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作者：Nemhauser, Jennifer L.; Weigel, Detlef
作者单位：University of Washington; University of Washington Seattle
摘要：Joanne Chory (1955-2024) was a pioneering biologist whose research transformed our understanding of plant growth and development. Her groundbreaking work, based on many clever genetic screens, established a complete signaling pathway for brassinosteroids, from the biosynthesis of this important class of plant hormones and their transmembrane receptor to cytoplasmic and nuclear effectors. A beloved mentor and visionary leader, Chory championed science as both a rigorous discipline and a force f...
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作者：Piekarski, Patrick K.; Valdes-Rodriguez, Stephany; Trible, Waring; Kronauer, Daniel J. C.
作者单位：Rockefeller University; Rockefeller University; Howard Hughes Medical Institute; Harvard University
摘要：Polyphenic traits in animals often exhibit nonlinear scaling with body size. Static allometries (i.e., scaling relationships) themselves can exhibit plasticity, such that individuals of the same size and genotype differ in body proportions across different environments. In ants, both larval environment and genotype regulate the expression of caste- associated traits, including body size and ovariole number. However, it remains untested whether caste- associated traits are independently regulat...
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作者：Wang, Feng; He, Qing; O'Donnell, Michael E.; Li, Huilin
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作者：Heath-Heckman, Elizabeth
作者单位：Michigan State University; Michigan State University
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作者：Yanagisawa, Kuniaki; Nakai, Ryusuke; Asano, Kohei; Kashima, Emiko S.; Sugiura, Hitomi; Abe, Nobuhito
作者单位：Kobe University; Kyoto University; University of Osaka; La Trobe University
摘要：Optimism is a critical personality trait that influences future-oriented cognition by emphasizing positive future outcomes and deemphasizing negative outcomes. How does the brain represent idiosyncratic differences in episodic future thinking that are modulated by optimism? In two functional MRI (fMRI) studies, participants were scanned during an episodic future thinking task in which they were presented with a series of episodic scenarios with different emotional valence and prompted to imagi...
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作者：Luo, Canhuang; Ester, Edward F.
作者单位：Shenzhen University; Nevada System of Higher Education (NSHE); University of Nevada Reno; Nevada System of Higher Education (NSHE); University of Nevada Reno
摘要：Traveling waves guide the spatial propagation of neural activity and computational processes across the brain. Traveling waves could contribute to the control of memory- guided behaviors by flexibly organizing the timing and direction of interactions between brain regions responsible for storing memory content with those responsible for producing task- relevant behaviors. Using short- term memory as a test case, we report evidence supporting this possibility. Analyses of human EEG data reveale...
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作者：Lin, Yiyan; Parajon, Eleana; Yuan, Qinling; Ye, Siyu; Qin, Guanghui; Deng, Yu; Borleis, Jane; Koyfman, Ariel; Iglesias, Pablo A.; Konstantopoulos, Konstantinos; Robinson, Douglas N.; Devreotes, Peter N.
作者单位：Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; Microsoft; Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; Johns Hopkins University
摘要：Ras has traditionally been regarded as a positive regulator and therapeutic target due to its role in cell proliferation, but recent findings indicate a more nuanced role in cell migration, where suppressed Ras activity can unexpectedly promote migration. To clarify this complexity, we systematically modulate Ras activity using various RasGEF and RasGAP proteins and assess their effects on migration dynamics. Leveraging optogenetics, we assess the immediate, nontranscriptional effects of Ras s...
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作者：Soom, Sarah; Moning, Stefan Urs; Cook, Gregory M.; Lingford, James P.; Kropp, Ashleigh; Tran, Sieu; Grinter, Rhys; Greening, Chris; von Ballmoos, Christoph
作者单位：University of Bern; University of Bern; University of Otago; Queensland University of Technology (QUT); Monash University; Monash University; University of Melbourne; Monash University; Monash University
摘要：All cells require a continuous supply of the universal energy currency, adenosine triphosphate (ATP), to drive countless cellular reactions. The universally conserved F1Fo-ATP synthase regenerates ATP from ADP and Pi by harnessing a transmembrane electrochemical proton gradient (pmf). Bacteria have evolved diverse pmf-forming strategies using light, organic, and inorganic energy sources. Recently, we proposed that many bacteria survive using atmospheric trace gases to produce ATP when limited ...
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作者：Tang, Weiwei; Yang, Taimin; Tu, Qing; Calderon, Hector A.; Hernandez, Francisco C. Robles; O'Reilly, Padraic; Jing, Yun; Park, Sung; Rimer, Jeffrey D.
作者单位：University of Houston System; University of Houston; Tianjin University; Stockholm University; Texas A&M University System; Texas A&M University College Station; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory
摘要：Understanding and exploiting material flexibility through phenomena such as the bending and twisting of molecular crystals has been a subject of increased interest owing to the number of applications that benefit from these properties, such as optoelectronics, mechanophotonics, soft robotics, and smart sensors. Here, we report the growth of spontaneously bent and twisted ammonium urate crystals induced by the keto-enol tautomerism of the urate molecule. The major tautomer is native to biogenic...
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作者：Frederick, Jane; Virk, Ranya K. A.; Ye, I. Chae; Almassalha, Luay M.; Wodarcyk, Greta M.; VanDerway, David; Gong, Ruyi; Dunton, Cody L.; Kuo, Tiffany; Medina, Karla I.; Loxas, Margarita; Ahrendsen, Jared T.; Gursel, Demirkan B.; Gonzalez, Paola Carrillo; Nap, Rikkert J.; John, Saira; Agrawal, Vasundhara; Anthony, Nicholas M.; Carinato, John; Li, Wing Shun; Kakkaramadam, Rivaan; Jain, Surbhi; Shahabi, Shohreh; Ameer, Guillermo A.; Szleifer, Igal G.; Backman, Vadim
作者单位：Northwestern University; Northwestern University; Northwestern University; University of California System; University of California San Francisco; Northwestern University; Feinberg School of Medicine; Northwestern University; Feinberg School of Medicine; Northwestern University; Feinberg School of Medicine; Northwestern University
摘要：Cancer cells exhibit a remarkable resilience to cytotoxic stress, often adapting through transcriptional changes linked to alterations in chromatin structure. In several types of cancer, these adaptations involve epigenetic modifications and restructuring of topologically associating domains. However, the underlying principles by which chromatin architecture facilitates such adaptability across different cancers remain poorly understood. To investigate the role of chromatin in this process, we...
