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作者：Simka, Marian
作者单位：University of Opole
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作者：Liu, Liang; Tian, Changfu; Wang, Miaoxiao; Luo, Ying; Huang, Yaru; Jiang, Tingting; Zhao, Hongwen; Yu, Qijun; Wang, Entao; Yang, Jinshui; Yuan, Hongli
作者单位：China Agricultural University; China Agricultural University; China Agricultural University; Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss Federal Institutes of Technology Domain; Swiss Federal Institute of Aquatic Science & Technology (EAWAG); Instituto Politecnico Nacional - Mexico
摘要：Natural biopolymer-degrading microbial communities drive carbon biogeochemical cycling. Within these communities, polymer degraders facilitate the growth of non-degraders by breaking down polymers through extracellular enzymes. However, the contributions of nondegraders to community dynamics, as well as the mechanisms that limit their access to degradation products, remain poorly understood. Here, we investigate EMSD5, a lignocellulose-degrading microbial community that efficiently converts co...
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作者：Fratus, Marco; Alam, Muhammad A.
作者单位：Purdue University System; Purdue University
摘要：Since the 1960s, enzymatic sensors have been vital in healthcare and environmental monitoring due to their high selectivity. Traditionally, their performance is interpreted using the Michaelis-Menten (MM) equation, which assumes idealized, homogeneous, well-mixed laboratory conditions. However, integrating these sensors with microneedle (MN) patches for wearable applications introduces challenges such as spatial and temporal variations and limited reactant availability. Applying the MM model i...
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作者：Sun, Jingyao; Yu, Kailiang; Rietkerk, Max; Chen, Ning; Zhang, Hongxia; Song, Guang; Li, Xinrong
作者单位：Chinese Academy of Sciences; Chinese Academy of Sciences; Institute of Geographic Sciences & Natural Resources Research, CAS; Princeton University; Utrecht University; Lanzhou University; Lanzhou University; Xi'an University of Architecture & Technology; Northwest A&F University - China
摘要：Biota could be ecosystem engineers in generating an intrinsic heterogeneous landscape through scale- dependent feedbacks. Thereby, they can form resource- enriched patchiness or islands of fertility, comprising self- organizing spatial patterns. Research so far has largely focused on the self- organized spatial patterns of plant communities in drylands. It, however, remains unclear whether and how biocrusts having distinct morphology and life history from plant communities could self- organize...
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作者：Bolik-Coulon, Nicolas; Rossler, Philip; Nosella, Michael L.; Kim, Tae Hun; Kay, Lewis E.
作者单位：University of Toronto; University of Toronto; University of Toronto; University of Toronto; Hospital for Sick Children (SickKids); University of Colorado System; University of Colorado Boulder; University System of Ohio; Case Western Reserve University
摘要：Cellular DNA is wrapped about an octamer composed of four histone proteins forming intrinsically disordered tails of the histones serve as scaffolds for binding an array of proteins that regulate the fidelity of the genome and gene expression. A variety of posttranslational modifications (PTMs) on the tails have been characterized, including some that alter their overall charge; however, per- residue changes in tail electrostatic potentials for different PTMs have not been reported. Here, usin...
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作者：Huang, Bing; Rong, Jiayu
作者单位：Chinese Academy of Sciences
摘要：Understanding the drivers of spatial patterns in fossil communities is fundamental to paleoecology, yet direct evidence for biological mechanisms regulating interindividual spacing remains elusive. Brachiopod setae, hypothesized to function in feeding or defense, are exceedingly rare in the fossil record, especially among post-Cambrian taxa. Here, we present the report of exquisitely preserved setae from an exceptional in situ fossil assemblage of the early Silurian rhynchonelliform brachiopod...
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作者：Leong, Jing Yao; McGovern, Naomi; Mishra, Archita; Wasser, Martin; Kumar, Pavanish; Tay, Shi Huan; Hazirah, Sharifah Nur; Yeo, Joo Guan; Tan, Xiu Qi; Sutamam, Nursyuhadah; Azman, Farah Nadiah; Chua, Camillus Jian Hui; Chen, Phyllis ZiXuan; Ally, Fauziah; Dutertre, Charles- Antoine; Ramakrishna, Lakshmi; Poh, Su Li; Xie, Lian; Fan, Yiping; Donner, Catherine; Papadopoulou, Maria; Vermijlen, David; Arkachaisri, Thaschawee; Chan, Jerry Kok Yen; Ginhoux, Florent; Albani, Salvatore
作者单位：University of Cambridge; Agency for Science Technology & Research (A*STAR); A*STAR - Singapore Immunology Network (SIgN); University of Sydney; KK Women's & Children's Hospital; UNICANCER; Gustave Roussy; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Saclay; National University of Singapore; KK Women's & Children's Hospital; National University of Singapore; Universite Libre de Bruxelles; Universite Libre de Bruxelles; Universite Libre de Bruxelles
摘要：The human gestational environment is commonly perceived to be predominantly suppressive and incompatible for T effector maturation. However, evidence of a competent effector fetal environment is mounting in the field. Here, we employed a high parametric, mass cytometry-based approach to study the fetal circulatory and microenvironmental immunomes, with the aim to understand the inception and extent of fetal effector T cell priming and its relation with regulatory mechanisms. We found evidence ...
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作者：Myers, Luke S.; Christian, Sarah G.; Simpson, Sean; Sper, Renan; Taylor, Clint; Montes, Laura; Jepp, Thomas B. C.; Ramos, Daniela; Schuller, Livia; Konganti, Kranti; Friedeck, Wade; Habib, Ozair; Hodge, McKaela; Taylor, Alasdair J.; Coffell, Ashley; Schlafer, Annalise; Matt, Morgan; Revell, Bradley; Knight, Carol; Barrena, Cristina C.; Murphy, William J.; Weeber, Edwin J.; Segal, David J.; Anderson, Anne; Nash, Kevin R.; Silvermanj, Jill L.; Piedrahita, Jorge A.; Dindot, Scott V.
作者单位：Texas A&M University System; Texas A&M University College Station; University of Surrey; North Carolina State University; North Carolina State University; Texas A&M University System; Texas A&M University College Station; Texas A&M University System; Texas A&M University College Station; Texas A&M University System; Texas A&M University College Station; Texas A&M University System; Texas A&M University College Station; State University System of Florida; University of South Florida; University of California System; University of California Davis; University of California System; University of California Davis; Baylor College of Medicine; Baylor College of Medicine; University of California System; University of California Davis; Ultragenyx Pharmaceutical Inc.
摘要：Angelman syndrome is a neurodevelopmental disorder characterized by severe motor and cognitive deficits. It is caused by the loss of the maternally inherited allele of the imprinted ubiquitin-protein ligase E3A (UBE3A) gene. Rodent models of Angelman syndrome do not fully recapitulate all the symptoms associated with the condition and are limited as a preclinical model for therapeutic development. Here, we show that pigs (Sus scrofa) with a maternally inherited deletion of UBE3A (UBE3A-/+) hav...
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作者：Roberts, Avery; Adler, Benjamin A.; Cress, Brady F.; Doudna, Jennifer A.; Barrangou, Rodolphe
作者单位：North Carolina State University; University of California System; University of California Berkeley
摘要：Phage lambda, a well- characterized temperate phage, has been recently leveraged for bacterial genome editing by selectively delivering base editors into targeted bacterial species. We extend this concept by engineering phage lambda to deliver CRISPR- guided transposases, accomplishing large insertions and targeted gene disruptions. To achieve this, we engineered phage lambda using homologous recombination paired with Cas13a- based counterselection for precise phage modifications. Initially, w...
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作者：Goswami, Srikanta; Dhar, Gunjan; Mukherjee, Saikat; Mahata, Bidesh; Chatterjee, Saibal; Home, Pratik; Adhya, Samit
