25期

最新文章

• Tumor-promoting UBR4 coordinates impaired mitophagy-associated senescence and lung adenocarcinoma pathogenesis AI翻译
  作者：Jeong, Dawon; Park, Seo Hyeong; Kim, Jiwon; Kim, Hyeyoon; Jang, Yejin; Koh, Jaemoon; Jeon, Yoon Kyung; Tasaki, Takafumi; Kwon, Yong Tae; Han, Dohyun; Cho, Sung-Yup; Lee, Min Jae
  作者单位：Seoul National University (SNU); Seoul National University (SNU); Seoul National University (SNU); Seoul National University Hospital; Seoul National University (SNU); Seoul National University Hospital; United States Department of Energy (DOE); Pacific Northwest National Laboratory; Seoul National University (SNU); Kanazawa Medical University; University of California System; University of California Los Angeles; Seoul National University (SNU)
  摘要：Cellular senescence, an irreversible cell cycle arrest, plays a pivotal role in development, aging, and tumor suppression. However, the fundamental pathway coordinating senescence and neoplastic transformation remains unclear. Here, we describe the tumorigenic involvement of ubiquitin protein ligase E3 component n-recognin 4 (UBR4), an E3 ubiquitin ligase of the N-degron pathway, in lung adenocarcinoma (LUAD). Public genome databases revealed high UBR4 expression in LUAD patients, associated w...
• Heightened interest in the human X and Y chromosomes AI翻译
  作者：Lawson, Ann Marie; Mueller, Jacob L.
  作者单位：University of Michigan System; University of Michigan
• A norm about harvest division is maintained by a desire to follow tradition, not by social policing AI翻译
  作者：Yan, Minhua; Li, Zhizhong; Li, Yuanmei; Boyd, Robert; Mathew, Sarah; Weber, Elke
  作者单位：Universite de Toulouse; Universite Toulouse 1 Capitole; Toulouse School of Economics; Max Planck Society; Arizona State University; Arizona State University-Tempe; Arizona State University; Arizona State University-Tempe
  摘要：Determining how people behave in contexts governed by social norms can clarify both how norms influence human behavior and how norms evolve. We examined cooperative farming harvest division among the Derung, a Tibeto-Burman-speaking horticultural society in southwestern China. In the village of Dizhengdang, the norm dictates that cofarming harvests should be divided equally among participating households. This contrasts with an alternative norm followed in some other Derung villages that holds...
• The oncogene SLC35F2 is a high- specificity transporter for the micronutrients queuine and queuosine AI翻译
  作者：Burtnyak, Lyubomyr; Yuan, Yifeng; Stojek, Erwina; Pan, Xiaobei; Gunaratne, Lankani; Silveira, Gabriel; Fergus, Claire; Martinelli, Maria; Reed, Colbie J.; Fernandez, Jessie; Patel, Bhargesh Indravadan; Marquez, Isaac; Ehrenhofer-Murray, Ann E.; Swairjo, Manal A.; Alfonzo, Juan D.; Green, Brian D.; Kelly, Vincent P.; de Crecy-Lagard, Valerie
  作者单位：Trinity College Dublin; State University System of Florida; University of Florida; Queens University Belfast; Brown University; Brown University; University System of Ohio; Ohio State University; Humboldt University of Berlin; California State University System; San Diego State University; State University System of Florida; University of Florida
  摘要：The nucleobase queuine (q) and its nucleoside queuosine (Q) are micronutrients derived from bacteria that are acquired from the gut microbiome and/or diet in humans. Following cellular uptake, Qis incorporated at the wobble base (position 34) of tRNAs that decode histidine, tyrosine, aspartate, and asparagine codons, which is important for efficient translation. Early studies suggested that cytosolic uptake of queuine is mediated by a selective transporter that is regulated by mitogenic signal...
• Global universal scaling and ultrasmall parameterization in machine-learning interatomic potentials with superlinearity AI翻译
  作者：Hu, Yanxiao; Sheng, Ye; Huang, Jing; Xu, Xiaoxin; Yang, Yuyan; Zhang, Mingqiang; Wu, Yabei; Ye, Caichao; Yang, Jiong; Zhang, Wenqing
  作者单位：Southern University of Science & Technology; Southern University of Science & Technology; Shanghai University; Southern University of Science & Technology; Southern University of Science & Technology
  摘要：Using machine learning (ML) to construct interatomic interactions and thus potential energy surface (PES) has become a common strategy for materials design and simulations. However, those current models of machine-learning interatomic potential (MLIP) consider no relevant physical constraints or global scaling and thus may owe intrinsic outof-domain difficulty which underlies the challenges of model generalizability and physical scalability. Here, by incorporating the global universal scaling ...
• European mammal turnover driven by a global rapid warming event preceding the Paleocene-Eocene Thermal Maximum AI翻译
  作者：Tabuce, Rodolphe; Marandat, Bernard; Adnet, Sylvain; Gernelle, Killian; Girard, Flavia; Marivaux, Laurent; Sole, Floreal; Schnyder, Johann; Steurbaut, Etienne; Storme, Jean-Yves; Vianey-Liaud, Monique; Yans, Johan
  作者单位：Centre National de la Recherche Scientifique (CNRS); Institut de Recherche pour le Developpement (IRD); Universite de Montpellier; Universite PSL; Ecole Pratique des Hautes Etudes (EPHE); Universite de Montpellier; Centre National de la Recherche Scientifique (CNRS); Royal Belgian Institute of Natural Sciences; Sorbonne Universite; Centre National de la Recherche Scientifique (CNRS); University of Namur
  摘要：A brief global warming event known as the Pre-Onset Excursion (POE) occurred just before the Paleocene-Eocene Thermal Maximum (PETM, 56 Mya). The deconvolution of the evolutionary consequences of these two hyperthermal events is puzzling because of their close temporal proximity and the lack of comprehensive, well-calibrated paleontological records, especially in terrestrial environments. As a consequence, the impact of the POE on mammalian evolution and its role in shaping PETM faunas remains...
• Beyond additive genetic effects: Explaining family resemblance in school performance across millions of pairs of Norwegian relatives AI翻译
  作者：Eftedal, Nikolai Haahjem; Eilertsen, Espen Moen; Sunde, Hans Fredrik; Kleppestoc, Thomas Haarklau; Ystrom, Eivind; Czajkowski, Nikolai Olavi
  作者单位：University of Oslo; Norwegian Institute of Public Health (NIPH); Norwegian University of Science & Technology (NTNU); Norwegian Institute of Public Health (NIPH)
  摘要：We investigate the hypothesis that family resemblance on school performance can be fully explained by additive genetic effects and assortative mating. Our sample consists of all schoolchildren who took Norwegian national standardized tests between 2007 and 2019 (N = 936,708). These tests measure aptitude in math and reading comprehension, and are taken the years children turn 10, 13, and 14 y old. We identify millions of pairs of relatives within our sample (82 different kinds, in total), incl...
• Longitudinal sequencing reveals polygenic and epistatic nature of genomic response to selection AI翻译
  作者：Forsberg, Simon K. G.; Melo, Diogo; Wolf, Scott W.; Grenier, Jennifer K.; Tang, Minjia; Henry, Lucas P.; Pallares, Luisa F.; Clark, Andrew G.; Ayroles, Julien F.
  作者单位：Princeton University; Princeton University; Cornell University; Eberhard Karls University of Tubingen; Max Planck Society
  摘要：Evolutionary adaptation to new environments likely results from a combination of selective sweeps and polygenic shifts, depending on the genetic architecture of traits under selection. While selective sweeps have been widely studied, polygenic responses are thought to be more prevalent but remain challenging to quantify. The infinitesimal model makes explicit the hypothesis about the dynamics of changes in allele frequencies under selection, where only allelic effect sizes, frequencies, linkag...
• Cryo- EM structures of GnRHR: Foundations for next- generation therapeutics AI翻译
  作者：Shen, Shiyi; He, Xinheng; Liu, Heng; Hu, Wen; Xu, H. Eric; Duan, Jia
  作者单位：Chinese Academy of Sciences; Shanghai Institute of Materia Medica, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; ShanghaiTech University; Chinese Academy of Sciences; Shanghai Institute of Materia Medica, CAS
  摘要：Gonadotropin-releasing hormone receptor (GnRHR) is critical for reproductive health and a key therapeutic target for endocrine disorders and hormone-responsive cancers. Using high-resolution cryoelectron microscopy, we determined the structures of Sus scrofa and Xenopus laevis GnRHRs bound to mammal GnRH, uncovering conserved and species-specific mechanisms of receptor activation and G protein coupling. The conserved U- shaped GnRH conformation mediates high-affinity binding through key intera...
• Decreased mitochondrial activity in the demyelinating cerebellum of progressive multiple sclerosis and chronic EAE contributes to Purkinje cell loss AI翻译
  作者：Atkinson, Kelley C.; Desfor, Shane; Feri, Micah; Sekyi, Maria T.; Osunde, Marvellous; Sriram, Sandhya; Noori, Saima; Rincon, Wendy; Bello, Britany; Tiwari-Woodruff, Seema K.
  作者单位：University of California System; University of California Riverside
  摘要：In multiple sclerosis (MS), cerebellar gray matter atrophy, white matter demyelination, and Purkinje cell (PC) loss have been linked to tremors, impaired motor control, and loss of coordination. Similar pathologies have been observed in the mouse model of MS, experimental autoimmune encephalomyelitis (EAE). This study hypothesized that inflammatory demyelination of the cerebellum alters overall mitochondrial function and is a contributor to axon degeneration and PC loss. Postmortem cerebellar ...