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作者：Song, Hongseon; Bae, Yubin; Kim, Sangin; Deascanis, Dante; Lee, Yujin; Rona, Gergely; Lane, Ethan; Lee, Seo - yeoung; Kim, Su - Jung; Pagano, Michele; Myung, Kyungjae; Kee, Younghoon
作者单位：Daegu Gyeongbuk Institute of Science & Technology (DGIST); Institute for Basic Science - Korea (IBS); State University System of Florida; University of South Florida; New York University; Howard Hughes Medical Institute; New York University; HUN-REN; HUN-REN Research Centre for Natural Sciences; Ulsan National Institute of Science & Technology (UNIST)
摘要：DNA double-strand breaks (DSBs) are harmful lesions and major sources of genomic instability. Studies have suggested that DSBs induce local transcriptional silencing that consequently promotes genomic stability. Several factors have been proposed to actively participate in this process, including Ataxia-telangiectasia mutated (ATM) and Polycomb repressive complex 1 (PRC1). Here, we found that disrupting PRC1 clustering disrupts DSB-induced gene silencing. Interactome analysis of PHC2, a PRC1 s...
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作者：Cook, Shawna R.; Hugen, Sanne; Hayward, Jessica J.; Famula, Thomas R.; Belanger, Janelle M.; McNiel, Elizabeth; Fieten, Hille; Oberbauer, Anita M.; Leegwater, Peter A. J.; Ostrander, Elaine A.; Mandigers, Paul J. J.; Evans, Jacquelyn M.
作者单位：Cornell University; Cornell University; Utrecht University; University of California System; University of California Davis; Tufts University; National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI)
摘要：Gastric cancer ranks as the fifth most common human cancer worldwide and has a poor survival rate and limited treatment options. Despite the high prevalence and mortality rate, the genetic etiology is largely unknown. In dogs, a clinically and histologically similar disease disproportionately affects two breeds, the Belgian Tervuren and Belgian Sheepdog, which develop the intestinal and diffuse tumor subtypes observed in humans. We performed a Bayesian genome-wide association study and selecti...
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作者：Cheng, Holly H.; Roggeveen, James V.; Wang, Huan; Stone, Howard A.; Shi, Zheng; Brangwynne, Clifford P.
作者单位：Princeton University; Rutgers University System; Rutgers University New Brunswick; Princeton University; Princeton University; Princeton University; Howard Hughes Medical Institute
摘要：The nucleolus is a multiphasic biomolecular condensate that facilitates ribosome biogenesis, a complex process involving hundreds of proteins and RNAs. The proper execution of ribosome biogenesis likely depends on the material properties of the nucleolus. However, these material properties remain poorly understood due to the challenges of in vivo measurements. Here, we use micropipette aspiration (MPA) to directly characterize the viscoelasticity and interfacial tensions of nucleoli within tra...
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作者：Lopez-Pereza, Mario; Balasubramanian, Deepak; Lopez, Alicia Campos-; Crist, Cole; Grant, Trudy - Ann; Haro-Moreno, Jose M.; Zaragoza-Solas, Asier; Almagro-Moreno, Salvador
作者单位：Universidad Miguel Hernandez de Elche; St Jude Children's Research Hospital
摘要：The underlying factors that lead to specific strains within a species to emerge as human pathogens remain mostly enigmatic. The diarrheal disease cholera is caused by strains from a phylogenetically confined group within the Vibrio cholerae species, the pandemic cholera group (PCG), making it an ideal model system to tackle this puzzling phenomenon. Comprehensive analyses of over 1,840 V. cholerae genomes, including environmental isolates from this study, reveal that the species consists of el...
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作者：Stiller, Josefin
作者单位：University of Copenhagen
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作者：Xu, Jiuyin; Wu, Yanli; Xu, Youwei; Li, Yang; He, Xinheng; Zhang, Heng; Wang, James Jiqi; Hou, Jingjing; Li, Junrui; Hu, Wen; Wu, Kai; Yuan, Qingning; Wu, Canrong; Xu, H. Eric
作者单位：Chinese Academy of Sciences; Shanghai Institute of Materia Medica, CAS; ShanghaiTech University; Huazhong University of Science & Technology; Huazhong University of Science & Technology; Fudan University; Shanghai Jiao Tong University; Chinese Academy of Sciences; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
摘要：The prostaglandin D2 receptor 1 (DP1), a rhodopsin-like Class A GPCR, orchestrates critical physiological and pathological processes, ranging from sleep regulation to inflammatory responses and cardiovascular function. Despite its therapeutic significance, structural insights into DP1 activation mechanisms have remained elusive. Here, using cryoelectron microscopy (cryo-EM), we determined high-resolution structures of human DP1 in both inactive and active states, with the latter captured in co...
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作者：Lamperis, Sophia M.; Mcmahon, Kaylin M.; Calvert, Andrea E.; Rink, Jonathan S.; Vasan, Karthik; Pandkar, Madhura R.; Crentsil, Eliana U.; Chalmers, Zachary R.; Mcdonald, Natalie R.; Kosmala, Cameron J.; Bonini, Marcelo G.; Matei, Daniela; Gordon, Leo I.; Chandel, Navdeep S.; Thaxton, C. Shad
作者单位：Northwestern University; Feinberg School of Medicine; Northwestern University; Feinberg School of Medicine; Robert H. Lurie Comprehensive Cancer Center; Northwestern University; Feinberg School of Medicine; Ann & Robert H. Lurie Children's Hospital of Chicago; Northwestern University; Feinberg School of Medicine; Northwestern University; Feinberg School of Medicine; Northwestern University; Feinberg School of Medicine; Northwestern University; Feinberg School of Medicine; US Department of Veterans Affairs; Veterans Health Administration (VHA); Jesse Brown VA Medical Center
摘要：Ferroptosis is a cell death mechanism distinguished by its dependence on iron-mediated lipid oxidation. Cancer cells highly resistant to conventional therapies often demonstrate lipid metabolic and redox vulnerabilities that sensitize them to cell death by ferroptosis. These include a unique dependency on the lipid antioxidant selenoenzyme, glutathione peroxidase 4 (GPx4), that acts as a ferroptosis inhibitor. Synthetic high-density lipoprotein-like nanoparticle (HDL NP) targets the high-affin...
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作者：El-Sobky, Mohanad H.; Rijal, Ramesh; Gomer, Richard H.
作者单位：Texas A&M University System; Texas A&M University College Station; University of Southern Mississippi
摘要：The directed movement of eukaryotic cells is critical for processes such as development and immune responses. While much is known about chemoattraction, much less is known about chemorepulsion. The eukaryotic amoeba Dictyostelium discoideum secretes a 60 kDa chemorepellent protein called AprA to cause cells at the edge of a colony to move away from the colony. In addition to AprA, cells secrete a <10 kDa chemorepellent. Here, we show that the <10 kDa chemorepellent is a polymer of phosphates (...
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作者：Munn, Lance L.
作者单位：Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School
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作者：Long, Zhengkun; Northoff, Georg; Fu, Xiaolan
作者单位：Chinese Academy of Sciences; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Shenzhen University; University of Ottawa; Shanghai Jiao Tong University
摘要：Mind wandering attenuates widespread sensory and motor processing, both of which are mediated by phase coherence. However, it remains unclear i) whether mind wandering impacts both sensory input and motor output processing by modulating ii) neural entrainment to external stimuli, as measured by intertrial phase coherence (ITPC), and specifically iii) whether task difficulty with different degrees of attentional demands moderates the impact of mind wandering on phase coherence. Using the though...
