22期

最新文章

• ATP8B1 regulates PIP2 localization and cleavage of pyroptotic executioner Gasdermin D AI翻译
  作者：Bhandari, Nilam; Prince, Ashutosh; Khan, Mariam R.; Traughber, C. Alicia; Neupane, Kalash; Lorkowski, Shuhui W.; Brubaker, Gregory; Ertugral, Elif G.; Kothapalli, Chandrasekhar R.; Dubyak, George R.; Smith, Jonathan D.; Gulshan, Kailash
  作者单位：University System of Ohio; Cleveland State University; University System of Ohio; Cleveland State University; Cleveland Clinic Foundation; University System of Ohio; Cleveland State University; University System of Ohio; Case Western Reserve University
  摘要：Mutations in ATP8B1 cause progressive familial intrahepatic cholestasis, with symptoms including pruritus, pancreatitis, fat malabsorption, intestinal inflammation, and failure to thrive. High-throughput studies showed interconnection between ATP8B1 and phosphoinositide (PIPs), but the mechanism linking ATP8B1, lipid metabolism, and inflammation remains unclear. Atp8b1G308V/G308Vmouse model, unbiased RNAseq, high-resolution-stimulation emission depltion (STED)-microscopy, and Crispr-Cas9 gener...
• Surface melting-driven hydrogen absorption for high-pressure polyhydride synthesis AI翻译
  作者：Sato, Ryuhei; Conway, Lewis J.; Zhang, Di; Pickard, Chris J.; Akagi, Kazuto; Sau, Kartik; Li, Hao; Orimo, Shin - ichi
  作者单位：Tohoku University; University of Tokyo; University of Cambridge; National Institute of Advanced Industrial Science & Technology (AIST); Tohoku University; Tohoku University
  摘要：The synthesis of new polyhydrides with high superconducting Tc is challenging owing to the high pressures and temperatures required. In this study, we used machine-learning potential molecular dynamics simulations to investigate the initial stage of polyhydride formation in calcium hydrides. Upon contact with high-pressure H2, the surface of CaH2 melts, leading to CaH4 formation. This surface melting proceeds via CaH4 liquid phase as an intermediate state. High pressure reduces not only the hy...
• Ecological restructuring of North Tethyan marine vertebrate communities triggered by the end- Cretaceous extinction AI翻译
  作者：Feichtinger, Iris; Harzhauser, Mathias; Pollerspock, Jurgen; Auer, Gerald; Coric, Stjepan; Kranner, Matthias; Kallanxhi, Madalina-Elena; Weinmann, Anna E.; Guinot, Guillaume
  作者单位：University of Graz; Centre National de la Recherche Scientifique (CNRS); Institut de Recherche pour le Developpement (IRD); Universite de Montpellier; Institut Universitaire de France
  摘要：The ecological upheavals produced by the Cretaceous-Paleogene mass extinction event (K-Pg, -66 Ma) have been mostly studied at large scale with emphasis on clades' diversity dynamics. How this event affected the structure of paleocommunities is comparatively less investigated, especially within large vertebrate clades like fish. Here, we quantified changes in the contribution of elasmobranchs (sharks, skates, rays) and actinopterygians (ray-finned fishes) to the fish community across the K-Pg ...
• Manifold fitting reveals metabolomic heterogeneity and disease associations in UK Biobank populations AI翻译
  作者：Li, Bingjie; Lin, Runyu; Yau, Shing-Tung; Yao, Zhigang
  作者单位：National University of Singapore; Tsinghua University
  摘要：NMR-based metabolic biomarkers provide comprehensive insights into human metabolism; however, extracting biologically meaningful patterns from such highdimensional data remains a significant challenge. In this study, we propose a manifold-fitting-based framework to analyze metabolic heterogeneity within the UK participants. Initially, our method clusters these biomarkers into seven distinct metabolic categories that reflect the modular organization of human metabolism. Subsequent manifold fitt...
• Reply to Liu et al.: Visualization of cerebral perivascular spaces following administration of intrathecal contrast AI翻译
  作者：Piantino, Juan
  作者单位：Oregon Health & Science University
• Exploring diverse supramolecular tessellation through hierarchical assemblies of nonalternant nanographene AI翻译
  作者：Sun, Jian; Deng, Ziqi; Phillips, David Lee; Liu, Junzhi
  作者单位：Chinese Academy of Sciences; University of Hong Kong; University of Hong Kong; University of Hong Kong; University of Hong Kong; The University of Hong Kong Shenzhen Institute of Research & Innovation
  摘要：Tessellation, as an ancient and fascinating mathematical pursuit, has not only captivated mathematicians but also has attracted chemists' increasing attention at the molecular level in recent years. Exploring tessellation at the molecular scale is pivotal for gaining profound insights into the effects of tessellation on materials and elucidating the essential design principles for supramolecular tessellation. In this study, we develop a dynamic fullerene host (1) with three consecutive heptago...
• Rhomboid-mediated cleavage of the immune receptor XA21 protects grain set and male fertility in rice AI翻译
  作者：Vergish, Satyam; Huang, Xiaoen; Zhang, Guiyun; Franceschi, Beatriz de Toledo; Li, Jian-Liang; Wu, Xiao-Xia; Nuraj, Joana; Huguet-Tapia, Jose C.; Parajuli, Apekshya; Chen, Xiuhua; Shekhar, Ritu; Liu, Dali; Xiao, Wu-Ming; Dou, Shijuan; Liu, Guo-zhen; Goss, Erica M.; Pi, Liya; Chen, Sixue; Koch, Karen E.; Song, Wen- Yuan
  作者单位：State University System of Florida; University of Florida; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS); State University System of Florida; University of Florida; Hebei Agricultural University; State University System of Florida; University of Florida; Tulane University; University of Mississippi; State University System of Florida; University of Florida; State University System of Florida; University of Florida; State University System of Florida; University of Florida; Yangzhou University; State University System of Florida; Florida International University; Heilongjiang University; South China Agricultural University
  摘要：To maintain growth and to successfully reproduce, organisms must protect key functions in specific tissues, particularly when countering pathogen invasion using internal defensive proteins that may disrupt their own developmental processes. The rice immune receptor XA21 confers race-specific resistance against Xanthomonas oryzae pv. oryzae, which causes the deadly disease bacterial leaf blight. Here, we demonstrate that XA21 is cleaved by the rhomboid-like protease OsRBL3b, likely within its t...
• Label-free high-throughput live-cell sorting of genome-wide random mutagenesis libraries for metabolic traits by Raman flow cytometry AI翻译
  作者：Wang, Xixian; Wang, Sen; Diao, Zhidian; Hou, Xibao; Gong, Yanhai; Sun, Qing; Zhang, Jiaping; Ren, Lihui; Li, Yuandong; Ji, Yuetong; Shen, Wei; Yin, Yifeng; Huang, Shi; Song, Xiaojin; Cui, Qiu; Feng, Yingang; Xu, Jian; Ma, Bo
  作者单位：Chinese Academy of Sciences; Qingdao Institute of Bioenergy & Bioprocess Technology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; University of Hong Kong
  摘要：A full spontaneous single-cell Raman spectrum captures the metabolic phenome in a label-free and noninvasive manner. However, Raman-activated cell sorting (RACS) of rare target cells from highly heterogeneous systems has remained largely conceptual. Here, we present a positive dielectrophoresis-induced deterministic lateral displacement (pDEP-DLD)-based RACS (pDEP-DLD-RACS), in which a modulated pDEP-DLD force is applied to focus, trap, and functionally sort fast-moving single cells in a wide ...
• Self- reproduction as an autonomous process of growth and reorganization in fully abiotic, artificial and synthetic cells AI翻译
  作者：Katla, Sai Krishna; Lin, Chenyu; Perez-Mercader, Juan
  作者单位：Harvard University; The Santa Fe Institute
  摘要：We investigate mechanisms for the observed nonlinear growth in the number of polymer vesicles generated during a photo- Reversible Addition- Fragmentation Chain Transfer- based polymerization- induced self- assembly (PISA) reaction. Our experimental results reveal the presence of a self- reproduction process during which chemically active polymer protocells are chemically and autonomously generated in a light- stimulated one- pot reaction that starts from a homogeneous blend of non- self- asse...
• Alternative cGAS signaling promotes herpes simplex encephalitis AI翻译
  作者：Shmuel-Galia, Liraz; Jiang, Zhaozhao; Stine, Laurel; Cahill, Sara; Ng, Sze - Ling; Wilson, Ruth; Kandasamy, Richard Kumaran; Kurt-Jones, Evelyn A.; Ramanjulu, Joshi M.; Bertin, John; Kasparcova, Viera; Pesiridis, G. Scott; Fitzgerald, Katherine A.; Humphries, Fiachra
  作者单位：University of Massachusetts System; University of Massachusetts Worcester; UMass Chan Medical School; GlaxoSmithKline; Glaxosmithkline USA; Norwegian University of Science & Technology (NTNU); Norwegian University of Science & Technology (NTNU); University of Massachusetts System; UMass Chan Medical School; University of Massachusetts Worcester; Sanofi-Aventis; Sanofi USA
  摘要：During infection, foreign DNA is sensed by cyclic GMP-AMP synthase (cGAS) leading to the production of cGAMP, STING-dependent type I interferon and proinflammatory cytokine expression, and autophagy. To prevent a response to self-DNA, cGAS activity is tightly regulated. Dysregulation of cGAS underpins interferonopathies, such as Aicardi-Gouti & egrave;res syndrome, as well as Lupus and neurodegenerative diseases like Parkinson's disease. Thus, cGAS and its product cGAMP are therapeutic targets...