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作者：Xue, Lingfeng; Yan, Nieng; Song, Chen
作者单位：Peking University; Tsinghua University; Shenzhen Medical Academy of Research & Translation (SMART); Shenzhen Bay Laboratory
摘要：Voltage-gated calcium (CaV) channels are pivotal in cellular signaling due to their selective calcium ion permeation upon membrane depolarization. While previous studies have established the highly selective permeability of CaV channels, the detailed molecular mechanism remains elusive. Here, we use extensive atomistic molecular dynamics simulations to elucidate the mechanisms governing ion permeation and valence selectivity in CaV1 channels. Employing the electronic continuum correction metho...
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作者：Ding, Huixia; Zhang, Zeming; Kohn, Matthew J.
作者单位：China University of Geosciences; China University of Geosciences; China Geological Survey; Chinese Academy of Geological Sciences; Institute of Geology, Chinese Academy of Geological Sciences; Boise State University
摘要：Partial melting of metasedimentary rocks is generally accepted as the source of peraluminous Himalayan leucogranites-they are commonly considered as pure S-type (sedimentary source) granites. Here, a uniquely comprehensive geochronological and geochemical dataset shows that partial melting of metaigneous rocks in the eastern Himalaya produced peraluminous leucogranites-these supposed S-type leucogranites have I-type (igneous) sources. Inherited magmatic zircons from leucogranites and metaigneo...
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作者：Munn, Lance L.
作者单位：Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School
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作者：Long, Zhengkun; Northoff, Georg; Fu, Xiaolan
作者单位：Chinese Academy of Sciences; Nanjing Institute of Geology & Paleontology, CAS; Institute of Psychology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Shenzhen University; University of Ottawa; Shanghai Jiao Tong University
摘要：Mind wandering attenuates widespread sensory and motor processing, both of which are mediated by phase coherence. However, it remains unclear i) whether mind wandering impacts both sensory input and motor output processing by modulating ii) neural entrainment to external stimuli, as measured by intertrial phase coherence (ITPC), and specifically iii) whether task difficulty with different degrees of attentional demands moderates the impact of mind wandering on phase coherence. Using the though...
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作者：Aderounmu, Adedeji M.; Maus-Conn, Josephine; Consalvo, Claudia D.; Shen, Peter S.; Bass, Brenda L.
作者单位：Utah System of Higher Education; University of Utah
摘要：A fully functional Dicer helicase, present in the modern arthropod, uses energy from ATP hydrolysis to power translocation on bound dsRNA, enabling the processive dsRNA cleavage required for efficient antiviral defense. However, modern Dicer orthologs exhibit divergent helicase functions that affect their ability to contribute to antiviral defense. Moreover, mechanisms that couple ATP hydrolysis to Dicer helicase movement on dsRNA remain enigmatic. We used biochemical and structural analyses o...
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作者：Li, Bingjie; Su, Jiaji; Lin, Runyu; Yau, Shing-Tung; Yao, Zhigang
作者单位：National University of Singapore; Tsinghua University
摘要：NMR-based metabolic biomarkers provide comprehensive insights into human metabolism; however, extracting biologically meaningful patterns from such highdimensional data remains a significant challenge. In this study, we propose a manifold-fitting-based framework to analyze metabolic heterogeneity within the UK participants. Initially, our method clusters these biomarkers into seven distinct metabolic categories that reflect the modular organization of human metabolism. Subsequent manifold fitt...
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作者：Piantino, Juan
作者单位：Oregon Health & Science University
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作者：He, Biao; Li, Meilin; Guo, Shuai; Zhu, Feng; Jiao, Zhiwei; Li, Jianyong; Tan, Nie; Jiao, Shiming; Liu, Taiping; Zhang, Jian; Fan, Yongling; Gao, Yuanli; Zhou, Taoli; Li, Jian; Huang, Wei; Jiang, Lubin; Lin, Zurui; Wang, Sibao; Xu, Wenyue
作者单位：Army Medical University; Xiamen University; Chinese Academy of Sciences; Pasteur Network; Shanghai Institute of Immunity and Infection, CAS; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Center for Excellence in Molecular Plant Sciences, CAS
摘要：Host-derived factors ingested during mosquito blood feeding are poorly understood modulators of malaria transmission. Here, we demonstrated that host complement C3, acquired by mosquitoes during Plasmodium infection, significantly enhanced rodent malaria infection in laboratory-reared mosquitoes. This effect was recapitulated in field-caught Anopheles sinensis mosquitoes, confirming its relevance to malaria transmission in a more natural setting. Moreover, host-derived C3 significantly reduced...
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作者：Moser, Tobias; Roos, Lennart
作者单位：University of Gottingen; University of Gottingen Hospital; University of Gottingen; University of Gottingen; University of Gottingen Hospital; University of Gottingen; University of Gottingen Hospital
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作者：Escamilla-Vega, Elio; Seton, Louk W. G.; Kyomen, Stella; Murillo-Rincon, Andrea P.; Petersen, Julian; Tautz, Diethard; Kaucka, Marketa
作者单位：Max Planck Society; Leipzig University
摘要：The tight link between brain and skull formation is a fundamental aspect of vertebrate evolution and embryogenesis. Their developmental synchronization is essential for structural and functional integration. The brain and skull shape coevolution is evident along the vertebrate phylogeny; however, the genetic basis underlying their close evolutionary and developmental relationship remains little explored. Here, we reveal the evolution and function of the MN1 gene that was previously found to be...
