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作者：Broka, Derrick; Klein, Shoshana; Shir, Alexei; Schade, Babette; Saxena, Meera; Dasargyri, Athanasia; Jarzebinska, Anita; De Feyter, Caroline; Bajic, Davor; Colecchia, David; Amico, Lucia D.; Kitas, Eric; Hikri, Elad; Skowicki, Michal Jerzy; Okoniewski, Michal Jerzy; Baldino, Laura; Qeriqi, Besnik; de Stanchina, Elisa; Schreiber, Joerg; Buchi, Melanie; Palivan, Cornelia G.; Benenson, Yaakov; Zippelius, Alfred; Fabbro, Doriano; Scaltriti, Maurizio; Mizrachi, Aviram; Levitzki, Alexander; Pombo-Villar, Esteban; Zigler, Maya
作者单位：Hebrew University of Jerusalem; Rabin Medical Center; Tel Aviv University; Rabin Medical Center; Tel Aviv University; University of Basel; Swiss Federal Institutes of Technology Domain; ETH Zurich; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Basel
摘要：Aberrant activation and overexpression of the epidermal growth factor receptor (EGFR) occurs in various solid cancers and often correlates with poor outcome. The clinical benefit from EGFR-targeted therapies is usually short-lived, with resistance being driven by tumor heterogeneity and an immunosuppressive tumor microenvironment (TME). To address these limitations, we developed Targeted Apoptotic Immune Modulators (TAIM), a nonviral nanoparticle platform for the targeted delivery of polyinosi...
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作者：Scheidegger, Alan; V. Golubev, Nikolay; Makri, Nancy
作者单位：Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; University of Arizona
摘要：Coherent superposition of electronic states, created by ionizing a molecule, can initiate ultrafast dynamics of the electron density. Correlation between nuclear and electron motions, however, typically dissipates the electronic coherence in only a few femtoseconds, especially in larger and more flexible molecules. We, therefore, use ab initio semiclassical dynamics to study decoherence in a sequence of analogous organic molecules of increasing size and find, surprisingly, that extending the c...
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作者：Xue, Lingfeng; Yan, Nieng; Song, Chen
作者单位：Peking University; Tsinghua University; Shenzhen Medical Academy of Research & Translation (SMART); Shenzhen Bay Laboratory
摘要：Voltage-gated calcium (CaV) channels are pivotal in cellular signaling due to their selective calcium ion permeation upon membrane depolarization. While previous studies have established the highly selective permeability of CaV channels, the detailed molecular mechanism remains elusive. Here, we use extensive atomistic molecular dynamics simulations to elucidate the mechanisms governing ion permeation and valence selectivity in CaV1 channels. Employing the electronic continuum correction metho...
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作者：Ding, Huixia; Zhang, Zeming; Kohn, Matthew J.
作者单位：China University of Geosciences; China University of Geosciences; China Geological Survey; Institute of Geology, Chinese Academy of Geological Sciences; Chinese Academy of Geological Sciences; Boise State University
摘要：Partial melting of metasedimentary rocks is generally accepted as the source of peraluminous Himalayan leucogranites-they are commonly considered as pure S-type (sedimentary source) granites. Here, a uniquely comprehensive geochronological and geochemical dataset shows that partial melting of metaigneous rocks in the eastern Himalaya produced peraluminous leucogranites-these supposed S-type leucogranites have I-type (igneous) sources. Inherited magmatic zircons from leucogranites and metaigneo...
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作者：Dai, Wei; Moynier, Frederic; Long, Zheng- Yu; Fang, Linru; Day, James M. D.; Paquet, Marine; Siebert, Julien
作者单位：Universite Paris Cite; Centre National de la Recherche Scientifique (CNRS); University of Copenhagen; University of California System; University of California San Diego; Scripps Institution of Oceanography; Universite de Lorraine; Centre National de la Recherche Scientifique (CNRS)
摘要：The extent of moderately volatile elements (MVE) depletion and its effects on the Moon's evolutionary history remain contentious, partly due to unintentionally biased sampling by the Apollo missions from the Procellarum KREEP Terrane. In this study, we analyzed the Zn and K isotope compositions of a series of lunar basaltic meteorites, which vary in Th content and are likely to represent a broader sampling range than previous studies, including samples from the far side of the Moon. Our findin...
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作者：Mobaseri, Anahita; Kumar, Satish; Cheng, Xiang
作者单位：University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities
摘要：The maximum spreading of an impacting liquid drop is a key metric for characterizing the fundamental fluid process of drop impact. While extensively studied for Newtonian liquids, how far a non-Newtonian drop can spread upon impacting a solid substrate remains an open question. Here, by combining simulations, experiments, and scaling analyses, we establish a general framework for predicting the maximum spreading of drops of generalized Newtonian liquids, encompassing both shear-thinning and sh...
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作者：Liu, Haitao; Sun, Haogeng; Liu, Yi
作者单位：Sichuan University; Sichuan University
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作者：Sharma, Babita; Aswin, Keerthic; Jain, Tanya; Nasreen, Ayesha; Aggarwal, Ayush; Subramaniam, Yogaspoorthi J.; Rengaraju, Jeyashri; Agrawal, Srashti Jyoti; Bhatt, Mayank; Paul, Bhashkar; Chandrasekaran, Koushika; Yadav, Aanchal; Soni, Jyoti; Ujjainiya, Rajat; Akhter, Md Quasid; Pandey, Rajesh; Suresh, Shruthy; Sampathkumar, Srinivasa -- Gopalan; Natarajan, Vivek T.
作者单位：Council of Scientific & Industrial Research (CSIR) - India; CSIR - Institute of Genomics & Integrative Biology (IGIB); Academy of Scientific & Innovative Research (AcSIR); Department of Biotechnology (DBT) India; National Institute of Immunology (NII)
摘要：Melanocyte development involves key pathways that are often recapitulated during melanoma initiation, highlighting the importance of understanding these regulatory processes. Our study identifies mgat4b, a glycosyl transferase involved in selective N-glycan branching enriched in pigment progenitors, as a regulator of directional cell migration and establishment of melanocyte stem cell (McSC) pool during early development. Single cell RNA (scRNA) sequencing analysis in zebrafish upon targeted d...
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作者：Xing, Yikun; Santos, Haroldo J. Hernandez; Qiu, Ling; Ritter, Samantha R.; Zulk, Jacob J.; Lahowetz, Rachel; Patras, Kathryn A.; Terwilliger, Austen L.; Maresso, Anthony W.
作者单位：Baylor College of Medicine; Baylor College of Medicine; Baylor College of Medicine
摘要：Bacteriophages, or phages, are viruses that target and infect bacteria. Due to a worldwide rise in antimicrobial resistance (AMR), phages have been proposed as a promising alternative to antibiotics for the treatment of resistant bacterial infections. Up to this point in history, phage use in preclinical animal studies, clinical trials, and emergency- use compassionate care cases has centered around the original observation from 1915 showing phage as lytic agent, and thus a treatment that kill...
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作者：Stewart, Robert G.; Osorno, Tomas; Fujita, Akie; Jo, Sooyeon; Ferraiuolo, Alyssa; Carlin, Kevin; Bean, Bruce P.
作者单位：Harvard University; Harvard Medical School
摘要：Nav1.8 voltage-gated sodium channels are strongly expressed in human primary pain-sensing neurons (nociceptors) and a selective Nav1.8 inhibitor VX-548 (suzetrigine) has shown efficacy for treating acute pain in clinical trials. Nociceptors also express other sodium channels, notably Nav1.7, raising the question of how effectively excitability of the neurons is reduced by inhibition of Nav1.8 channels alone. We used VX-548 to explore this question, recording from dissociated human dorsal root ...
