26期

最新文章

• S-adenosylmethionine metabolism buffering is regulated by a decrease in glycine N-methyltransferase via the nuclear ubiquitin-proteasome system AI翻译
  作者：Kashio, Soshiro; Miura, Masayuki
  作者单位：University of Tokyo; Tohoku University; National Institutes of Natural Sciences (NINS) - Japan; National Institute for Basic Biology (NIBB)
  摘要：Metabolic homeostasis is essential for survival; however, many studies have focused on the fluctuations of these factors. Furthermore, while metabolic homeostasis depends on the balance between the production and consumption of metabolites, there have been limited investigations into the mechanisms regulating their consumption. S-adenosylmethionine (SAM) metabolism has diverse functions, including methylation, polyamine biosynthesis, and transsulfuration, making its regulation and control cruc...
• Genetic contributions to brain criticality and its relationship with human cognitive functions AI翻译
  作者：Xin, Yumeng; Cui, Yue; Yu, Shan; Liu, Ning
  作者单位：Chinese Academy of Sciences; Institute of Biophysics, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Institute of Automation, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Institute of Automation, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
  摘要：Recently, extensive evidence has demonstrated that the brain operates close to a critical state, characterized by dynamic patterns known as neuronal avalanches. The critical state, reflecting the delicate balance between neural excitation and inhibition, offers numerous advantages in information processing. However, the role of genetics in shaping brain criticality is not fully understood. Whether there is any shared genetic factor influencing the critical state and cognitive functions remains...
• Make forensic case reports required legal and scientific documents AI翻译
  作者：Higley, Leon; Carter, David O.; Elowsky, Christian; Haskell, Christine; Haskell, Neal; Obanfunwa, John; Reinhard, Karl; Roe, Amanda; Schoenly, Ken; Simmons, Tal; Wells, Jeffrey
  作者单位：University of Nebraska System; University of Nebraska Lincoln; Chaminade University Honolulu; University of Nebraska System; University of Nebraska Lincoln; California State University System; California State University Stanislaus; Virginia Commonwealth University; State University System of Florida; Florida International University; State University System of Florida; Florida International University
• Bone morphogenetic protein-9 controls pulmonary vascular growth and remodeling AI翻译
  作者：Berrebeh, Nihel; Mbouamboua, Yvon; Thuillet, Raphael; Ottaviani, Mina; Robert, Fabien; Chelgham, Mustapha Kamel; Magnone, Virginie; Desroches-Castan, Agnes; Ricard, Nicolas; Anegon, Ignacio; Remy, Severine; Schermuly, Ralph Theo; Lebrigand, Kevin; Kojonazarov, Baktybek; Savale, Laurent; Humbert, Marc; Bailly, Sabine; Barbry, Pascal; Tu, Ly; Guignabert, Christophe
  作者单位：Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Saclay; Universite Paris Saclay; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Cote d'Azur; Centre National de la Recherche Scientifique (CNRS); Institut National de la Sante et de la Recherche Medicale (Inserm); CEA; Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); Nantes Universite; Institut National de la Sante et de la Recherche Medicale (Inserm); Justus Liebig University Giessen; Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Antoine-Beclere - APHP; Universite Paris Saclay; Hopital Universitaire Bicetre - APHP; Universite Cote d'Azur
  摘要：Pulmonary arterial hypertension (PAH) and hereditary hemorrhagic telangiectasia (HHT) are two distinct vascular diseases linked to impaired signaling through bone morphogenetic protein (BMP) receptor complexes in endothelial cells. Although BMP-9 plays a central role in activating this pathway by binding to ALK1 and BMPR-II, its precise function in the pulmonary microvasculature has remained unclear. In this study, we demonstrate a role for BMP-9 in regulating pulmonary vascular architecture a...
• The evolution of robustness and fragility during long- term bacterial adaptation (vol 122, e2501901122, 2025) AI翻译
  作者：Chihoub, Doha; Pintard, Coralie; Lenski, Richard E.; Tenaillon, Olivier; Couce, Alejandro
• A bioinspired and degradable riboflavin- containing polypeptide as a sustainable material for energy storage AI翻译
  作者：Li, Shih - Guo; Mohanty, Khirabdhi T.; Easley, Alexandra D.; Rezenom, Yohannes H.; Lim, Soon - Mi; Gillett, Leyla P.; Naquin, Stone D.; Tran, David K.; Nguyen, Tan P.; Lutkenhaus, Jodie L.; Wooley, Karen L.
  作者单位：Texas A&M University System; Texas A&M University College Station; Texas A&M University System; Texas A&M University College Station; Texas A&M University System; Texas A&M University College Station
  摘要：Inspired by Nature, we present a polypeptide-based organic redox-active material constructed from renewable feedstocks, L-glutamic acid (an amino acid) and riboflavin (vitamin B2), to address challenges with start-to-end-of-life management in energy storage systems (ESSs). The amino acid was utilized to establish a degradable polymer backbone, along which many copies of riboflavin were incorporated to serve as the redox-active pendant groups that enabled energy storage. The overall synthesis i...
• PIK3CA gain-of-function mutation in Schwann cells leads to severe neuropathy and aerobic glycolysis through a non-cell autonomous effect AI翻译
  作者：Venot, Quitterie; Firpion, Marina; Ladraa, Sophia; Bayard, Charles; Magassa, Sato; Di Guardo, Roberta; Fraissenon, Antoine; Hoguin, Clement; Protic, Sanela; Morin, Gabriel; Mayeux, Franck; Gourdon, Genevieve; Fraitag, Sylvie; Balducci, Estelle; Kaltenbach, Sophie; Villarese, Patrick; Asnafi, Vahid; Viel, Thomas; Autret, Gwennhael; Tavitian, Bertrand; Goudin, Nicolas; Guibaud, Laurent; Bolino, Alessandra; Canaud, Guillaume
  作者单位：Universite Paris Cite; Universite Paris Cite; Institut National de la Sante et de la Recherche Medicale (Inserm); Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Necker-Enfants Malades - APHP; Vita-Salute San Raffaele University; IRCCS Ospedale San Raffaele; CHU Lyon; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute for Engineering & Systems Sciences (INSIS); Institut National des Sciences Appliquees de Lyon - INSA Lyon; CHU de St Etienne; Institut National de la Sante et de la Recherche Medicale (Inserm); Sorbonne Universite; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Necker-Enfants Malades - APHP; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Necker-Enfants Malades - APHP; Universite Paris Cite; Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite; Vita-Salute San Raffaele University
  摘要：PIK3CA-related disorders are rare genetic disorders due to somatic gain-of-function mutations in PIK3CA during embryonic development, a pathway involved in cell growth, proliferation, and metabolism. Accumulating evidence from patients with PIK3CA-related disorders indicates that peripheral nerves are frequently affected, leading to severe neurological symptoms. However, the exact underlying mechanism of these disorders remains unclear. To address this, we developed a mouse model with a PIK3CA...
• Widespread thiamine deficiency in California salmon linked to an anchovy-dominated marine prey base AI翻译
  作者：Mantua, Nathan J.; Bell, Heather; Todgham, Anne E.; Daniels, Miles E.; Rinchard, Jacques; Ludwig, Jarrod M.; Field, John C.; Lindley, Steven T.; Rowland, Freya E.; Richter, Catherine A.; Walters, David; Finney, Bruce; Distajo, Haskell Anne R.; Tillitt, Donald; Honeyfield, Dale C.; Lipscomb, Taylor; Kwak, Kevin; Kindopp, Jason; Cocherell, Dennis; Ward, Abigail; Williams, Thomas H.; Harding, Jeff; Fangue, Nann A.; Jeffres, Carson; Ruiz-Cooley, Rocio I.; Litvin, Steven Y.; Foott, Scott; Adkison, Mark; Kormos, Brett; Harte, Peggy; Colwell, Frederick; Suffridge, Christopher P.; Shannon, Kelly C.; Cranford, Amanda; Ambrose, Charlotte; Reed, Aimee; Johnson, Rachel C.
  作者单位：National Oceanic Atmospheric Admin (NOAA) - USA; University of California System; University of California Davis; University of California System; University of California Davis; University of California System; University of California Santa Cruz; State University of New York (SUNY) System; State University of New York (SUNY) Brockport; United States Department of the Interior; United States Geological Survey; Idaho State University; Idaho State University; United States Department of the Interior; United States Geological Survey; United States Department of the Interior; US Fish & Wildlife Service; University of California System; University of California Davis; Moss Landing Marine Laboratories; Monterey Bay Aquarium Research Institute; University of California System; University of California Davis; Oregon State University
  摘要：Thiamine (vitamin B1) deficiency in marine systems is a globally significant threat to marine life. In 2020, newly hatched Chinook salmon (Oncorhynchus tshawytscha) fry in California's Central Valley (CCV) hatcheries swam in corkscrew patterns and died at unusually high rates due to a lack of this essential vitamin. We subsequently investigated the impacts and causes of thiamine deficiency in California's anadromous salmonids. Our laboratory studies defined the relationship between thiamine co...
• Structural mechanism for the recognition of E2F1 by the ubiquitin ligase adaptor Cyclin F AI翻译
  作者：Ngoi, Peter; Wang, Xianxi; Putta, Sivasankar; Da Luz, Ricardo F.; Serrao, Vitor Hugo B.; Emanuele, Michael J.; Rubin, Seth M.
  作者单位：University of California System; University of California Santa Cruz; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of California System; University of California Santa Cruz
  摘要：Cyclin F, a noncanonical member of the cyclin protein family, plays a critical role in regulating transitions in the cell division cycle. Unlike canonical cyclins, which bind and activate cyclin-dependent kinases (CDKs), Cyclin F functions as a substrate receptor protein within the Skp1-Cullin-F-box E3 ubiquitin ligase complex, enabling the ubiquitylation of target proteins. The structural features that distinguish Cyclin F as a ligase adaptor and the mechanisms underlying its selective substr...
• In situ NMR reveals a pH sensor motif in an outer membrane protein that drives bacterial vesicle production AI翻译
  作者：Wood, Nicholas A.; Kraft, Alyssa; Shin, Kyungsoo; Gopinath, Tata; Marassi, Francesca M.
  作者单位：Medical College of Wisconsin
  摘要：The outer membrane vesicles (OMVs) produced by diderm bacteria have important roles in cell envelope homeostasis, secretion, interbacterial communication, and pathogenesis. The facultative intracellular pathogen Salmonella enterica Typhimurium (STm) activates OMV biogenesis inside the acidic vacuoles of host cells by upregulating the expression of the OM protein PagC, one of the most robustly activated genes in a host environment. Here, we used solid- state nuclear magnetic resonance (NMR) and...