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作者：Zettler, Ingo; Lilleholt, Lau; Bader, Martina; Hilbig, Benjamin E.; Moshagen, Morten
作者单位：University of Copenhagen; University of Copenhagen; Ulm University
摘要：Humans differ in their levels of aversive (dark) personality traits such as egoism or psychopathy. Building upon theories suggesting that socioecological factors coshape the development of personality traits, it can be predicted that prior aversive societal conditions (ASC) (herein assessed via corruption, inequality, poverty, and violence) explain individuals' levels of aversive personality (assessed via the Dark Factor of Personality, the common core underlying all aversive traits). Results ...
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作者：Meng, Xue; Li, Yang; Xu, Jiuyin; Wu, Kai; Hu, Wen; Wu, Canrong; Xu, H. Eric; Xu, Youwei
作者单位：Chinese Academy of Sciences; Shanghai Institute of Materia Medica, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Fudan University; ShanghaiTech University; Shanghai Jiao Tong University; Guangzhou Medical University
摘要：Prostaglandin E2 (PGE2) mediates diverse physiological processes through four G protein-coupled receptor subtypes (EP1-EP4). While structures of EP2, EP3, and EP4 have been determined, the structural basis for PGE2 recognition and activation of the EP1 receptor subtype has remained elusive due to its inherent instability. Here, we present the cryoelectron microscopy structure of the human EP1 receptor in complex with PGE2 and heterotrimeric Gq protein at 2.55 & Aring; resolution, completing th...
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作者：Petrovic, Ivana; Tatli, Meltem; Desai, Samit; Grahl, Anne; Ni, Dongchun; Stahlberg, Henning; Spang, Anne; Grzesiek, Stephan; Abiko, Layara Akemi
作者单位：University of Basel; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; University of Lausanne
摘要：Only two nonvisual arrestins recognize many hundreds of different, intracellularly phosphorylated G protein-coupled receptors (GPCRs). Due to the highly dynamic nature of GPCR center dot arrestin complexes, the critical determinants of GPCR-arrestin recognition have remained largely unclear. We show here that arrestin2 recruitment to the R1-adrenergic receptor (R1AR) can be induced by an arrestin-activating phosphopeptide that is not covalently linked to the receptor and that the recruitment i...
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作者：Yan, Xingchi; Yu, Polly Y.; Srinivasan, Arvind; Rehman, Sohaib Abdul; Sreenivas, Surabhi Kottigegollahalli; Conway, Jeremy B.; Prigozhin, Maxim B.
作者单位：Harvard University; Harvard University; Harvard University; University of Illinois System; University of Illinois Urbana-Champaign
摘要：Intermolecular interactions underlie all cellular functions, yet visualizing these interactions at the single-molecule level remains challenging. Single-molecule localization microscopy (SMLM) offers a potential solution. Given a nanoscale map of two putative interaction partners, it should be possible to assign molecules either to the class of coupled pairs or to the class of noncoupled bystanders. Here, we developed a probabilistic algorithm that allows accurate determination of both the abs...
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作者：Xu, Luo; Zeng, Hongtai; Lin, Ning; Yang, Yue; Guo, Qinglai; Poor, H. Vincent
作者单位：Princeton University; Princeton University; Tsinghua University; Hefei University of Technology; Hefei University of Technology; Princeton University
摘要：Distribution networks, with large-scale integration of distributed renewable resources, particularly rooftop solar photovoltaic systems, represent the most extensive yet vulnerable components of modern electric power systems during climate extremes such as hurricanes. However, existing day-ahead electricity dispatch approaches primarily focus on the transmission network and lack the capability to manage the spatiotemporal risks associated with the vast distribution networks, which can potentia...
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作者：Higgs, Paul G.; Blackmond, Donna G.
作者单位：McMaster University; Scripps Research Institute
摘要：A kinetic model coupling prebiotically plausible synthesis of enantioenriched proteinogenic amino acids with catalytic peptide ligation leads to an autocatalytic network that may exhibit symmetry breaking and chiral amplification, providing a feasible route to the emergence of biological homochirality. We show that symmetry breaking leading to chiral amplification can occur in two ways: a constructive mechanism in which dimers catalyze the synthesis of monomers of the same enantiomer, and a de...
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作者：Williams, Melissa J.; Esianor, Brandon; Hendrick, Sara; Farlow, Janice L.; Farrell, Annie; Kupfer, Robbi A.; Meyer, Tanya K.; Vinson, Kimberly N.; Wandell, Grace M.; Chen, Amy Y.
作者单位：Emory University; Medical University of South Carolina; University of Northern Colorado; Indiana University System; Indiana University Indianapolis; Emory University; University of Michigan System; University of Michigan; University of Washington; University of Washington Seattle; Vanderbilt University; Swedish Medical Center
摘要：While most people believe that women (vs. men) experience more discriminatory treatment at work, especially in male-dominated professions, relatively few women report experiencing such treatment themselves. These low levels of reporting may arise either because discriminatory treatment has declined, even while laypeople's assumptions of widespread discrimination persist, or because it is difficult for individuals to know when they are experiencing discriminatory treatment, leading to underrepo...
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作者：Anderssona, Jan; Cowlanda, Sanne; Vestergaarda, Mikkel; Yangb, Yajing; Liub, Siyuan; Fangc, Xie; Mukundc, Susmith; Ghimire-Rijalb, Sudipa; Carterb, Chris; Chungb, Grace; Jacsoa, Tomas; Sarvarya, Ian; Hughesb, Paul E.; Gouliaeva, Alex; Paytonb, Marc; Belmontesb, Brian; Caenepeelb, Sean; Francha, Thomas; Glada, Sanne; Husemoena, Birgitte; Nielsena, Soren Jensby
摘要：Methylthioadenosine phosphorylase (MTAP) gene deletions are frequent in human cancers. Loss ofMTAP leads to significantly increased cellular levels of methylthioadenosine (MTA), a cellular metabolite and specific inhibitor of the cell-essential enzyme Protein Arginine Methyltransferase-5 (PRMT5). Using a cofactor-directed screening strategy and DNA-encoded libraries, we identify a class of PRMT5 inhibitors that cooperatively inhibit PRMT5 in the presence of MTA. An optimized inhibitor, AM-9934...
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作者：Royka, Amanda; Santos, Laurie R.
作者单位：Yale University
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作者：Minasandra, Pranav; Grout, Emily M.; Brock, Katrina; Crofoot, Margaret C.; Demartsev, Vlad; Gersick, Andrew S.; Hirsch, Ben T.; Holekamp, Kay E.; Johnson-Ulrich, Lily; Nayak, Amlan; Ortega, Josue; Roch, Marie A.; Strauss, Eli D.; Strandburg-Peshkin, Ariana
作者单位：Max Planck Society; University of Konstanz; Max Planck Society; University of Konstanz; Smithsonian Institution; Smithsonian Tropical Research Institute; Princeton University; James Cook University; Michigan State University; Michigan State University; University of Zurich; Indian Institute of Science Education & Research (IISER) - Mohali; California State University System; San Diego State University
摘要：Animal behavior can be decomposed into a sequence of discrete activity bouts over time. Analyzing the statistical structure of such behavioral sequences can provide insights into the drivers of behavioral decisions. Laboratory studies, predominantly in invertebrates, have suggested that behavioral sequences exhibit multiple timescales and long-range memory, but whether these results can be generalized to other taxa and to animals natural settings remains unclear. By analyzing accelerometer-inf...
