26期

最新文章

• The RRM domain-containing protein Rbp3 interacts with ribosomes and the 3' ends of mRNAs encoding photosynthesis proteins AI翻译
  作者：Hemm, Luisa; Lichtenberg, Elisabeth; Tholen, Stefan; Reimann, Viktoria; Kakazu, Kenta; Machida, Sotaro; Mahbub, Moontaha; Schilling, Oliver; Wilde, Annegret; Watanabe, Satoru; Mullineaux, Conrad W.; Hess, Wolfgang R.
  作者单位：University of Freiburg; University of Freiburg; University of Freiburg; Tokyo University of Agriculture; University of London; Queen Mary University London
  摘要：RNA recognition motif (RRM) domain proteins are crucial RNA- binding proteins across all domains of life. In cyanobacteria, single RRM domain proteins are involved in mRNA targeting to the thylakoid membrane and acclimation to certain stress conditions, but many details of their physiological functions and molecular targets have remained unknown. The model cyanobacterium Synechocystis sp. PCC 6803 has a family of three genes encoding the RRM domain-containing proteins Rbp1, Rbp2, and Rbp3. Her...
• Inhibiting Nav1.8 for pain: Lessons from patients and from neurons AI翻译
  作者：Waxman, Stephen G.; V. Vasylyev, Dmytro
  作者单位：Yale University; Yale University; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA Connecticut Healthcare System
• The role of estrogen receptor β in maintaining basal cells and modulating the immune environment in the prostate AI翻译
  作者：Wu, Wan-fu; Song, Xiao-yu; Warner, Margaret; Imamov, Otabeck; Antonson, Per; Gustafsson, Jan-Ake
  作者单位：University of Houston System; University of Houston; Karolinska Institutet
  摘要：Estrogen receptor R (ERR) plays an important role in both the mouse and human prostate. The endogenous ligand for ERR is the dihydrotestosterone metabolite, 5R-androstane-3R, 17R-diol (3R-Adiol). Thus, treatment with 5-alpha reductase inhibitor (5-ARI) should produce a phenotype similar to that seen in ERR-/- mice. By comparing RNA-Seq of the ventral prostates (VP) of ERR knockout mice (ERRcrispr-/-) and wild-type (WT) mice, we confirmed that ERR modulates androgen receptor (AR) signaling indi...
• Spatial metabolomics informs the use of clinical imaging for improved detection of cribriform prostate cancer AI翻译
  作者：Sushentsev, Nikita; Hamm, Gregory; Manavaki, Roido; McLean, Mary A.; Birchall, Jonathan; Soloviev, Dmitry; Lewis, David Y.; Aloj, Luigi; Flint, Lucy; Zakirov, Aleksandr; Mills, Ian G.; Gnanapragasam, Vincent J.; Warren, Anne Y.; Barry, Simon T.; Goodwin, Richard J. A.; Gallagher, Ferdia A.; Barrett, Tristan
  作者单位：Cambridge University Hospitals NHS Foundation Trust; Addenbrooke's Hospital; University of Cambridge; University of Cambridge; AstraZeneca; University of Glasgow; University of Cambridge; University of Oxford; Queens University Belfast; Aarhus University; Cambridge University Hospitals NHS Foundation Trust; Addenbrooke's Hospital; University of Cambridge; AstraZeneca
  摘要：Cribriform prostate cancer (crPCa) is associated with poor clinical outcomes, yet its accurate detection remains challenging due to the poor sensitivity of standard- of- care diagnostic tools. Here, we use untargeted spatial metabolomics to identify fatty acid biosynthesis as a key metabolic pathway enriched in crPCa epithelium. We also show that imaging tumor copy differentiates cribriform from noncribriform intermediate- risk prostate cancers in two prospective patient cohorts. These finding...
• Multiomics integration prioritizes potential drug targets for multiple sclerosis AI翻译
  作者：Jiang, Yuan; Liu, Qianwen; Stridh, Pernilla; Kockum, Ingrid; Olsson, Tomas; Alfredsson, Lars; Diaz-Gallo, Lina - Marcela; Jiang, Xia
  作者单位：Karolinska Institutet; Karolinska Institutet; Karolinska Institutet; Sichuan University; Sichuan University
  摘要：Multiple sclerosis (MS) is an immune-mediated disease with no current cure. Drug discovery and repurposing are essential to enhance treatment efficacy and safety. We utilized summary statistics for protein quantitative trait loci (pQTL) of 2,004 plasma and 1,443 brain proteins, a genome-wide association study of MS susceptibilitywith 14,802 cases and 26,703 controls, both bulk and cell-type specific transcriptome data, and external pQTL data in blood and brain. Our integrative analysis include...
• Population structure limits the use of genomic data for predicting phenotypes and managing genetic resources in forest trees AI翻译
  作者：Slavov, Gancho T.; Macaya-Sanz, David; DiFazio, Stephen P.; Howe, Glenn T.
  作者单位：UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); Institute of Biological, Environmental, Rural & Sciences (IBERS); Aberystwyth University; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); Rothamsted Research; West Virginia University; Consejo Superior de Investigaciones Cientificas (CSIC); Oregon State University
  摘要：There is overwhelming evidence that forest trees are locally adapted to climate. Thus, genecological models based on population phenotypes have been used to measure local adaptation, infer genetic maladaptation to climate, and guide assisted migration. However, instead of phenotypes, there is increasing interest in using genomic data for gene resource management. We used whole-genome resequencing and common-garden experiments to understand the genetic architecture of adaptive traits in black c...
• The importance of small-island populations for the long-term survival of endangered large-bodied insular mammals AI翻译
  作者：Aninta, Sabhrina Gita; Drinkwater, Rosie; Carmagnini, Alberto; Deere, Nicolas J.; Priyono, Dwi Sendi; Andayani, Noviar; Winarni, Nurul L.; Supriatna, Jatna; Fumagalli, Matteo; Larson, Greger; Galbusera, Peter H. A.; Macdonald, Alastair; Greer, Deborah; Mohamad, Kusdiantoro; Prasetyaningtyas, Wahono Esthi; Mustari, Abdul Haris; Williams, John Lewis; Barnett, Ross; Shaw, Darren; Semiadi, Gono; Burton, James; Seaman, David J. I.; Voigt, Maria; Struebig, Matthew J.; Brace, Selina; Rossiter, Stephen J.; Frantz, Laurent
  作者单位：University of London; Queen Mary University London; University of Munich; University of Kent; Gadjah Mada University; University of Indonesia; University of Indonesia; University of Oxford; University of Edinburgh; Catholic University of the Sacred Heart; Durham University; Natural History Museum London
  摘要：Island populations of large vertebrates have experienced higher extinction rates than mainland populations over long timescales due to demographic stochasticity, genetic drift, and inbreeding. While being more susceptible to extinction and as such potentially targeted for conservation interventions such as genetic rescue, small-island populations can experience relatively less anthropogenic habitat degradation than those on larger islands. Here, we determine the consequences and conservation i...
• Supporting Information for Bardy et al., Neuronal medium that supports basic synaptic functions and activity of human neurons in vitro (vol 112 , E2725-E2734 , 2015 ) AI翻译
  作者：Bardy, Cedric; van den Hurk, Mark; Eames, Tameji; Marchand, Cynthia; Hernandez, Ruben, V; Kellogg, Mariko; Gorris, Mark; Galet, Ben; Palomares, Vanessa; Brown, Joshua; Bang, Anne G.; Mertens, Jeorme; Bohnke, Lena; Boyer, Leah; Simon, Suzanne; Gage, Fred H.
• Generative AI without guardrails can harm learning: Evidence from high school mathematics AI翻译
  作者：Bastani, Hamsa; Bastani, Osbert; Sungu, Alp; Ge, Haosen; Kabakci, Ozge; Mariman, Rei
  作者单位：University of Pennsylvania; University of Pennsylvania
  摘要：Generative AI is poised to revolutionize how humans work, and has already demonstrated promise in significantly improving human productivity. A key question is how generative AI affects learning-namely, how humans acquire new skills as they perform tasks. Learning is critical to long-term productivity, especially since generative AI is fallible and users must check its outputs. We study this question via a field experiment where we provide nearly a thousand high school math students with acces...
• PLAA/UFD-3 regulates P- bodies through its intrinsic disordered domain AI翻译
  作者：Das, Alakananda; Qiu, Yanping; Wolf, Trevor J.; Brissett, Ella; Cho, Jaehyoung; Park, Heenam; Chen, Eugene C.; Chou, Tsui - Fen; Sternberg, Paul W.
  作者单位：California Institute of Technology; Claremont Colleges; Claremont Graduate University; Claremont McKenna College
  摘要：Regulation of proteome homeostasis is crucial for the survival and adaptation to changing environments for all species. In eukaryotes, this process is finely tuned through regulation at the level of transcription, translation, protein modification, and protein degradation. The phospholipase A2 activating protein (PLAA) is present in all eukaryotes and believed to be a key player in ubiquitin-dependent protein sorting and degradation via its interactions with ubiquitin and/or the AAA+ ATPase, v...