National University of Singapore
  摘要：Nonlinear dynamical systems are ubiquitous in nature and they are hard to forecast. Not only they may be sensitive to small perturbations in their initial conditions, but they are often composed of processes acting at multiple scales. Classical approaches based on the Lyapunov spectrum rely on the knowledge of the dynamic forward operator, or of a data-derived approximation of it. This operator is typically unknown, or the data are too noisy to derive its faithful representation. Here, we prop...
• Phase separation of the oncogenic fusion protein EWS::FLI1 is modulated by its DNA-binding domain AI翻译
  作者：Selig, Emily E.; Sohn, Erich J.; Stoja, Aiola; Moreno-Romero, Alma K.; Akula, Shivani; Xu, Xiaoping; Bishop, Alexander J. R.; Libich, David S.
  作者单位：University of Texas System; University of Texas at San Antonio; University of Texas System; University of Texas at San Antonio; University of Texas System; University of Texas at San Antonio
  摘要：Ewing sarcoma (EwS) is an aggressive cancer of bone and soft tissue that predominantly affects children and young adults. A chromosomal translocation joins the low-complexity domain (LCD) of the RNA-binding protein EWS (EWSLCD) with the DNA-binding domain of Friend leukemia integration 1 (FLI1(DBD)), creating EWS::FLI1, a potent fusion oncoprotein essential for EwS development and responsible for over 85% of EwS tumors. EWS::FLI1 forms biomolecular condensates in vivo and promotes tumorigenesi...
• Discovery of an LSD1 PROTAC degrader AI翻译
  作者：Hosseini, Amir; Qiu, Xing; Xiong, Yan; Chiang, Ki Him Nicholas; Catlett, Jerrel; Kaltheuner, Ines; Deng, Zhijie; Ghosh, Sudipta; Shi, Yang; Jin, Jian
  作者单位：Ludwig Institute for Cancer Research; University of Oxford; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai
  摘要：Aberrant expression of lysine-specific demethylase 1 (LSD1) has been implicated in various cancers, including acute myeloid leukemia (AML). Recent studies have revealed both catalytic and noncatalytic oncogenic functions of LSD1, which cannot be effectively addressed by traditional small-molecule inhibitors. Therefore, to remove LSD1 and mitigate its oncogenic activity, we utilized the proteolysis-targeting chimera (PROTAC) approach and developed an LSD1 PROTAC degrader MS9117, which recruits ...
• Brillouin super- cooling/heating in a non- Hermitian phononic dimer AI翻译
  作者：Zhu, Yicheng; Xue, Boyi; Sun, Yuncong; Geng, Qi; Chen, Yuping; Chen, Xianfeng; Jiang, Xiaoshun; Ge, Li; Wan, Wenjie
  作者单位：Shanghai Jiao Tong University; Shanghai Jiao Tong University; Nanjing University; Nanjing University; City University of New York (CUNY) System; College of Staten Island (CUNY)
  摘要：The ability to coherently manipulate phonons through light permits cooling and heating microscale quantum systems for various critical fields in metrology, information processing, and sensing. However, these physical systems often are hard to isolate and open for exchanging energy externally, making themselves non-Hermitian. Here, we experimentally observe a super-cooling/heating state in a non-Hermitian phononic dimer, where the two independent phonon modes of distinct cooling/heating rates b...
• A vetiver-specific terpene synthase VzTPS9 contributes to the high attractiveness of vetiver to rice stem borer AI翻译
  作者：Li, Qiang; He, Kang; Lu, Yanhui; He, Bingbing; Zheng, Xusong; Lu, Zhongxian; Li, Fei; Xu, Hongxing
  作者单位：Zhejiang University; Zhejiang University; Zhejiang Academy of Agricultural Sciences; Guizhou University
  摘要：Vetiver (Vetiveria zizanioides) is highly attractive to the rice stem borer (Chilo suppressalis, RSB) and is widely utilized as a trap plant for RSB control in East Asia. However, the underlying mechanism driving this high level of attractiveness remains unclear. In this study, we identified volatiles emitted by vetiver using SPME/GC-MS and found that cedrol constitutes 12.15% of the total volatile profile. Both Y-tube olfactometer and electroantennography assays revealed that cedrol is highly...