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作者：Song, Shuang; Benonisdottir, Stefania; Liu, Jun S.; Kong, Augustine
作者单位：Harvard University; Harvard T.H. Chan School of Public Health; University of Oxford; University of Iceland; Harvard University
摘要：It is increasingly recognized that participation bias can pose problems for genetic studies. Recently, to overcome the challenge that genetic information of nonparticipants is unavailable, it is shown that by comparing the IBD (identity by descent) shared and not-shared segments between participating relative pairs, one can estimate the genetic component underlying participation. That, however, does not directly address how to adjust estimates of heritability and genetic correlation for phenot...
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作者：Foo, Sherman; Caspy, Ido; Cezanne, Alice; Bharat, Tanmay A. M.; Baum, Buzz
作者单位：MRC Laboratory Molecular Biology; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); UK Research & Innovation (UKRI); Medical Research Council UK (MRC); MRC Laboratory Molecular Biology
摘要：The surface layer or S- layer is a two- dimensional lattice of proteins that coats a wide are thought to play an important role in chemically and physically insulating cells from the external environment. Here, we show that the integrity of the S- layer in Sulfolobus acidocaldarius is maintained as cells grow via a process of self- assembly as SlaA monomers fill gaps in the lattice. Although this lattice which is physically tethered to the membrane might be expected to hinder cell division, we...
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作者：Vosbigian, Kaylee A.; Wright, Sarah J.; Steiert, Brianna P.; Rosche, Kristin L.; Fisk, Elis A.; Ramirez-Zepp, Elisabeth; Park, Jason M.; Shelden, Eric A.; Shaw, Dana K.
作者单位：Washington State University; Washington State University; University of Wisconsin System; University of Wisconsin Madison
摘要：How tick-borne pathogens interact with their hosts has been primarily studied in vertebrates where disease is observed. Comparatively less is known about pathogen interactions within the tick. Here, we report that Ixodes scapularis ticks infected with either Anaplasma phagocytophilum (causative agent of anaplasmosis) or Borrelia burgdorferi (causative agent of Lyme disease) show activation of the ATF6 branch of the unfolded protein response (UPR). Disabling ATF6 functionally restricts pathogen...
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作者：Loytynoja, Ari; Pohjoismaki, Jaakko; Valtonen, Mia; Laakkonen, Juha; Morita, Wataru; Kunnasranta, Mervi; Vainola, Risto; Olsen, Morten Tange; Auvinen, Petri; Jernvall, Jukka
作者单位：University of Helsinki; University of Eastern Finland; Natural Resources Institute Finland (Luke); University of Helsinki; National Museum of Nature and Science; Natural Resources Institute Finland (Luke); University of Helsinki; University of Copenhagen; University of Helsinki; University of Helsinki
摘要：Isolated populations of postglacial relicts are known from many regions and are typically found on mountains for terrestrial species and in lakes for aquatic species. Among the few aquatic mammalian relicts, the Saimaa ringed seal (Pusa hispida saimensis) has been landlocked in Lake Saimaa, Finland, for the last 10,000 y. Saimaa ringed seals show genetic, behavioral, and morphological differences from the other ringed seal subspecies, but the extent these differences stem from the end of the l...
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作者：Oppedisano, Anthony; Bailey, Melanie L.; Kumar, Arun; O' Neil, Nigel J.; Stirling, Peter C.; Hieter, Philip
作者单位：University of British Columbia; British Columbia Cancer Agency
摘要：Protein structure-function relationships are critical for understanding molecular mechanisms and the impacts of genetic variation. Mutational scanning approaches can deliver scalable analysis, usually through the study of loss-of-function variants. Rarer dominant negative and gain-of-function variants can be more information rich, as they retain a stable proteoform and can be used to dissect molecular function while retaining biological context. Dominant variant proteoforms can still engage su...
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作者：Sonawane, Chinmay; Xu, Maya; Ward, Natalie; Lac, Ariella Chichilnisky du; Kamets, Bohdan; Dirzo, Rodolfo
作者单位：Stanford University; Stanford University; Stanford University
摘要：Vertebrate scavengers play a critical role in ecosystem functioning worldwide. Through the cascading effects of their ecological role, scavengers can also alleviate the burden of zoonotic diseases on people. This importance to human health fuels a growing need to understand how vertebrate scavengers and their ecosystem services are faring globally in the Anthropocene. We reviewed the conservation status of 1,376 vertebrate scavenging species and examined the implications for human health. We u...
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作者：Barrera, Francisco N.
作者单位：University of Tennessee System; University of Tennessee Knoxville
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作者：Borovska, Petra; de Haas, Benjamin
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作者：Garcia, Julian; Traulsen, Arne
作者单位：Monash University; Max Planck Society
摘要：Evolutionary game theory (EGT) has been pivotal in the study of cooperation, offering formal models that account for how cooperation may arise in groups of selfish, but simple agents. This is done by inspecting the complex dynamics arising from simple interactions between a few strategies in a large population. As such, the strategies at stake are typically hand-picked by the modeler, resulting in a system with many more individuals in the population than strategies available to them. In the p...
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作者：Liu, Xingyu; Yi, Li; Lin, Zongtao; Chen, Siyu; Wang, Shunyang; Sheng, Ying; Lebrilla, Carlito B.; Garcia, Benjamin A.; Xie, Yixuan
作者单位：Fudan University; Fudan University; Washington University (WUSTL); University of California System; University of California Davis; University of California System; University of California Davis
摘要：Protein-protein interactions (PPIs) are crucial for comprehending the molecular mechanisms and signaling pathways underlying diverse biological processes and disease progression. However, investigating PPIs involving membrane proteins is challenging due to the complexity and heterogeneity of glycosylation. To tackle this challenge, we developed an approach termed glycan-dependent affinity purification coupled with mass spectrometry (GAP-MS), specifically designed to characterize changes in gly...
