26期

最新文章

• Enhanced chloroplast FtsZ-ring constriction by the ARC6-ARC3 module in Arabidopsis AI翻译
  作者：Du, Wenbin; Cao, Lingyan; Zhou, Yuelong; Jackson, Shanelle; Naeem, Maryam; Chen, Zhaoyu; Yang, Yue; Glynn, Jonathan M.; Porter, Katie J.; Zhang, Runlong; He, Qian; Liu, Moyang; Xu, Jie; Liang, Wanqi; Feng, Peiqiang; Osteryoung, Katherine W.; Chen, Cheng
  作者单位：Jiangxi Agricultural University; Pfizer; Pfizer USA; Shanghai Jiao Tong University; Shanghai Jiao Tong University; Michigan State University; Chinese Academy of Sciences; Center for Excellence in Molecular Plant Sciences, CAS; Shanghai Jiao Tong University; Shanghai Jiao Tong University; Shanghai Jiao Tong University
  摘要：Chloroplast division, a process tightly linked to the energy demands of plants, is initiated by the formation of the stromal filamenting temperature-sensitive Z (FtsZ) ring. The Z ring is highly dynamic, and its constriction provides the essential force for chloroplast division. However, the regulatory mechanisms governing Z-ring dynamics and constriction remain poorly understood. Here, we report that the chloroplast inner envelope membrane (IEM) protein ACCUMULATION AND REPLICATION OF CHLOROP...
• Relaxation to universal non- Maxwellian equilibria in a collisionless plasma (vol 122, e2417813122, 2025) AI翻译
  作者：Ewart, Robert J.; Nastac, Michael L.; Bilbao, Pablo J.; Silva, Thales; Silva, Luis O.; Schekochihin, Alexander A.
• Editorial Expression of Concern for Fries et al., Early experience in humans is associated with changes in neuropeptides critical for regulating social behavior AI翻译
  作者：Fries, Alison B. Wismer; Ziegler, Toni E.; Kurian, Joseph R.; Jacoris, Steve; Pollak, Seth D.
• Crystal structure and catalytic mechanism of drimenol synthase, an unusual bifunctional terpene cyclase-phosphatase AI翻译
  作者：Osika, Kristin R.; Gaynes, Matthew N.; Christianson, David W.
  作者单位：University of Pennsylvania
  摘要：Drimenol synthase from Aquimarina spongiae (AsDMS) is a highly unusual chimera that integrates two distinct, sequential isoprenoid processing activities within a single polypeptide chain. AsDMS catalyzes the class II cyclization of farnesyl diphosphate (FPP) to form drimenyl diphosphate, which then undergoes enzyme- catalyzed hydrolysis to yield drimenol, a bioactive sesquiterpene alcohol with antifungal and anticancer properties. Here, we report the X- ray crystal structures of AsDMS and its ...
• Comparative performance of viral landscape phylogeography approaches AI翻译
  作者：Dellicour, Simon; Gambaro, Fabiana; Jacquot, Maude; Lequime, Sebastian; Baele, Guy; Gilbert, Marius; Pybus, Oliver G.; Suchard, Marc A.; Lemey, Philippe
  作者单位：Universite Libre de Bruxelles; KU Leuven; Vrije Universiteit Brussel; Universite Libre de Bruxelles; Ifremer; University of Groningen; University of Oxford; University of London; University of London Royal Veterinary College; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA
  摘要：The rapid evolution of RNA viruses implies that their evolutionary and ecological processes occur on the same time scale. Genome sequences of these pathogens therefore can contain information about the processes that govern their transmission and dispersal. Landscape phylogeographic approaches use phylogeographic reconstructions to investigate the impact of environmental factors and variables on the spatial spread of viruses. Here, we extend and improve existing approaches and develop three no...
• NBS1 facilitates preribosomal RNA biogenesis (vol 122, e2422029122, 2025) AI翻译
  作者：Luo, Man; Yu, Xiaochun
• Diploidization in a wild rice allopolyploid is both episodic and gradual AI翻译
  作者：Wang, Xin; Li, Ning; Wang, Qian; Lei, Tian-Yu; Zhou, Ju; Zhang, Fu-Min; Liao, Xue-Zhu; Qiang, Cheng-Gen; Yu, Wen-Hao; Han, Jing-Dan; Ye, Ya-Rong; Jing, Chun-Yan; Wang, Mei-Xia; Gao, Qiang; Chen, Jin-Feng; Jiao, Yuan-Nian; Wu, Zhi-Qiang; Guo, Ya-Long; Wing, Rod A.; Doyleh, Jeff J.; Ge, Song; Zou, Xin- Hui
  作者单位：Chinese Academy of Sciences; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Guangdong Laboratory for Lingnan Modern Agriculture; Chinese Academy of Agricultural Sciences; Agriculture Genomes Institute at Shenzhen, CAAS; Chinese Academy of Sciences; Institute of Zoology, CAS; University of Arizona; Cornell University
  摘要：Polyploid organisms evolve from their initial doubled genomic condition through a number of processes collectively termed diploidization, whose tempo and mode remain poorly understood mainly due to the difficulty of discriminating de novo evolution subsequent to polyploidy from variation inherited from progenitors. Here, we generated chromosome-scale genome assemblies for the wild rice allopolyploid Oryza minuta and its two diploid progenitors, Oryza punctata and Oryza officinalis, and employe...
• The adaptive state determines the impact of mutations on evolving populations AI翻译
  作者：Weh, Malgorzata Tyczynska; Kumar, Pragya; Marusyk, Viktoriya; Marusyk, Andriy; Basanta, David
  作者单位：H Lee Moffitt Cancer Center & Research Institute; State University System of Florida; University of South Florida; H Lee Moffitt Cancer Center & Research Institute
  摘要：Darwinian evolution results from an interplay between stochastic diversification of heritable phenotypes, impacting the chance of survival and reproduction, and fitness-based selection. The ability of populations to evolve and adapt to environmental changes depends on rates of mutational diversification and the distribution of fitness effects of random mutations. In turn, the distribution of fitness effects of stochastic mutations can be expected to depend on the adaptive state of a population...
• Ena/VASP-EVH1 inhibition prevents chemotaxis and metastasis by blocking the EVH1-WAVE2 interaction AI翻译
  作者：Mueller, Matthias; Barone, Matthias; van Dinther, Maarten; Motzny, Kathrin; Ren, Jiang; Eichhorst, Jenny; Albat, Dominik; Chiha, Slim; Lehmann, Martin; Volkmer, Rudolf; Oschkinat, Hartmut; Schmalz, Hans-Guenther; ten Dijke, Peter; Kuehne, Ronald
  作者单位：Leibniz Association; Leibniz Forschungsinstitut furr Molekulare Pharmakologie (FMP); Humboldt University of Berlin; Free University of Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health; Leiden University - Excl LUMC; Leiden University; Leiden University Medical Center (LUMC); University of Cologne
  摘要：Cancer therapy would benefit from suppressing cancer cell motility in the process of metastasis. Such directed cell migration relies on the propulsive force established by the filamentous actin network within lamellipodia. Proteins of the Ena/VASP family and the WAVE regulatory complex orchestrate lamellar protrusions and therefore provide promising targets for pharmacological interventions. Here, we report a cross-talk between Ena/VASP proteins and WAVE2 that is important for cancer cell extr...
• Global kinetic model of lipid-induced a-synuclein aggregation and its inhibition by small molecules AI翻译
  作者：Stevenson, Alisdair; Staats, Roxine; Dear, Alexander J.; Voderholzer, David; Dreier, Jesper E.; Meisl, Georg; Guido, Raphael; Knowles, Tuomas P. J.; Galvagnion, Celine; Buell, Alexander K.; Vendruscolo, Michele; Michaels, Thomas C. T.
  作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Cambridge; University of Copenhagen; Technical University of Denmark
  摘要：The aggregation of a-synuclein into amyloid fibrils is a hallmark of Parkinson's disease. This process has been shown to directly involve interactions between proteins and lipid surfaces when the latter are present. Despite this importance, the molecular mechanisms of lipid-induced amyloid aggregation have remained largely elusive. Here, we present a global kinetic model to describe lipid-induced amyloid aggregation of a-synuclein. Using this framework, we find that a-synuclein fibrils form vi...