22期

最新文章

• Longitudinal associations between birth- to- six cortical growth and childhood neurocognitive function AI翻译
  作者：Davis, Megan M.; Woodburn, Mackenzie; Nugiel, Tehila; Rakesh, Divyangana; Tate, Maresa; Asciutto, William; Lin, Weili; Cohen, Jessica R.; Sheridan, Margaret A.
  作者单位：University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; State University System of Florida; Florida State University; University of London; King's College London; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine
  摘要：The human cortex undergoes immense change in the first years of life, doubling in thickness within the first year and evidencing the greatest change within the first 5 y. While substantial research has identified the early postnatal period as a sensitive period in cortical development, research to date lacks the temporal resolution necessary to identify which aspects of cortical change predict later neural and cognitive function. This study leveraged a rich longitudinal dataset of cortical thi...
• Formation of giant ER sheets by pentadecanoic acid causes lipotoxicity in fission yeast AI翻译
  作者：Hoshikawa, Yojiro; Shirota, Natsuho; Tsugawa, Hiroshi; Kimura, Satoshi; Matsuyama, Akihisa; Yashiroda, Yoko; Kakeya, Hideaki; Arita, Makoto; Iizumi, Reiko; Yoshida, Minoru; Nishimura, Shinichi
  作者单位：University of Tokyo; Hiroshima University; Hiroshima University; RIKEN; RIKEN; Yokohama City University; Tokyo University of Agriculture & Technology; University of Tokyo; RIKEN; Kyoto University; Keio University; Keio University; University of California System; University of California San Diego; Scripps Institution of Oceanography; University of Tokyo; University of Tokyo; RIKEN
  摘要：Excess amounts of saturated fatty acids (FAs) are toxic to organisms, a condition termed lipotoxicity, which is often accompanied by pleiotropic cellular and tissue dysfunction. Here, we show that pentadecanoic acid (C15:0) exerts toxicity on the fission yeast Schizosaccharomyces pombe by generating an aberrantly planar endoplasmic reticulum (ER) structure, which we named a giant ER sheet. Untargeted lipidomics revealed that C15:0 is incorporated into complex lipids depending on an acyl- CoA l...
• Cardiolipin membranes drive Myosin VI activation, oligomerization, and processive cargo transport AI翻译
  作者：Montanarella, Antonino F.; Hundt, Nikolas; Keim, Dominik; Venczel, Aron; Zierhut, Felix; Langnickel, Simon; Graw, Andreas; Kroess, Markus; Dietrich, Johannes; Saczko, Dario; Veigel, Claudia
  作者单位：University of Munich; University of Munich
  摘要：Mitochondrial damage determines cell fate, leading to mitochondrial autophagy or cellular apoptosis in health and disease. The molecular mechanisms and role of the acto-myosin cytoskeleton regulating mitochondrial clearance and membrane remodeling are critical in neurodegenerative disease progression including Alzheimer, but remain unclear. To investigate the potential link between full-length Myosin VI (FL-Myo6) recruitment and exposure of the mitochondria-specific lipid cardiolipin (CL), her...
• Evolution of the essential gene MN1 during the macroevolutionary transition toward patterning the vertebrate hindbrain AI翻译
  作者：Escamilla-Vega, Elio; Seton, Louk W. G.; Kyomen, Stella; Murillo-Rincon, Andrea P.; Petersen, Julian; Tautz, Diethard; Kaucka, Marketa
  作者单位：Max Planck Society; Leipzig University
  摘要：The tight link between brain and skull formation is a fundamental aspect of vertebrate evolution and embryogenesis. Their developmental synchronization is essential for structural and functional integration. The brain and skull shape coevolution is evident along the vertebrate phylogeny; however, the genetic basis underlying their close evolutionary and developmental relationship remains little explored. Here, we reveal the evolution and function of the MN1 gene that was previously found to be...
• Specialized molecular pathways drive the formation of light- scattering assemblies in leucophores AI翻译
  作者：Barzilay, Yuval; Eyal, Zohar; Noy, Yael; Varsano, Neta; Olender, Tsviya; Bera, Sourabh; Lerer-Goldshtein, Tali; Kedmi, Merav; Porat, Ziv; Pinkas, Iddo; Levin-Zaidman, Smadar; Dezorella, Nili; Gur, Dvir
  作者单位：Weizmann Institute of Science; Weizmann Institute of Science; Weizmann Institute of Science
  摘要：Pigmentation plays a vital role in the survival of organisms, supporting functions such as camouflage, communication, and mate attraction. In vertebrates, these functions are mediated by specialized pigment cells known as chromatophores of which, uric acid crystal-forming leucophores remain the least understood, with little known about their molecular mechanisms. A key question in pigment cell biology is whether different crystal chemistries require distinct molecular pathways, or whether simi...
• Microscale technologies for tissue engineering and biology (vol 103, 2480-2487, 2006). AI翻译
  作者：Khademhosseini, Ali; Langer, Robert; Borenstein, Jeffrey; Vacanti, Joseph P.
• The proofreading mechanism of the human leading- strand DNA polymerase ε holoenzyme AI翻译
  作者：Wang, Feng; He, Qing; O'Donnell, Michael E.; Li, Huilin
  作者单位：Van Andel Institute; Rockefeller University; Rockefeller University; Howard Hughes Medical Institute
  摘要：The eukaryotic leading-strand DNA polymerase epsilon(Pol epsilon) is a dual-function enzyme with a proofreading 3 '-5 ' exonuclease (exo) site located 40 & Aring; from the DNA synthesizing pol site. Errors in Pol epsilon proofreading can cause various mutations, including C-to-G trans-versions, the most prevalent mutation in cancers and genetic diseases. Pol epsilon interacts with all three subunits of the PCNA ring to assemble a functional holoenzyme. Despite previous studies on proofreading ...
• Viral and host network analysis of the human cytomegalovirus transcriptome in latency AI翻译
  作者：Collins-McMillen, Donna; Pessoa, Diogo De Oliveira; Zarrella, Kristen; Parkins, Christopher J.; Daily, Michael; McKinzey, David R.; Moorman, Nathaniel J.; Kamil, Jeremy P.; Caposio, Patrizia; Padi, Megha; Goodrum, Felicia D.
  作者单位：University of Arizona; University of Arizona; University of Arizona; Arizona Center Cancer Care; Oregon Health & Science University; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; Louisiana State University System; Louisiana State University Health Sciences Center at Shreveport; University of Arizona; University of Arizona
  摘要：The human cytomegalovirus (HCMV) UL135 and UL138 genes play opposing roles regulating latency and reactivation in CD34+ human progenitor cells. We designed an RNA sequencing study to compare the transcriptional profile of HCMV infection in the presence and absence of these genes using the Tohoku Hospital Pediatrics-1 (THP-1) monocytic cell line model for latency. Relative to primary cell models, THP-1 cells offer the strength of a homogenous population that uniformly silences gene expression a...
• Reversible molecular simulation for training classical and machine-learning force fields AI翻译
  作者：Greener, Joe G.
  作者单位：MRC Laboratory Molecular Biology
  摘要：The next generation of force fields for molecular dynamics will be developed using a wealth of data. Training systematically with experimental data remains a challenge, however, especially for machine-learning potentials. Differentiable molecular simulation calculates gradients of observables with respect to parameters through molecular dynamics trajectories. Here, we improve this approach by explicitly calculating gradients using a reverse-time simulation with effectively constant memory cost...
• CIRCADIAN CLOCK-ASSOCIATED 1 regulates ROS homeostasis and oxidative stress responses (vol 09 , 17129-17134, 2012) AI翻译
  作者：Lai, Alvina Grace; Doherty, Colleen J.; Mueller-Roeber, Bernd; Kay, Steve A.; Schippers, Jos H. M.; Dijkwel, Paul P.