30期

最新文章

• 撤稿声明: Selective neutralization of IL-12 p40 monomer induces death in prostate cancer cells via IL-12-IFN-γ AI翻译
  作者：Kundu, Madhuchhanda; Roy, Avik; Pahan, Kalipada
• RACK1A positively regulates opening of the apical hook in Arabidopsis thaliana via suppression of its auxin response gradient AI翻译
  作者：Ma, Qian; Liu, Sijia; Doyle, Siamsa M.; Raggi, Sara; Parizkova, Barbora; Barange, Deepak Kumar; Ratnakaram, Hemamshu; Wilkinson, Edward G.; Garcia, Isidro Crespo; Bygdell, Joakim; Wingsle, Gunnar; Boer, Dirk Roeland; Strader, Lucia C.; Almqvist, Fredrik; Novak, Ondrej; Robert, Stephanie
  作者单位：Swedish University of Agricultural Sciences; Umea University; Palacky University Olomouc; Czech Academy of Sciences; Institute of Experimental Botany of the Czech Academy of Sciences; Umea University; Duke University; Umea University; Ghent University; Flanders Institute for Biotechnology (VIB); Shenyang Agricultural University; Swedish University of Agricultural Sciences; Umea University; Colorado State University System; Colorado State University Fort Collins
  摘要：Apical hook development is an ideal model for studying differential growth in plants and is controlled by complex phytohormonal crosstalk, with auxin being the major player. Here, we identified a bioactive small molecule that decelerates apical hook opening in Arabidopsis thaliana. Our genetic studies suggest that this molecule enhances or maintains the auxin maximum found in the inner hook side and requires certain auxin signaling components to direct target of this compound. We present data ...
• Amino acid transfer free energies reveal thermodynamic driving forces in biomolecular condensate formation AI翻译
  作者：Rekhi, Shiv; Mittal, Jeetain
  作者单位：Texas A&M University System; Texas A&M University College Station; Texas A&M University System; Texas A&M University College Station; Texas A&M University System; Texas A&M University College Station
  摘要：The self-assembly of intrinsically disordered proteins into biomolecular condensates depends on their primary sequence, leading to sequence-dependent phase separation. Computational methods to study this behavior often rely on residue-level interaction potentials that estimate the propensity of amino acids to partition between the dilute and dense phases. While distribution coefficients would provide the most direct measure of these potentials, their unavailability has led to the use of proxie...
• Trigger factor accelerates nascent chain compaction and folding AI翻译
  作者：Till, Katharina; Seinen, Anne-Bart; Wruck, Florian; Sunderlikova, Vanda; Galmozzi, Carla V.; Katranidis, Alexandros; Bukau, Bernd; Kramer, Guenter; Tans, Sander J.
  作者单位：AMOLF; Helmholtz Association; German Cancer Research Center (DKFZ); Consejo Superior de Investigaciones Cientificas (CSIC); University of Sevilla; CSIC-JA-USE - Instituto de Biomedicina de Sevilla (IBIS); Delft University of Technology
  摘要：Conformational control of nascent chains is poorly understood. Chaperones are known to stabilize, unfold, and disaggregate polypeptides away from the ribosome. In comparison, much less is known about the elementary conformational control mechanisms at the ribosome. Yet, proteins encounter major folding and aggregation challenges during translation. Here, using selective ribosome profiling and optical tweezers with correlated single- molecule fluorescence, with dihydrofolate reductase (DHFR) as...
• Gibberellin- deactivating GA2OX enzymes act as a hub for auxin-gibberellin cross talk in Arabidopsis thaliana root growth regulation AI翻译
  作者：Kubalova, Monika; Griffiths, Jayne; Mueller, Karel; Levenets, Lev; Tylova, Edita; Tarkowska, Danuse; Jones, Alexander M.; Fendrych, Matyas
  作者单位：Czech Academy of Sciences; Institute of Experimental Botany of the Czech Academy of Sciences; Charles University Prague; University of Cambridge; Palacky University Olomouc; Czech Academy of Sciences; Institute of Experimental Botany of the Czech Academy of Sciences; Palacky University Olomouc
  摘要：Plant bodies are built from immobile cells, making the regulation of cell expansion essential for growth, development, and adaptation. In roots, cell elongation executes the movement of the root tips through the soil. This process is tightly controlled by numerous signaling pathways. Among these, gibberellin and auxin signaling stand out for their contrasting effects on root growth, interacting through complex cross talk at multiple regulatory levels. Here, we reveal the molecular basis of the...
• Lipid residue analysis reveals divergent culinary practices in Japan and Korea at the dawn of intensive agriculture AI翻译
  作者：Craig, Oliver E.; Lundy, Jasmine; Bondetti, Manon; Nicholson-Lailey, Sesha; Murakami, Natsuki; Suzuki, Miho; Stevens, Chris; Lucquin, Alexandre; Talbot, Helen M.; Son, Joon- ho; Fujio, Shinichiro; Sakamoto, Minoru; Yamashita, Yusuke; Kobayashi, Kenichi; Crema, Enrico R.; Shoda, Shinya
  作者单位：University of York - UK; University of London; University College London; Korea University; Chuo University; University of Cambridge
  摘要：The dispersal of millet and rice agriculture from Korea to Japan from around 3,000 y ago has been well documented through radiocarbon analysis of botanical remains and surveying seed impressions on pottery. Much less is known about the extent to which these novel crops were consumed and incorporated into everyday culinary practices. In Japan, agriculturalists moving from Korea would have encountered large, sedentary Final Jomon populations who had well-established hunting, foraging, and cultiv...
• BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1-Chk1 pathway, implicating checkpoint dysfunction in microcephaly (vol. 102, pg. 15105, 2005) AI翻译
  作者：Lin, Shiaw-Yi; Rai, Rekha; Li, Kaiyi; Xu, Zhi-Xiang; Elledge, Stephen J.
• A quantitative figure of merit for battery SEI films and their use as functional solid- state electrolytes AI翻译
  作者：Liu, Bo; Zhao, Dingyi; Lyle, Katelyn; Yuan, Xintong; Chen, Po - Hung; Zhang, Xinyue; Kim, Jin Koo; Wang, Tian - Yu; Wu, Haoyang; Wang, Chongzhen; Yu, Jiayi; Liang, Keyue; Kim, Jung Tae; Liang, Kaiyan; Li, Yuzhang
  作者单位：University of California System; University of California Los Angeles; University of California System; University of California Los Angeles
  摘要：As a key passivation film that governs battery operation, the solid electrolyte interphase (SEI) has long been credited for enabling high-performance batteries or blamed for their eventual death. However, qualitative descriptions of the SEI often found in the literature (e.g., conductive, passivating) highlight our incomplete understanding of this layer, where even the most basic properties foundational to SEI function remain difficult to measure. Here, we quantify SEI conductivities and SEI t...
• Tenure and research trajectories AI翻译
  作者：Tripodi, Giorgio; Zheng, Xiang; Qian, Yifan; Murray, Dakota; Jones, Benjamin F.; Ni, Chaoqun; Wang, Dashun
  作者单位：Northwestern University; Northwestern University; Northwestern University; Northwestern University; University of Wisconsin System; University of Wisconsin Madison; Northeastern University; National Bureau of Economic Research; Northwestern University
  摘要：Tenure is a cornerstone of the US academic system, yet its relationship to faculty research trajectories remains poorly understood. Conceptually, tenure systems may act as a selection mechanism, screening in high-output researchers; a dynamic incentive mechanism, encouraging high output prior to tenure but low output after tenure; and a creative search mechanism, encouraging tenured individuals to undertake high-risk work. Here, we integrate data from seven different sources to trace US tenure...
• Supporting Information for Seigneur et al., Cbln2 and Cbln4 are expressed in distinct medial habenula-interpeduncular projections and contribute to different behavioral outputs (vol 115, pg E10235, 2018) AI翻译
  作者：Seigneur, Erica; Polepalli, Jai S.; Sudhof, Thomas C.