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作者：Barzilay, Yuval; Eyal, Zohar; Noy, Yael; Varsano, Neta; Olender, Tsviya; Bera, Sourabh; Lerer-Goldshtein, Tali; Kedmi, Merav; Porat, Ziv; Pinkas, Iddo; Levin-Zaidman, Smadar; Dezorella, Nili; Gur, Dvir
作者单位：Weizmann Institute of Science; Weizmann Institute of Science; Weizmann Institute of Science
摘要：Pigmentation plays a vital role in the survival of organisms, supporting functions such as camouflage, communication, and mate attraction. In vertebrates, these functions are mediated by specialized pigment cells known as chromatophores of which, uric acid crystal-forming leucophores remain the least understood, with little known about their molecular mechanisms. A key question in pigment cell biology is whether different crystal chemistries require distinct molecular pathways, or whether simi...
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作者：Sharma, Babita; Aswin, Keerthic; Jain, Tanya; Nasreen, Ayesha; Aggarwal, Ayush; Subramaniam, Yogaspoorthi J.; Rengaraju, Jeyashri; Agrawal, Srashti Jyoti; Bhatt, Mayank; Paul, Bhashkar; Chandrasekaran, Koushika; Yadav, Aanchal; Soni, Jyoti; Ujjainiya, Rajat; Akhter, Md Quasid; Pandey, Rajesh; Suresh, Shruthy; Sampathkumar, Srinivasa -- Gopalan; Natarajan, Vivek T.
作者单位：Council of Scientific & Industrial Research (CSIR) - India; CSIR - Institute of Genomics & Integrative Biology (IGIB); Academy of Scientific & Innovative Research (AcSIR); Department of Biotechnology (DBT) India; National Institute of Immunology (NII)
摘要：Melanocyte development involves key pathways that are often recapitulated during melanoma initiation, highlighting the importance of understanding these regulatory processes. Our study identifies mgat4b, a glycosyl transferase involved in selective N-glycan branching enriched in pigment progenitors, as a regulator of directional cell migration and establishment of melanocyte stem cell (McSC) pool during early development. Single cell RNA (scRNA) sequencing analysis in zebrafish upon targeted d...
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作者：Xing, Yikun; Santos, Haroldo J. Hernandez; Qiu, Ling; Ritter, Samantha R.; Zulk, Jacob J.; Lahowetz, Rachel; Patras, Kathryn A.; Terwilliger, Austen L.; Maresso, Anthony W.
作者单位：Baylor College of Medicine; Baylor College of Medicine; Baylor College of Medicine
摘要：Bacteriophages, or phages, are viruses that target and infect bacteria. Due to a worldwide rise in antimicrobial resistance (AMR), phages have been proposed as a promising alternative to antibiotics for the treatment of resistant bacterial infections. Up to this point in history, phage use in preclinical animal studies, clinical trials, and emergency- use compassionate care cases has centered around the original observation from 1915 showing phage as lytic agent, and thus a treatment that kill...
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作者：Stewart, Robert G.; Osorno, Tomas; Fujita, Akie; Jo, Sooyeon; Ferraiuolo, Alyssa; Carlin, Kevin; Bean, Bruce P.
作者单位：Harvard University; Harvard Medical School
摘要：Nav1.8 voltage-gated sodium channels are strongly expressed in human primary pain-sensing neurons (nociceptors) and a selective Nav1.8 inhibitor VX-548 (suzetrigine) has shown efficacy for treating acute pain in clinical trials. Nociceptors also express other sodium channels, notably Nav1.7, raising the question of how effectively excitability of the neurons is reduced by inhibition of Nav1.8 channels alone. We used VX-548 to explore this question, recording from dissociated human dorsal root ...
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作者：Winsor, Nathaniel J.; Tsang, Derek K.; Ranger, Adrienne; Singh, Ojas; Goyal, Shawn; Philpott, Dana J.; Girardin, Stephen E.
作者单位：University of Toronto; University of Toronto
摘要：Upon injury, epithelial-derived IL-18 is released and induces an inflammatory response in underlying IL18R1+ lamina propria cells. Notably, Il18r1 is also predicted to be expressed and functional in intestinal epithelial cells (IECs), since epithelial IL18R1 deficiency contributes to worsened outcomes upon inflammatory challenge. However, the nature of Il18r1+ IECs, and their subsequent role in epithelial-intrinsic IL-18 signaling is poorly characterized. Here, we show that, in the murine smal...
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作者：Bonetti, Pietro M.; Christos, Maine; Sachdev, Subir
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作者：Davis, Megan M.; Woodburn, Mackenzie; Nugiel, Tehila; Rakesh, Divyangana; Tate, Maresa; Asciutto, William; Lin, Weili; Cohen, Jessica R.; Sheridan, Margaret A.
作者单位：University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; State University System of Florida; Florida State University; University of London; King's College London; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine
摘要：The human cortex undergoes immense change in the first years of life, doubling in thickness within the first year and evidencing the greatest change within the first 5 y. While substantial research has identified the early postnatal period as a sensitive period in cortical development, research to date lacks the temporal resolution necessary to identify which aspects of cortical change predict later neural and cognitive function. This study leveraged a rich longitudinal dataset of cortical thi...
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作者：Hoshikawa, Yojiro; Shirota, Natsuho; Tsugawa, Hiroshi; Kimura, Satoshi; Matsuyama, Akihisa; Yashiroda, Yoko; Kakeya, Hideaki; Arita, Makoto; Iizumi, Reiko; Yoshida, Minoru; Nishimura, Shinichi
作者单位：University of Tokyo; Hiroshima University; Hiroshima University; RIKEN; RIKEN; Yokohama City University; Tokyo University of Agriculture & Technology; University of Tokyo; RIKEN; Kyoto University; Keio University; Keio University; University of California System; University of California San Diego; Scripps Institution of Oceanography; University of Tokyo; University of Tokyo; RIKEN
摘要：Excess amounts of saturated fatty acids (FAs) are toxic to organisms, a condition termed lipotoxicity, which is often accompanied by pleiotropic cellular and tissue dysfunction. Here, we show that pentadecanoic acid (C15:0) exerts toxicity on the fission yeast Schizosaccharomyces pombe by generating an aberrantly planar endoplasmic reticulum (ER) structure, which we named a giant ER sheet. Untargeted lipidomics revealed that C15:0 is incorporated into complex lipids depending on an acyl- CoA l...
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作者：Montanarella, Antonino F.; Hundt, Nikolas; Keim, Dominik; Venczel, Aron; Zierhut, Felix; Langnickel, Simon; Graw, Andreas; Kroess, Markus; Dietrich, Johannes; Saczko, Dario; Veigel, Claudia
作者单位：University of Munich; University of Munich
摘要：Mitochondrial damage determines cell fate, leading to mitochondrial autophagy or cellular apoptosis in health and disease. The molecular mechanisms and role of the acto-myosin cytoskeleton regulating mitochondrial clearance and membrane remodeling are critical in neurodegenerative disease progression including Alzheimer, but remain unclear. To investigate the potential link between full-length Myosin VI (FL-Myo6) recruitment and exposure of the mitochondria-specific lipid cardiolipin (CL), her...
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作者：Alverson, Andrew J.; Roberts, Wade R.; Ruck, Elizabeth C.; Nakov, Teofil; Ashworth, Matthew P.; Brylka, Karolina; Downey, Kala M.; Kociolek, J. Patrick; Parks, Matthew; Pinseel, Eveline; Theriot, Edward C.; Tye, Simon P.; Witkowski, Andrzej; Beaulieu, Jeremy M.; Wickett, Norman J.
作者单位：University of Arkansas System; University of Arkansas Fayetteville; Universidad Costa Rica; University of Texas System; University of Texas Austin; Lund University; University of Colorado System; University of Colorado Boulder; University of Central Oklahoma; Ghent University; University of Texas System; University of Texas Austin; University of Szczecin; University of Vienna
摘要：Evolution is often uneven in its pace and outcomes, with long periods of stasis interrupted by abrupt increases in morphological and ecological disparity. With thousands of gene histories, phylogenomics can uncover the genomic signatures of these broad macroevolutionary trends. Diatoms are a species- rich lineage of microeukaryotes that contribute greatly to the global cycling of carbon, oxygen, and silica, which they use to build elaborately structured cell walls. We combined fossil informati...
