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作者：Gao, Xufeng; Zhou, Peng; Yuan, Xu; Li, Xiaoxu; Li, Bowen; Xia, Yu; Meng, Yifan; Zare, Richard N.; Zheng, Tingting; Zhang, Xinxing
作者单位：Nankai University; East China Normal University; Jianghan University; Stanford University
摘要：Adhesive interfaces store significant energy due to interlocking molecular chain entanglement and van der Waals forces. When two adhesive surfaces are separated, triboelectric effects induce charge transfer, generating a strong electric field at the peeling interface. This effect offers different opportunities for initiating chemical reactions. Here, we report that the stick-slip friction involved in peeling tape produces electric fields on the order of 109 V/m, as measured by the vibrational ...
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作者：He, Dongyin; Zhang, Luyao; Yu, Leiye; Zhang, Yuhang; Chen, Jingjing; Wang, Leibo; Hu, Haoran; Liu, Hongyu; Zheng, Hong; Xia, Jixin; Chen, Jiahui; Li, Chenhui; Li, Xin; Tang, Huiru; Liu, Jia; Ren, Ruobing; Hu, Youhong; Li, Zhenfei
作者单位：Chinese Academy of Sciences; Center for Excellence in Molecular Cell Science, CAS; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Fudan University; Shanghai Jiao Tong University; Fudan University; Chinese Academy of Sciences; Shanghai Institute of Nutrition & Health, CAS; University of Chinese Academy of Sciences, CAS; The Chinese University of Hong Kong, Shenzhen; Chinese Academy of Sciences; Shanghai Institute of Materia Medica, CAS; Shandong Laboratory of Yantai Drug Discovery; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
摘要：Prostate cancer is a global health challenge, particularly for patients resistant to the second-generation anti-androgen receptor pathway inhibitors. The steroidogenic enzyme 3 beta-hydroxysteroid dehydrogenase type 1 (3 beta HSD1) has emerged as a promising therapeutic target and the corresponding inhibitors, biochanin-A (BCA) and its derivatives, suppress tumor growth in preclinical models and patients. However, the poor oral bioavailability of BCA hinders its clinical application. Here, we ...
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作者：Kessinger, Taylor A.; Plotkin, Joshua B.
作者单位：University of Pennsylvania; University of Pennsylvania
摘要：Indirect reciprocity is a compelling explanation for stable cooperation in a large society: Those who cooperate appropriately earn a good standing, so that others are more likely to cooperate with them. However, this mechanism requires a population to agree on who has good standing and who has bad standing. Consensus can be provided by a central institution that monitors and broadcasts reputations. But how might such an institution be maintained, and how can a population ensure that it is effe...
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作者：Han, Chenxu; Zong, Hongxiang; Ding, Xiangdong; Sun, Jun; Ackland, Graeme J.
作者单位：Xi'an Jiaotong University; University of Edinburgh
摘要：Liquid-liquid phase transitions (LLPTs) are typically characterized as two-state systems, where transitions occur between two distinct liquid phases driven by local structural rearrangements. In this study, we observed a continuous LLPT with an inversion of electronegativity in a K-Rb binary alloy. This uniquely exhibits a three-state system behavior. The transition, induced by pressure-driven reordering of electronic orbital energies, progresses through a sequence from s-metal to electride to...
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作者：Juraszek, Jarek; Kadam, Rameshwar U.; Branduardi, Davide; van Ameijde, Jeroen; Garg, Divita; Dailly, Nicolas; Jongeneelen, Mandy; Vermond, Jan; Brakenhoff, Just P. J.; Brandenburg, Boerries; van Dongen, Maria J. P.; Vogels, Ronald; Friesen, Robert H. E.; Wilson, Ian A.
作者单位：Scripps Research Institute; Scripps Research Institute; Scripps Research Institute; Astex Pharmaceuticals
摘要：D-peptides hold great promise as therapeutics by alleviating the challenges of metabolic stability and immunogenicity in L-peptides. However, current D-peptide discovery methods are severely limited by specific size, structure, and the chemical synthesizability of their protein targets. Here, we describe a computational method for de novo design of D-peptides that bind to an epitope of interest on the target protein using Rosetta's hotspot-centric approach. The approach comprises identifying h...
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作者：Yoshida, Atsushi; Hikosaka, Okihide
作者单位：National Institutes of Health (NIH) - USA; NIH National Eye Institute (NEI); Hokkaido University
摘要：The basal ganglia play a crucial role in action selection by facilitating desired movements and suppressing unwanted ones. The substantia nigra pars reticulata (SNr), a key output nucleus, facilitates movement through disinhibition of the superior colliculus (SC). However, its role in action suppression, particularly in primates, remains less clear. We investigated whether individual SNr neurons in three male macaque monkeys bidirectionally modulate their activity to both facilitate and suppre...
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作者：Lee, Jonathan Y.
作者单位：Stanford University
摘要：In recent years, trust in US public health and science institutions has faced unprecedented declines, particularly among Republicans/conservatives. To what extent might institutional criticism on social media be responsible for such politically polarized declines in institutional trust? Two online survey experiments (total N = 6,800), using samples roughly reflective of the US adult population, examined the effects of key types of criticism against the Agency for Healthcare Research and Qualit...
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作者：Martin, Chris C.; Lockley, Andrew; Hendricks, Steve; Clark, Cory J.; Mundra, Ishita; Matzner, Nils
作者单位：University System of Georgia; Georgia Institute of Technology; University of Pennsylvania; University of Washington; University of Washington Seattle; Technical University of Munich; Helmholtz Association; Helmholtz Center for Environmental Research (UFZ)
摘要：Scholars have long been concerned about gender representation in scientific research but there has been little work on gender differences in participation and performance in climate science, a field that engages with both male-majority disciplines (e.g., geosciences, engineering) and female-majority disciplines (e.g., life sciences, medical science). This has implications for both gender equity and viewpoint representation. Sampling over 400,000 publications and a similar number of authors, we...
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作者：Smitha, Gregory P.; Zhub, Chenhui; Zhernenkovc, Mikhail; Freychetd, Guillaume; Clarka, Noel A.; Zhernenkov, Mikhail; Freychet, Guillaume; Clark, Noel A.
作者单位：University of Colorado System; University of Colorado Boulder; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; United States Department of Energy (DOE); Brookhaven National Laboratory; CEA; Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA)
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作者：Wu, Xin- Rui; Yang, Liu; Wu, Bang- Sheng; Cheng, Wei; Yu, Jin- Tai
作者单位：Fudan University; Fudan University; Fudan University; Fudan University; Fudan University
