20期

最新文章

• MALT1 inhibitor MI-2 induces ferroptosis by direct targeting of GPX4 AI翻译
  作者：Mishima, Eikan; O'Neill, Thomas J.; Hoefig, Kai P.; Chen, Deng; Behrens, Gesine; Henkelmann, Bernhard; Ito, Junya; Nakagawa, Kiyotaka; Heissmeyer, Vigo; Conrad, Marcus; Krappmann, Daniel
  作者单位：Tohoku University; Tohoku University; University of Munich; Technical University of Munich; University of Munich
• Localized tension-induced giant folding in unstructured elastic sheets AI翻译
  作者：Guo, Kexin; Sune, Marc; Kwok, Ming Li; Hsia, K. Jimmy; Liu, Mingchao; Vella, Dominic
  作者单位：Nanyang Technological University; University of Oxford; Nanyang Technological University; University of Birmingham
  摘要：Buckling in compression is the archetype of elastic instability: when compressed along its longest dimension, a thin structure such as a playing card will buckle out-of-plane accommodating the imposed compression without a significant change of length. However, recent studies have demonstrated that tension applied to sheets with microscopic structure leads to out-of-plane deformation in applications from groovy metasheets for multistable morphing to kirigami grippers. Here, we demonstrate that...
• Structure and evolution of photosystem I in the early-branching cyanobacterium Anthocerotibacter panamensis AI翻译
  作者：Jiang, Han-Wei; Gisriel, Christopher J.; Cardona, Tanai; Flesher, David A.; Brudvig, Gary W.; Ho, Ming-Yang
  作者单位：National Taiwan University; Yale University; University of Wisconsin System; University of Wisconsin Madison; University of London; Queen Mary University London; Yale University; National Taiwan University
  摘要：Thylakoid-free cyanobacteria are thought to preserve ancestral traits of early-evolving organisms capable of oxygenic photosynthesis. However, and until recently, photosynthesis studies in thylakoid-free cyanobacteria were only possible in the model strain Gloeobacter violaceus, limiting our understanding of photosynthesis evolution. Here, report the isolation, biochemical characterization, cryo-EM structure, and phylogenetic analysis of photosystem I (PSI) from a recently discovered thylakoid...
• RNA sequencing analysis of viromes of Aedes albopictus and Aedes vexans collected from NEON sites AI翻译
  作者：Paull, Sara H.; Spurbeck, Rachel R.; Hasan, Nur A.; Brumfield, Kyle D.; Catlin, Lindsay A.; Netherland Jr, Michael J.; Smith, Anthony K.; Thibault, Katherine M.; Colwell, Rita R.
  作者单位：Battelle Memorial Institute; Battelle Memorial Institute
  摘要：Climate change is significantly impacting the geographic range of many animal species and their associated microorganisms, hence influencing emergence of vector- borne diseases. Mosquito- borne viruses represent a potential major reservoir of human pathogens, highlighting the need for improved understanding of ecological factors associated with variation in the mosquito viral community (virome). Here, a subtractive hybridization method coupled with RNAseq of individual mosquito specimens was u...
• Material- to- system tailored multilayer- cyclic strategy toward practical atmospheric water harvesting AI翻译
  作者：Zhao, Yaxuan; Guan, Weixin; Wong, Yan Zhe; Lei, Chuxin; Wang, Yuyang; Liu, Xiaomeng; Yu, Guihua
  作者单位：University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin
  摘要：Solar-driven atmospheric water harvesting (AWH) presents a sustainable approach for freshwater production with sunlight as the sole energy input. To address challenges posed by diurnal moisture variations and diffusive sunlight, we present a system-wide approach that synergistically enhances moisture capture and solar energy utilization in an integrated water harvester. Moisture utilization at the bulk sorbent scale is improved through the hierarchical pore structure of scalable biomass gel sh...
• A half- century of climate change in major agricultural regions: Trends, impacts, and surprises AI翻译
  作者：Lobell, David B.; Di Tommaso, Stefania
  作者单位：Stanford University; Stanford University
  摘要：Efforts to anticipate and adapt to future climate can benefit from historical experiences. We examine agroclimatic conditions over the past 50 y for five major crops around the world. Most regions experienced rapid warming relative to interannual variability, with 45% of summer and 32% of winter crop area warming by more than two SD (6). Vapor pressure deficit (VPD), a key driver of plant water stress, also increased in most temperate regions but not in the tropics. Precipitation trends, while...
• Electric field-induced pore constriction in the human Kv2.1 channel AI翻译
  作者：Mandala, Venkata Shiva; MacKinnon, Roderick
  作者单位：Rockefeller University; Howard Hughes Medical Institute
  摘要：Gating in voltage-dependent ion channels is regulated by the transmembrane voltage. This form of regulation is enabled by voltage-sensing domains (VSDs) that respond to transmembrane voltage differences by changing their conformation and exerting force on the pore to open or close it. Here, we use cryogenic electron microscopy to study the neuronal K(v)2.1 channel in lipid vesicles with and without a voltage difference across the membrane. Hyperpolarizing voltage differences displace the posit...
• ICT usage increases workforce geographical diversity AI翻译
  作者：Zhao, Pengjun; Wang, Hao; Clark, William A. V.; Feng, Yongheng; Liu, Qiyang; Cui, Yanzhe
  作者单位：Peking University; Peking University; Peking University Shenzhen Graduate School (PKU Shenzhen); Ministry of Natural Resources of the People's Republic of China; University of California System; University of California Los Angeles
  摘要：The adoption of information and communication technology (ICT) by rural-urban migrants is reshaping job-search mobility, significantly shaping city-level workforce geographical diversity. This study provides compelling evidence of ICT's impact by examining China's cities. We introduce the rural-urban migrant workforce Geographical Diversity Index (GDI), a metric that captures the mobility patterns of 20 million migrant workers across Chinese cities from Q1 2019 to Q4 2023. This study highlight...
• Unraveling structural transitions and kinetics along the fold-switching pathway of the RfaH C-terminal domain using exchange-based NMR AI翻译
  作者：Cai, Mengli; Ying, Jinfa; Lopez, Juan M.; Huang, Ying; Clore, G. Marius
  作者单位：National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK); Pontificia Universidad Catolica del Peru; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)
  摘要：The bacterial transcriptional regulator RfaH comprises structurally and functionally distinct N- (NTD) and C- (CTD) terminal domains. The latter switches from a helical hairpin packed against the NTD to a five-stranded beta-roll upon displacement by RNA polymerase binding. Here, we use exchange-based NMR to probe fold-switching intermediates sampled by the isolated CTD. In addition to the predominant (similar to 76 to 77%), semistable beta-roll conformation (state A), we identify four structur...
• Microscopic basis of reaction center modulation in PsbA variants of photosystem II AI翻译
  作者：Bhattacharjee, Sinjini; Gordiy, Igor; Sirohiwal, Abhishek; Pantazis, Dimitrios A.
  作者单位：Max Planck Society; Indian Institute of Science (IISC) - Bangalore
  摘要：Photosystem II (PSII) is a protein-pigment complex that utilizes sunlight to catalyze water oxidation and plastoquinone reduction, initiating the electron transfer (ET) cascade in oxygenic photosynthesis. The D1 and D2 proteins are the most important transmembrane subunits of PSII that bind all redox-active components involved in primary charge separation (CS) and ET. D1 is susceptible to oxidative photodamage, particularly under high light, and protection partly involves genetic regulation. C...