26期

最新文章

• Crystal structure and catalytic mechanism of drimenol synthase, an unusual bifunctional terpene cyclase-phosphatase AI翻译
  作者：Osika, Kristin R.; Gaynes, Matthew N.; Christianson, David W.
  作者单位：University of Pennsylvania
  摘要：Drimenol synthase from Aquimarina spongiae (AsDMS) is a highly unusual chimera that integrates two distinct, sequential isoprenoid processing activities within a single polypeptide chain. AsDMS catalyzes the class II cyclization of farnesyl diphosphate (FPP) to form drimenyl diphosphate, which then undergoes enzyme- catalyzed hydrolysis to yield drimenol, a bioactive sesquiterpene alcohol with antifungal and anticancer properties. Here, we report the X- ray crystal structures of AsDMS and its ...
• High tree diversity exposed to unprecedented macroclimatic conditions even under minimal anthropogenic climate change AI翻译
  作者：Boonman, Coline C. F.; Hoeks, Selwyn; Serra-Diaz, Josep M.; Guo, Wen-Yong; Enquist, Brian J.; Maitner, Brian; Merow, Cory; Svenning, Jens-Christian
  作者单位：Aarhus University; Wageningen University & Research; Radboud University Nijmegen; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Institut Botanic de Barcelona (ICUB); Universite de Lorraine; AgroParisTech; INRAE; East China Normal University; University of Arizona; The Santa Fe Institute; State University System of Florida; University of South Florida; University of Connecticut; University of Connecticut
  摘要：Tree species worldwide face increasing exposure to unprecedented macroclimatic conditions due to anthropogenic climate change, which may trigger biome shifts and ecosystem disruptions. We quantified climate change exposure-shifts to species' currently unoccupied climate zones-for 32,089 tree species globally by 2100, assessing both species-level and local tree diversity risks. On average, 69% of species are predicted experience macroclimatic shifts in at least 10% of their range, while 14% fac...
• Molecular contacts in self- assembling clusters of membrane proteins AI翻译
  作者：Mandala, Venkata Shiva; Fu, Ziao; Mackinnon, Roderick
  作者单位：Rockefeller University; Rockefeller University; Howard Hughes Medical Institute; Washington University (WUSTL)
  摘要：Motivated by recent data pointing to the existence of homo- oligomeric assemblies of membrane proteins called higher- order transient structures, and their apparent role in connecting components of membrane signal pathways, we examine here by cryoelectron microscopy some of the protein-protein interactions that occur in cluster formation. Metabotropic glutamate receptors and HCN ion channels inside clusters contact their neighbors through structured extracellular and intracellular domains, res...
• Testicular somatic and germ cell maturation during rhesus macaque development AI翻译
  作者：Sosa, Enrique; Wamaitha, Sissy E.; Hsu, Fei-man; Lara, Mary Jasmine D.; Oyama, Kiana; Custer, Maggie; Murphy, Melinda; Hennebold, Jon D.; Hwang, Young Sun; Clark, Amander T.
  作者单位：University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; Oregon Health & Science University; Oregon National Primate Research Center; Oregon Health & Science University
  摘要：The formation of bilateral testes in animals is critical for puberty, reproductive capacity, and testosterone production across the life course. In humans, testis development begins in embryonic life in the first trimester, with considerable effort focused on the cell and developmental events associated with testis cell specification, leaving limited knowledge on testicular organogenesis during the second and third trimesters. To fill this knowledge gap, we evaluated testicular cell maturation...
• Observation of the electric Breit-Rabi effect AI翻译
  作者：Wang, Shao-Zheng; Wang, Shou-Bo; Tao, Zhi-Jin; Xia, Tian; Lu, Zheng-Tian
  作者单位：Chinese Academy of Sciences; University of Science & Technology of China, CAS; Hefei National Laboratory; Chinese Academy of Sciences; University of Science & Technology of China, CAS
  摘要：The response of an atom to external electric and magnetic fields can reveal fundamental atomic properties. It has long been verified that, in a static magnetic field, those atomic energy levels with hyperfine interactions shift according to the Breit-Rabi formula, which introduces nonlinear dependence on the magnetic field. On the other hand, the corresponding Breit-Rabi dependence on a static electric field has not been observed before due to a combination of experimental challenges. Here, we...
• Repeated occurrences of marine anoxia under high atmospheric O2 and icehouse conditions AI翻译
  作者：Chen, Jitao; Li, Shihan; Zhang, Shuang; Isson, Terry; Dahl, Tais W.; Planavsky, Noah J.; Zhang, Feifei; Wang, Xiang-dong; Shen, Shu-zhong; Montanez, Isabel P.
  作者单位：Chinese Academy of Sciences; Nanjing Institute of Geology & Paleontology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Texas A&M University System; Texas A&M University College Station; University of Waikato; University of Copenhagen; Yale University; Nanjing University; Nanjing University; University of California System; University of California Davis; University of California System; University of California Davis
  摘要：The Late Paleozoic Ice Age (similar to 340 to 260 Ma) occurred under peak atmospheric O-2 (1.2 to 1.7 PIAL, pre-industrial atmospheric levels) for Earth history and CO2 concentrations comparable to those of the preindustrial to that anticipated for our near future. The evolution of the marine redox landscape under these conditions remains largely unexplored, reflecting that oceanic anoxia has long been considered characteristic of carbon cycle perturbation during greenhouse times. Despite elev...
• Bone morphogenetic protein-9 controls pulmonary vascular growth and remodeling AI翻译
  作者：Berrebeh, Nihel; Mbouamboua, Yvon; Thuillet, Raphael; Ottaviani, Mina; Robert, Fabien; Chelgham, Mustapha Kamel; Magnone, Virginie; Desroches-Castan, Agnes; Ricard, Nicolas; Anegon, Ignacio; Remy, Severine; Schermuly, Ralph Theo; Lebrigand, Kevin; Kojonazarov, Baktybek; Savale, Laurent; Humbert, Marc; Bailly, Sabine; Barbry, Pascal; Tu, Ly; Guignabert, Christophe
  作者单位：Universite Paris Saclay; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Saclay; Centre National de la Recherche Scientifique (CNRS); Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Cote d'Azur; CEA; Institut National de la Sante et de la Recherche Medicale (Inserm); Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); Nantes Universite; Institut National de la Sante et de la Recherche Medicale (Inserm); Justus Liebig University Giessen; Assistance Publique Hopitaux Paris (APHP); Universite Paris Saclay; Hopital Universitaire Antoine-Beclere - APHP; Hopital Universitaire Bicetre - APHP; Universite Cote d'Azur
  摘要：Pulmonary arterial hypertension (PAH) and hereditary hemorrhagic telangiectasia (HHT) are two distinct vascular diseases linked to impaired signaling through bone morphogenetic protein (BMP) receptor complexes in endothelial cells. Although BMP-9 plays a central role in activating this pathway by binding to ALK1 and BMPR-II, its precise function in the pulmonary microvasculature has remained unclear. In this study, we demonstrate a role for BMP-9 in regulating pulmonary vascular architecture a...
• The evolution of robustness and fragility during long- term bacterial adaptation (vol 122, e2501901122, 2025) AI翻译
  作者：Chihoub, Doha; Pintard, Coralie; Lenski, Richard E.; Tenaillon, Olivier; Couce, Alejandro
• A bioinspired and degradable riboflavin- containing polypeptide as a sustainable material for energy storage AI翻译
  作者：Li, Shih - Guo; Mohanty, Khirabdhi T.; Easley, Alexandra D.; Rezenom, Yohannes H.; Lim, Soon - Mi; Gillett, Leyla P.; Naquin, Stone D.; Tran, David K.; Nguyen, Tan P.; Lutkenhaus, Jodie L.; Wooley, Karen L.
  作者单位：Texas A&M University System; Texas A&M University College Station; Texas A&M University System; Texas A&M University College Station; Texas A&M University System; Texas A&M University College Station
  摘要：Inspired by Nature, we present a polypeptide-based organic redox-active material constructed from renewable feedstocks, L-glutamic acid (an amino acid) and riboflavin (vitamin B2), to address challenges with start-to-end-of-life management in energy storage systems (ESSs). The amino acid was utilized to establish a degradable polymer backbone, along which many copies of riboflavin were incorporated to serve as the redox-active pendant groups that enabled energy storage. The overall synthesis i...
• PIK3CA gain-of-function mutation in Schwann cells leads to severe neuropathy and aerobic glycolysis through a non-cell autonomous effect AI翻译
  作者：Venot, Quitterie; Firpion, Marina; Ladraa, Sophia; Bayard, Charles; Magassa, Sato; Di Guardo, Roberta; Fraissenon, Antoine; Hoguin, Clement; Protic, Sanela; Morin, Gabriel; Mayeux, Franck; Gourdon, Genevieve; Fraitag, Sylvie; Balducci, Estelle; Kaltenbach, Sophie; Villarese, Patrick; Asnafi, Vahid; Viel, Thomas; Autret, Gwennhael; Tavitian, Bertrand; Goudin, Nicolas; Guibaud, Laurent; Bolino, Alessandra; Canaud, Guillaume
  作者单位：Universite Paris Cite; Universite Paris Cite; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite; Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Necker-Enfants Malades - APHP; Vita-Salute San Raffaele University; IRCCS Ospedale San Raffaele; CHU Lyon; Institut National des Sciences Appliquees de Lyon - INSA Lyon; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute for Engineering & Systems Sciences (INSIS); CHU de St Etienne; Institut National de la Sante et de la Recherche Medicale (Inserm); Sorbonne Universite; Universite Paris Cite; Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Necker-Enfants Malades - APHP; Universite Paris Cite; Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Necker-Enfants Malades - APHP; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite; Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); Universite Paris Cite; CNRS - National Institute for Biology (INSB); Vita-Salute San Raffaele University
  摘要：PIK3CA-related disorders are rare genetic disorders due to somatic gain-of-function mutations in PIK3CA during embryonic development, a pathway involved in cell growth, proliferation, and metabolism. Accumulating evidence from patients with PIK3CA-related disorders indicates that peripheral nerves are frequently affected, leading to severe neurological symptoms. However, the exact underlying mechanism of these disorders remains unclear. To address this, we developed a mouse model with a PIK3CA...