30期

最新文章

• Sharks and rays have the oldest vertebrate sex chromosome with unique sex determination mechanisms AI翻译
  作者：Niwa, Taiki; Uno, Yoshinobu; Ohishi, Yuta; Kadota, Mitsutaka; Aburatani, Naotaka; Kiyatake, Itsuki; Katooka, Daiki; Yorozu, Michikazu; Tsuzuki, Nobutaka; Toyoda, Atsushi; Takagi, Wataru; Nakamura, Masaru; Kuraku, Shigehiro
  作者单位：Graduate University for Advanced Studies - Japan; Research Organization of Information & Systems (ROIS); National Institute of Genetics (NIG) - Japan; RIKEN; Tokushima University; Kobe University; University of Tokyo; Research Organization of Information & Systems (ROIS); National Institute of Genetics (NIG) - Japan; RIKEN; University of Michigan System; University of Michigan
  摘要：Sex determination has been investigated across vertebrate lineages to reveal the stepwise evolution of sex chromosomes and the diversity of responsible molecular mechanisms. However, these studies rarely include cartilaginous fishes, which diverged from the other vertebrates 450 Mya, hindering the comprehensive view of vertebrate sex determination. Here, we produced chromosome-scale genome assemblies of egg-laying shark species and comparatively investigated genome sequences and transcriptome ...
• Profile of Thomas Y. Hou AI翻译
  作者：Viegas, Jennifer
• Impact of women's political empowerment through gender quotas on improved drinking water access in Africa AI翻译
  作者：An, Jiafu; Wang, Tenghui; Chen, Bin; Gong, Peng; Lin, Chen; Stenseth, Nils Chr.
  作者单位：University of Hong Kong; Lingnan University; University of Hong Kong; University of Hong Kong; University of Hong Kong; Tsinghua University; University of Oslo; University of Oslo
  摘要：Access to safely managed drinking water is a fundamental human right, essential for human health and well- being. However, 2.2 billion people around the world still lack this access, with significant geographical disparities. In this study, we leveraged the implementation of gender quota laws-specifically reserved parliamentary seats for women across African countries-to examine its impact on improved water availability. Our findings reveal that the implementation of gender quotas is associate...
• Tensor-based quantum phase difference estimation for large-scale demonstration AI翻译
  作者：Kanno, Shu; Sugisaki, Kenji; Nakamura, Hajime; Yamauchi, Hiroshi; Sakuma, Rei; Kobayashi, Takao; Gao, Qi; Yamamoto, Naoki
  作者单位：Mitsubishi International Corporation (MIC); Mitsubishi Chemical Holdings Corporation; Mitsubishi Chemical; Keio University; Keio University; Keio University; SoftBank Corporation; JSR Corporation; Keio University
  摘要：We develop an energy calculation algorithm leveraging quantum phase difference estimation (QPDE) scheme and a tensor-network-based unitary compression method in the preparation of superposition states and time-evolution gates. Alongside its efficient implementation, this algorithm reduces depolarization noise affections exponentially. We demonstrated energy gap calculations for one-dimensional Hubbard models on IBM superconducting devices using circuits up to 32-system (plus oneancilla) qubits...
• Central memory T cells with key TCR repertoires and gene expression profiles dominate influenza CD8+T cell pools across the human lifespan AI翻译
  作者：Menon, Tejas; McQuilten, Hayley A.; Samir, Jerome; Nguyen, Thi H. O.; Lim, Ratana; Kaur, Jasveen; Rizzetto, Simone; Eltahla, Auda; Thomas, Paul G.; Lappas, Martha; Rossjohn, Jamie; Gras, Stephanie; Crowe, Jane; Flanagan, Katie L.; Luciani, Fabio; Doherty, Peter C.; van de Sandt, Carolien E.; Kedzierska, Katherine
  作者单位：University of Melbourne; Peter Doherty Institute; University of New South Wales Sydney; University of Melbourne; University of Tasmania; University of Tasmania; St Jude Children's Research Hospital; Monash University; Monash University; Cardiff University; La Trobe University; Royal Melbourne Institute of Technology (RMIT); Clifford Craig Foundation; Launceston General Hospital
  摘要：Central memory CD8+T cells (Tcm) represent the prominent memory T cell subset in human blood, yet the persistence of T cell receptor (TCR) clonotypic and transcriptional features of epitope-specific Tcm pools across the human lifespan remains unknown. We analyzed Tcm CD8+ T cells specific for HLA-A*02:01-M158-66 (A2/M158; a prominent influenza epitope) in newborns, children, adults, and older adults directly ex vivo. Our data provide evidence that epitope-specific Tcm CD8+ pools dominate influ...
• Ancient seabed checkerboard: How setae shaped spatial distributions of Silurian brachiopods AI翻译
  作者：Huang, Bing; Rong, Jiayu
  作者单位：Chinese Academy of Sciences; Nanjing Institute of Geology & Paleontology, CAS
  摘要：Understanding the drivers of spatial patterns in fossil communities is fundamental to paleoecology, yet direct evidence for biological mechanisms regulating interindividual spacing remains elusive. Brachiopod setae, hypothesized to function in feeding or defense, are exceedingly rare in the fossil record, especially among post-Cambrian taxa. Here, we present the report of exquisitely preserved setae from an exceptional in situ fossil assemblage of the early Silurian rhynchonelliform brachiopod...
• Epigenetic instability and hypofunctionality of fetal Tregs allow a permissive regulatory environment for T effector memory maturation AI翻译
  作者：Leong, Jing Yao; McGovern, Naomi; Mishra, Archita; Wasser, Martin; Kumar, Pavanish; Tay, Shi Huan; Hazirah, Sharifah Nur; Yeo, Joo Guan; Tan, Xiu Qi; Sutamam, Nursyuhadah; Azman, Farah Nadiah; Chua, Camillus Jian Hui; Chen, Phyllis ZiXuan; Ally, Fauziah; Dutertre, Charles- Antoine; Ramakrishna, Lakshmi; Poh, Su Li; Xie, Lian; Fan, Yiping; Donner, Catherine; Papadopoulou, Maria; Vermijlen, David; Arkachaisri, Thaschawee; Chan, Jerry Kok Yen; Ginhoux, Florent; Albani, Salvatore
  作者单位：University of Cambridge; Agency for Science Technology & Research (A*STAR); A*STAR - Singapore Immunology Network (SIgN); University of Sydney; KK Women's & Children's Hospital; UNICANCER; Gustave Roussy; Universite Paris Saclay; Institut National de la Sante et de la Recherche Medicale (Inserm); National University of Singapore; KK Women's & Children's Hospital; National University of Singapore; Universite Libre de Bruxelles; Universite Libre de Bruxelles; Universite Libre de Bruxelles
  摘要：The human gestational environment is commonly perceived to be predominantly suppressive and incompatible for T effector maturation. However, evidence of a competent effector fetal environment is mounting in the field. Here, we employed a high parametric, mass cytometry-based approach to study the fetal circulatory and microenvironmental immunomes, with the aim to understand the inception and extent of fetal effector T cell priming and its relation with regulatory mechanisms. We found evidence ...
• A preclinical pig model of Angelman syndrome mirrors the early developmental trajectory of the human condition AI翻译
  作者：Myers, Luke S.; Christian, Sarah G.; Simpson, Sean; Sper, Renan; Taylor, Clint; Montes, Laura; Jepp, Thomas B. C.; Ramos, Daniela; Schuller, Livia; Konganti, Kranti; Friedeck, Wade; Habib, Ozair; Hodge, McKaela; Taylor, Alasdair J.; Coffell, Ashley; Schlafer, Annalise; Matt, Morgan; Revell, Bradley; Knight, Carol; Barrena, Cristina C.; Murphy, William J.; Weeber, Edwin J.; Segal, David J.; Anderson, Anne; Nash, Kevin R.; Silvermanj, Jill L.; Piedrahita, Jorge A.; Dindot, Scott V.
  作者单位：Texas A&M University System; Texas A&M University College Station; University of Surrey; North Carolina State University; North Carolina State University; Texas A&M University System; Texas A&M University College Station; Texas A&M University System; Texas A&M University College Station; Texas A&M University System; Texas A&M University College Station; Texas A&M University System; Texas A&M University College Station; State University System of Florida; University of South Florida; University of California System; University of California Davis; University of California System; University of California Davis; Baylor College of Medicine; Baylor College of Medicine; University of California System; University of California Davis; Ultragenyx Pharmaceutical Inc.
  摘要：Angelman syndrome is a neurodevelopmental disorder characterized by severe motor and cognitive deficits. It is caused by the loss of the maternally inherited allele of the imprinted ubiquitin-protein ligase E3A (UBE3A) gene. Rodent models of Angelman syndrome do not fully recapitulate all the symptoms associated with the condition and are limited as a preclinical model for therapeutic development. Here, we show that pigs (Sus scrofa) with a maternally inherited deletion of UBE3A (UBE3A-/+) hav...
• Phage-based delivery of CRISPR-associated transposases for targeted bacterial editing AI翻译
  作者：Roberts, Avery; Adler, Benjamin A.; Cress, Brady F.; Doudna, Jennifer A.; Barrangou, Rodolphe
  作者单位：North Carolina State University; University of California System; University of California Berkeley
  摘要：Phage lambda, a well- characterized temperate phage, has been recently leveraged for bacterial genome editing by selectively delivering base editors into targeted bacterial species. We extend this concept by engineering phage lambda to deliver CRISPR- guided transposases, accomplishing large insertions and targeted gene disruptions. To achieve this, we engineered phage lambda using homologous recombination paired with Cas13a- based counterselection for precise phage modifications. Initially, w...
• Characterizing a highly excited and sustained brain response activity during gaming: P300-CE AI翻译
  作者：Pei, Leisi; Green, C. Shawn; Ouyang, Guang
  作者单位：University of Hong Kong; University of Wisconsin System; University of Wisconsin Madison
  摘要：Inspired by the high engagement and sustained behavioral excitement observed in video game players, we hypothesized that distinct brain activity patterns occur during gaming compared to a generic nongame setting. Using electroencephalography (EEG), we characterized the brain's response to critical in- game events, focusing on the response magnitude and adaptation. Data from a large participant cohort (n = 140 for game tasks, n = 200 for nongame tasks) revealed a clear, definite, and consistent...