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作者：Kodan, Nishant; Hussaini, Rabeya; Weber, Stephanie C.; Kondev, Jane; Mohapatra, Lishibanya
作者单位：Rochester Institute of Technology; New York University; McGill University; McGill University; Brandeis University
摘要：The nucleolus is a multicomponent structure made of RNA and proteins that serves as the site of ribosome biogenesis within the nucleus. It has been extensively studied as a prototype of a biomolecular condensate whose assembly is driven by phase separation. While the steady-state size of the nucleolus is quantitatively accounted for by the thermodynamics of phase separation, we show that experimental measurements of the assembly dynamics are inconsistent with a simple model of a phase-separati...
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作者：Wen, Wei; Prada, Adriana M.; Turrigiano, Gina G.
作者单位：Brandeis University
摘要：Neocortical circuits use synaptic and intrinsic forms of homeostatic plasticity to stabilize key features of network activity, but whether these different homeostatic mechanisms act redundantly or can be independently recruited to stabilize different network features is unknown. Here, we used pharmacological and genetic perturbations both in vitro and in vivo to determine whether synaptic scaling and intrinsic homeostatic plasticity (IHP) are arranged and recruited in a hierarchical or modular...
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作者：Clark, Cory J.; Jussim, Lee; Frey, Komi; Stevens, Sean T.; al-Gharbi, Musa; Aquino, Karl; Bailey, J. Michael; Barbaro, Nicole; Baumeister, Roy F.; Bleske-Rechek, April; Buss, David; Ceci, Stephen; Giudice, Marco Del; Ditto, Peter H.; Forgas, Joseph P.; Geary, David C.; Geher, Glenn; Haider, Sarah; Honeycutt, Nathan; Joshi, Hrishikesh; Krylov, Anna I.; Loftus, Elizabeth; Loury, Glenn; Lu, Louise; Macy, Michael; Martin, Chris C.; McWhorter, John; Miller, Geoffrey; Paresky, Pamela; Pinker, Steven; Reilly, Wilfred; Salmon, Catherine; Stewart-Williams, Steve; Tetlock, Philip E.; Williams, Wendy M.; Wilson, Anne E.; Winegard, Bo M.; Yancey, George; von Hippel, William
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作者：Ornes, Stephen
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作者：Siqueira-Batista, Rodrigo; Gomez, Felipe
作者单位：Universidade Federal de Vicosa; Consejo Superior de Investigaciones Cientificas (CSIC)
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作者：Whetsel, Charles W.; Levine, Joel S.; Hoffman, Stephen J.; Antonsen, Erik L.
作者单位：National Aeronautics & Space Administration (NASA); NASA Jet Propulsion Laboratory (JPL); California Institute of Technology; Aerospace Corporation - USA; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital
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作者：Kalutskii, Maksim; Grubmueller, Helmut; Volkov, Vladimir A.; Igaev, Maxim
作者单位：University of London; Queen Mary University London; University of Dundee
摘要：Microtubules are dynamic cytoskeletal polymers that add and lose tubulin dimers at their ends. Microtubule growth, shortening, and transitions between them are linked to GTP hydrolysis. Recent evidence suggests that flexible tubulin protofilaments at microtubule ends adopt a variety of shapes, complicating structural analysis using conventional techniques. Therefore, the link between GTP hydrolysis, protofilament structure and microtubule polymerization state is poorly understood. Here, we inv...
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作者：He, Biao; Li, Meilin; Guo, Shuai; Zhu, Feng; Jiao, Zhiwei; Li, Jianyong; Tan, Nie; Jiao, Shiming; Liu, Taiping; Zhang, Jian; Fan, Yongling; Gao, Yuanli; Zhou, Taoli; Li, Jian; Huang, Wei; Jiang, Lubin; Lin, Zurui; Wang, Sibao; Xu, Wenyue
作者单位：Army Medical University; Xiamen University; Chinese Academy of Sciences; Shanghai Institute of Immunity and Infection, CAS; Pasteur Network; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Center for Excellence in Molecular Plant Sciences, CAS
摘要：Host-derived factors ingested during mosquito blood feeding are poorly understood modulators of malaria transmission. Here, we demonstrated that host complement C3, acquired by mosquitoes during Plasmodium infection, significantly enhanced rodent malaria infection in laboratory-reared mosquitoes. This effect was recapitulated in field-caught Anopheles sinensis mosquitoes, confirming its relevance to malaria transmission in a more natural setting. Moreover, host-derived C3 significantly reduced...
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作者：Moser, Tobias; Roos, Lennart
作者单位：University of Gottingen; UNIVERSITY GOTTINGEN HOSPITAL; University of Gottingen; University of Gottingen; UNIVERSITY GOTTINGEN HOSPITAL; University of Gottingen; UNIVERSITY GOTTINGEN HOSPITAL
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作者：Kuo, Pallas; Tock, Andrew J.; Liu, Xuexia; Topp, Stephanie D.; Zhong, Zhenhui; Henderson, Ian R.; Lambing, Christophe
作者单位：UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); Rothamsted Research; University of Cambridge; Sichuan University
摘要：In eukaryotic genomes, DNA is packaged into nucleosomes to form chromatin. The incorporation of canonical or variant histones into nucleosomes confers different properties and influences chromatin structure to regulate cellular processes, including recombination. During meiosis, DNA double-strand breaks (DSBs) are formed and repaired as interhomolog crossovers. Nucleosome occupancy is generally associated with low crossover frequency, but it remains unclear which histone variants are involved ...
