22期

最新文章

• X and Y gene dosage effects are primary contributors to human sexual dimorphism: The case of height AI翻译
  作者：Berry, Alexander S. F.; Finucane, Brenda M.; Myers, Scott M.; Martin, Christa L.; Ledbetter, David H.; Willard, Huntington F.; Oetjens, Matthew T.
  作者单位：Geisinger Health System; State University System of Florida; Florida State University
  摘要：Many human phenotypic traits vary between the sexes, including adult height for which males are, on average, 13 cm taller than females. The biological mechanisms for this sexual dimorphism are not entirely understood. One hypothesis to explain the sexual dimorphism in height relates to differential expression in males and females of SHOX, a height-related expression is reduced on the inactive X chromosome (Xi), compared to the active X in females. Sex chromosome aneuploidies (SCAs), characteri...
• Independent transitions to fully planktonic life cycles shaped the global distribution of medusozoans in the epipelagic zone AI翻译
  作者：Boosten, Manon; Sant, Camille; Da Silva, Ophelie; Chaffron, Samuel; Guidi, Lionel; Leclere, Lucas
  作者单位：Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; Nantes Universite; Centre National de la Recherche Scientifique (CNRS); Ecole Centrale de Nantes; CNRS - Institute for Information Sciences & Technologies (INS2I); Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite
  摘要：Life history traits influence marine species dispersal and habitat colonization. Medusozoans (jellyfish and siphonophores) exhibit diverse life cycles, evolved from an ancestral cycle alternating between a benthic polyp and a pelagic medusa. Despite their ecological importance, factors shaping medusozoan distribution remain poorly understood. By integrating metabarcoding and environmental data from the Tara Oceans expedition with life history traits, we provide global evidence supporting the l...
• Environmental DNA adsorption to chitin can promote horizontal gene transfer by natural transformation AI翻译
  作者：Holt, Jacob D.; Peng, Yixuan; Dalia, Triana N.; Dalia, Ankur B.; Nadell, Carey D.
  作者单位：Dartmouth College; Indiana University System; Indiana University Bloomington
  摘要：Horizontal gene transfer by natural transformation (NT) is induced in Vibrio cholerae upon attachment to chitin surfaces in the aquatic environment. Here, we show that free environmental DNA adsorbs to chitin surfaces under physiologically realistic conditions. Using live-cell imaging and a fluorescent NT reporter, we demonstrate with cellular resolution microscopy that V. cholerae utilizes chitin-bound DNA as a reservoir for genetic exchange. Additionally, we demonstrate that uptake of DNA fr...
• Solution structure and synaptic analyses reveal determinants of bispecific T cell engager potency AI翻译
  作者：Leithner, Alexander; Staufer, Oskar; Mitra, Tanmay; Liberta, Falk; Valvo, Salvatore; Kutuzov, Mikhail; Dada, Hannah; Spaeth, Jacob; Zhou, Weijie; Schiele, Felix; Reindl, Sophia; Nar, Herbert; Hoerer, Stefan; Crames, Maureen; Comeau, Stephen; Young, David; Low, Sarah; Jenkins, Edward; Davis, Simon J.; Klenerman, David; Nixon, Andrew; Pefaur, Noah; Wyatt, David; Dushek, Omer; Kasturirangan, Srinath; Dustin, Michael L.
  作者单位：University of Oxford; Kennedy Institute for Rheumatology; Leibniz Association; Leibniz Institut fur Neue Materialien (INM); Chinese Academy of Medical Sciences - Peking Union Medical College; University of Oxford; Boehringer Ingelheim; University of Oxford; Boehringer Ingelheim; University of Oxford; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); University of Oxford; University of Cambridge
  摘要：Bispecific T cell engagers (TcEs) link T cell receptors to tumor-associated antigens on cancer cells, forming cytotoxic immunological synapses (IS). Close membrane-to-membrane contact (<= 13 nm) has been proposed as a key mechanism of TcE function. To investigate this and identify potential additional mechanisms, we compared four immunoglobulin G1-based (IgG1) TcE Formats (A-D) targeting CD3 epsilon and Her2, designed to create varying intermembrane distances (A < B < C < D). Small-angle X-ray...
• High-affinity detection of biotinylated endogenous neuroligin-1 at excitatory and inhibitory synapses using a tagged knock-in mouse AI翻译
  作者：Ducrot, Charles; Drouet, Adele; Tessier, Beatrice; Desquines, Chloe; Cloatre, Tiffany; Mazouzi, Rania-Cerine; Levet, Florian; Favereaux, Alexandre; Letellier, Mathieu; Thoumine, Olivier
  作者单位：Universite de Bordeaux; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB)
  摘要：Neuroligins (NLGNs) are important cell adhesion molecules mediating trans-synaptic contacts between neurons. However, the high-yield biochemical isolation and visualization of endogenous NLGNs is hampered by the lack of efficient antibodies. Thus, to reveal their subcellular distribution, binding partners, and synaptic function, NLGNs were extensively manipulated using knock-down, knock-out, or overexpression approaches, leading to controversial results. As an alternative to the manipulation o...
• A whole-scale volatile-depleted lunar interior AI翻译
  作者：Dai, Wei; Moynier, Frederic; Long, Zheng- Yu; Fang, Linru; Day, James M. D.; Paquet, Marine; Siebert, Julien
  作者单位：Universite Paris Cite; Centre National de la Recherche Scientifique (CNRS); University of Copenhagen; University of California System; University of California San Diego; Scripps Institution of Oceanography; Centre National de la Recherche Scientifique (CNRS); Universite de Lorraine
  摘要：The extent of moderately volatile elements (MVE) depletion and its effects on the Moon's evolutionary history remain contentious, partly due to unintentionally biased sampling by the Apollo missions from the Procellarum KREEP Terrane. In this study, we analyzed the Zn and K isotope compositions of a series of lunar basaltic meteorites, which vary in Th content and are likely to represent a broader sampling range than previous studies, including samples from the far side of the Moon. Our findin...
• Maximum spreading of impacting shear-thinning and shear-thickening drops AI翻译
  作者：Mobaseri, Anahita; Kumar, Satish; Cheng, Xiang
  作者单位：University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities
  摘要：The maximum spreading of an impacting liquid drop is a key metric for characterizing the fundamental fluid process of drop impact. While extensively studied for Newtonian liquids, how far a non-Newtonian drop can spread upon impacting a solid substrate remains an open question. Here, by combining simulations, experiments, and scaling analyses, we establish a general framework for predicting the maximum spreading of drops of generalized Newtonian liquids, encompassing both shear-thinning and sh...
• Further exploration of the principles and mechanisms of brainwashing AI翻译
  作者：Liu, Haitao; Sun, Haogeng; Liu, Yi
  作者单位：Sichuan University; Sichuan University
• Molecular basis for ligand recognition and receptor activation of the prostaglandin D2 receptor DP1 AI翻译
  作者：Xu, Jiuyin; Wu, Yanli; Xu, Youwei; Li, Yang; He, Xinheng; Zhang, Heng; Wang, James Jiqi; Hou, Jingjing; Li, Junrui; Hu, Wen; Wu, Kai; Yuan, Qingning; Wu, Canrong; Xu, H. Eric
  作者单位：Chinese Academy of Sciences; Shanghai Institute of Materia Medica, CAS; ShanghaiTech University; Huazhong University of Science & Technology; Huazhong University of Science & Technology; Fudan University; Shanghai Jiao Tong University; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
  摘要：The prostaglandin D2 receptor 1 (DP1), a rhodopsin-like Class A GPCR, orchestrates critical physiological and pathological processes, ranging from sleep regulation to inflammatory responses and cardiovascular function. Despite its therapeutic significance, structural insights into DP1 activation mechanisms have remained elusive. Here, using cryoelectron microscopy (cryo-EM), we determined high-resolution structures of human DP1 in both inactive and active states, with the latter captured in co...
• CRISPR screen reveals a simultaneous targeted mechanism to reduce cancer cell selenium and increase lipid oxidation to induce ferroptosis AI翻译
  作者：Lamperis, Sophia M.; Mcmahon, Kaylin M.; Calvert, Andrea E.; Rink, Jonathan S.; Vasan, Karthik; Pandkar, Madhura R.; Crentsil, Eliana U.; Chalmers, Zachary R.; Mcdonald, Natalie R.; Kosmala, Cameron J.; Bonini, Marcelo G.; Matei, Daniela; Gordon, Leo I.; Chandel, Navdeep S.; Thaxton, C. Shad
  作者单位：Northwestern University; Feinberg School of Medicine; Northwestern University; Feinberg School of Medicine; Northwestern University; Ann & Robert H. Lurie Children's Hospital of Chicago; Robert H. Lurie Comprehensive Cancer Center; Feinberg School of Medicine; Northwestern University; Feinberg School of Medicine; Northwestern University; Feinberg School of Medicine; Northwestern University; Feinberg School of Medicine; Northwestern University; Feinberg School of Medicine; US Department of Veterans Affairs; Veterans Health Administration (VHA); Jesse Brown VA Medical Center
  摘要：Ferroptosis is a cell death mechanism distinguished by its dependence on iron-mediated lipid oxidation. Cancer cells highly resistant to conventional therapies often demonstrate lipid metabolic and redox vulnerabilities that sensitize them to cell death by ferroptosis. These include a unique dependency on the lipid antioxidant selenoenzyme, glutathione peroxidase 4 (GPx4), that acts as a ferroptosis inhibitor. Synthetic high-density lipoprotein-like nanoparticle (HDL NP) targets the high-affin...