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作者：Maher, Christina; Tortolero, Lea; Jun, Soyeon; Cummins, Daniel D.; Saad, Adam; Young, James; Martinez, Lizbeth Nunez; Schulman, Zachary; Marcuse, Lara; Waters, Allison; Mayberg, Helen S.; Davidson, Richard J.; Panov, Fedor; Saez, Ignacio
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作者：Meng, Yao; McAvoy, Alex; Li, Aming
作者单位：Peking University; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; Peking University
摘要：Collective cooperation maintains the function of many natural and social systems, making understanding the evolution of cooperation a central question of modern science. Although human interactions involve complex contact networks, current explorations are limited to static networks, where social ties are permanent and do not change over time. In reality, human activities often involve temporal interactions, where links are impermanent, and understanding the evolution of cooperation on such te...
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作者：Zhang, Wenyi; Shichijo, Takafumi; Chen, Xueda; Watanabe, Miho; Nosaka, Kisato; Matsuoka, Masao; Yasunaga, Jun-ichirou
作者单位：Kumamoto University
摘要：The HTLV-1 bZIP factor (HBZ) gene, which is the only viral gene conserved and consistently expressed in all adult T-cell leukemia-lymphoma (ATL) cases, is critical for ATL oncogenesis. Although HBZ protein is found in both the nucleus and the cytoplasm, the dynamics of HBZ protein localization and its contribution to oncogenesis have not been fully elucidated. In this study, we analyzed the subcellular expression pattern of HBZ in primary HTLV-1-infected T cells from asymptomatic carriers and ...
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作者：Boonman, Coline C. F.; Hoeks, Selwyn; Serra-Diaz, Josep M.; Guo, Wen-Yong; Enquist, Brian J.; Maitner, Brian; Merow, Cory; Svenning, Jens-Christian
作者单位：Aarhus University; Wageningen University & Research; Radboud University Nijmegen; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Institut Botanic de Barcelona (ICUB); INRAE; AgroParisTech; Universite de Lorraine; East China Normal University; University of Arizona; The Santa Fe Institute; State University System of Florida; University of South Florida; University of Connecticut; University of Connecticut
摘要：Tree species worldwide face increasing exposure to unprecedented macroclimatic conditions due to anthropogenic climate change, which may trigger biome shifts and ecosystem disruptions. We quantified climate change exposure-shifts to species' currently unoccupied climate zones-for 32,089 tree species globally by 2100, assessing both species-level and local tree diversity risks. On average, 69% of species are predicted experience macroclimatic shifts in at least 10% of their range, while 14% fac...
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作者：Mandala, Venkata Shiva; Fu, Ziao; Mackinnon, Roderick
作者单位：Rockefeller University; Howard Hughes Medical Institute; Rockefeller University; Washington University (WUSTL)
摘要：Motivated by recent data pointing to the existence of homo- oligomeric assemblies of membrane proteins called higher- order transient structures, and their apparent role in connecting components of membrane signal pathways, we examine here by cryoelectron microscopy some of the protein-protein interactions that occur in cluster formation. Metabotropic glutamate receptors and HCN ion channels inside clusters contact their neighbors through structured extracellular and intracellular domains, res...
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作者：Sosa, Enrique; Wamaitha, Sissy E.; Hsu, Fei-man; Lara, Mary Jasmine D.; Oyama, Kiana; Custer, Maggie; Murphy, Melinda; Hennebold, Jon D.; Hwang, Young Sun; Clark, Amander T.
作者单位：University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; Oregon Health & Science University; Oregon National Primate Research Center; Oregon Health & Science University
摘要：The formation of bilateral testes in animals is critical for puberty, reproductive capacity, and testosterone production across the life course. In humans, testis development begins in embryonic life in the first trimester, with considerable effort focused on the cell and developmental events associated with testis cell specification, leaving limited knowledge on testicular organogenesis during the second and third trimesters. To fill this knowledge gap, we evaluated testicular cell maturation...
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作者：Wang, Shao-Zheng; Wang, Shou-Bo; Tao, Zhi-Jin; Xia, Tian; Lu, Zheng-Tian
作者单位：Chinese Academy of Sciences; University of Science & Technology of China, CAS; Hefei National Laboratory; Chinese Academy of Sciences; University of Science & Technology of China, CAS
摘要：The response of an atom to external electric and magnetic fields can reveal fundamental atomic properties. It has long been verified that, in a static magnetic field, those atomic energy levels with hyperfine interactions shift according to the Breit-Rabi formula, which introduces nonlinear dependence on the magnetic field. On the other hand, the corresponding Breit-Rabi dependence on a static electric field has not been observed before due to a combination of experimental challenges. Here, we...
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作者：Lim, Jina; Jung, Hae Deok; Park, Soo Young; Jeon, Moonhyeon; Kim, Da Sol; Cho, Ryeongeun; Han, Dohyun; Ryu, Han Suk; Kim, Yoosik; Kim, Hyun Uk
作者单位：Korea Advanced Institute of Science & Technology (KAIST); Seoul National University (SNU); Seoul National University Hospital; Seoul National University (SNU); Seoul National University Hospital; Seoul National University (SNU); Seoul National University Hospital; Seoul National University (SNU); Seoul National University (SNU); Korea Advanced Institute of Science & Technology (KAIST); Korea Advanced Institute of Science & Technology (KAIST); Korea Advanced Institute of Science & Technology (KAIST); Korea Advanced Institute of Science & Technology (KAIST)
摘要：Anticancer chemotherapy is an essential part of cancer treatment, but the emergence of resistance remains a major hurdle. Metabolic reprogramming is a notable phenotype associated with the acquisition of drug resistance. Here, we develop a computational framework that predicts metabolic gene targets capable of reverting the metabolic state of drug-resistant cells to that of drug-sensitive parental cells, thereby sensitizing the resistant cells. The computational framework performs single-gene ...
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作者：Wang, Haozhe; Zaini, Aidil; Cardwell, Bailey; Rowe, Matthew C.; Butler, Alana; Wong, Connie H. Y.; Poole, Daniel P.; Marsland, Benjamin; Bornstein, Joel C.; Harris, Nicola L.
作者单位：Monash University; Monash University; Monash University; University of Melbourne
摘要：Gastrointestinal (GI) neuroimmune interactions are crucial sensors and regulators of tissue homeostasis. Most enteric neurons reside within the myenteric plexus of the enteric nervous system in the muscular region, forming a structure called the muscularis externa. Despite established interactions between muscularis macrophages and neurons, the presence and function of other immune cell types remains poorly characterized. Here, we mapped the muscularis immune cell landscape, revealing that div...
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作者：Wang, Mingyi; Vladimirsky, Alexander; Giometto, Andrea
作者单位：Cornell University; Cornell University; Cornell University
摘要：Antagonistic interactions are critical determinants of microbial community stability and composition, offering host benefits such as pathogen protection and providing avenues for antimicrobial control. While the ability to eliminate competitors confers an advantage to antagonistic microbes, it often incurs a fitness cost. Consequently, many microbes only produce toxins or engage in antagonistic behavior in response to specific cues like quorum sensing molecules or environmental stress. In labo...
