30期

最新文章

• Threonine phosphorylation of STAT1 safeguards gut epithelial and restricts interferon-mediated AI翻译
  作者：Metwally, Hozaifa; Elbrashy, Maha M.; Kayama, Hisako; Okuyama, Kazuki; Taniuchi, Ichiro; Takeda, Kiyoshi; Kishimoto, Tadamitsu
  作者单位：University of Osaka; Egyptian Knowledge Bank (EKB); National Research Centre (NRC); University of Osaka; University of Osaka; RIKEN
  摘要：Barrier tissues such as the intestine are constantly challenged by environmental stressors and must adapt to maintain integrity and prevent excessive inflammation. Although traditionally viewed as a proinflammatory effector of interferon (IFN) signaling, STAT1 is shown here to play a protective role in intestinal epithelial cells (IEC) by promoting resilience to damage and restraining IFN- induced cytotoxicity. We identify phosphorylation of threonine 748 (Thr748) on STAT1 as an evolutionarily...
• A multifunctional anti-O-Antigen human monoclonal antibody protects against Shigella sonnei infection in vivo AI翻译
  作者：Ridelfi, Matteo; Vezzani, Giacomo; Roscioli, Emanuele; Batani, Giampiero; Boero, Elena; Nannini, Francesco; Marini, Eleonora; Bhaumik, Ushasi; Desalegn, Girmay; Serpino, Ornella; Molinaro, Antonio; Paciello, Ida; Mugnaini, Chiara; De Santi, Concetta; Maccari, Giuseppe; De Rosa, Antonella; Valensin, Silvia; Duatti, Assia; Di Benedetto, Roberta; Raso, Maria Michelina; Alfini, Renzo; Sammicheli, Chiara; Tavarini, Simona; Quigley, Christina; Podda, Audino; Kabanova, Anna; Andreano, Emanuele; Cardamone, Dario; Gasperini, Gianmarco; Necchi, Francesca; Pizza, Mariagrazia; Martin, Laura B.; Frenck Jr, Robert W.; Grassart, Alexandre; Silipo, Alba; Pasetti, Marcela F.; Scorza, Francesco Berlanda; Giannelli, Carlo; Rossi, Omar; Micoli, Francesca; Sala, Claudia; Rappuoli, Rino
  作者单位：University of Siena; GlaxoSmithKline; University System of Maryland; University of Maryland Baltimore; University of Naples Federico II; GlaxoSmithKline; Cincinnati Children's Hospital Medical Center; University System of Ohio; University of Cincinnati; Pasteur Network; Universite de Lille; Institut Pasteur Lille; Imperial College London; United States Pharmacopeia (USP)
  摘要：Shigellosis is a global public health challenge that mostly affects low-and middle-income countries and causes considerable morbidity and mortality among children under 5 y of age. Multi-and extensively drug-resistant Shigella sonnei strains associated with recent outbreaks in high-income countries exacerbate the problem and have prompted the World Health Organization to include Shigella spp. among the high-risk pathogens for which novel prophylactic and therapeutic tools are urgently needed. ...
• Thioether editing generally increases the photostability of rhodamine dyes on self-labeling tags AI翻译
  作者：Ling, Jing; Zhang, Yuan; Hei, Yongzhen; Kompa, Julian; Yang, Chen; Wang, Bo; Zhang, Junwei; Du, Jiasheng; Rudi, Tatjana; Zhang, Kecheng; Sun, Jingfu; Wang, Wenjuan; Fabritz, Sebastian; Li, Yulong; Deng, Wulan; Zou, Peng; Chen, Chunlai; Chen, Zhixing
  作者单位：Peking University; Peking University; Tsinghua University; Max Planck Society; Peking University; Peking University; Max Planck Society; Tsinghua University; Peking University; Peking University; Chinese Institute for Brain Research, Beijing; Peking University; Chinese Academy of Sciences
  摘要：Self- labeling protein tags are widely used in advanced bioimaging where dyes with high- photon budgets outperform their fluorescent protein counterparts. Further increasing the emitted photon numbers of dye- tag systems is actively pursued by both new fluorophore chemistry and protein engineering. By scrutinizing the protein microenvironment of fluorophores, here we propose that proximal thioether groups negatively affect the photostability of the dye- tag system. We attribute the disparity i...
• Nucleation at solid-liquid interfaces is accompanied by the reconfiguration of electrical double layers AI翻译
  作者：Ai, Qian; Bonagiri, Lalith Krishna Samanth; Panse, Kaustubh S.; Kim, Jaehyeon; Zhou, Shan; Zhang, Yingjie; Cui, Yi
  作者单位：University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign
  摘要：In electrochemical systems, the structure of electrical double layers (EDLs) near electrode surfaces is crucial for energy conversion and storage functions. While the electrodes in real-world systems are usually heterogeneous, to date the investigation of EDLs is mainly limited to planar, homogeneous substrates. To bridge this gap, here we image the EDL structure of an ionic liquid/graphite battery anode system in the initial stage of interfacial nucleation and growth using our recently develo...
• eIF4A controls translation of estrogen receptor alpha and is a therapeutic target in advanced breast cancer AI翻译
  作者：Boyer, Jacob A.; Rosen, Ezra Y.; Sharma, Malvika; Dorso, Madeline A.; Mai, Nicholas; Amor, Corina; Reiter, Jason M.; Kannan, Ram; Gadal, Sunyana; Xu, Jianing; Miele, Matthew; Li, Zhuoning; Chen, Xiaoping; Chang, Qing; Pareja, Fresia; Worland, Stephan; Warner, Douglas; Sperry, Sam; Chiang, Gary G.; Thompson, Peggy A.; Yang, Guangli; Ouerfelli, Ouathek; Drilon, Alexander; de Stanchina, Elisa; Wendel, Hans- Guido; Chandarlapaty, Sarat; Rosen, Neal
  作者单位：Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Ludwig Institute for Cancer Research; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; Cornell University; Weill Cornell Medicine
  摘要：Most breast cancers depend on hormone-stimulated estrogen receptor alpha (ER) activity and are sensitive to ER inhibition. Resistance can arise from activating mutations in the gene encoding ER (ESR1) or from reactivation of downstream targets. Newer ER antagonists occasionally show efficacy but are largely ineffective as single agents in the long term. Here, we show that ER translation is eIF4E/cap-independent yet sensitive to inhibitors of the translation initiation factor eIF4A. EIF4A inhib...
• Bivalent interaction through an intrinsically disordered linker promotes transcription activation complex assembly in Notch signaling AI翻译
  作者：Cook, Cyril; Ramsey, Kristen M.; Barrick, Doug
  作者单位：Johns Hopkins University; University of Connecticut
  摘要：The Notch signaling pathway regulates cellular differentiation by activating transcription through an unusual heterotrimeric complex comprising the Notch receptor's intracellular domain (NICD), the DNA-binding protein CSL, and the coactivator MAML. NICD has two binding sites for CSL, a short motif in the RAM region and an ankyrin domain (ANK), connected by an intrinsically disordered linker and which form a bivalent ternary complex with CSL and MAML. Although bivalency is required for maximal ...
• Thermal mismatch models derived from occurrence data predict pathogen prevalence in frogs AI翻译
  作者：Duncan, Richard P.; Scheele, Ben C.; Clulow, Simon
  作者单位：University of Canberra; Australian National University
  摘要：Emerging infectious diseases increasingly threaten many wildlife populations, yet the impacts of pathogens vary considerably both within and among host species. The environmental tolerance mismatch hypothesis (ETMH) suggests that this variability stems in part from differences in the relative performance of hosts and pathogens under varying environmental conditions. According to the ETMH, pathogen impacts should be more severe in environments where pathogen performance is high and host perform...
• Cell type-specific purifying selection of synonymous mitochondrial DNA variation AI翻译
  作者：Lareau, Caleb A.; Maschmeyer, Patrick; Yin, Yajie; Gutierrez, Jacob C.; Dhindsa, Ryan S.; Burrer, Anne - Sophie Gribling -; Zielinski, Sebastian; Hsieh, Yu - Hsin; Nitsch, Lena; Dimitrova, Veronika; Nalbant, Benan; Buquicchio, Frank A.; Abay, Tsion; Stickels, Robert R.; Ulirsch, Jacob C.; Yan, Patrick; Wang, Fangyi; Miao, Zhuang; Sandor, Katalin; Daniel, Bence; Liu, Vincent; Mendez, Paul L.; Knaus, Petra; Meyer, Manpreet; Greenleaf, William J.; Kundaje, Anshul; Smyth, Redmond P.; Munschauer, Mathias; Ludwig, Leif S.; Satpathy, Ansuman T.
  作者单位：Memorial Sloan Kettering Cancer Center; Stanford University; Humboldt University of Berlin; Free University of Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health; Helmholtz Association; Max Delbruck Center for Molecular Medicine; Baylor College of Medicine; Baylor College of Medicine; Baylor College Medical Hospital; Baylor College of Medicine; Helmholtz Association; Helmholtz-Center for Infection Research; Free University of Berlin; Harvard University; Harvard Medical School; Stanford University; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard Medical School; Stanford University; Ruprecht Karls University Heidelberg
  摘要：While somatic variants are well-characterized drivers of tumor evolution, their influence on cellular fitness in nonmalignant contexts remains understudied. We identified a mosaic synonymous variant (m.7076A > G) in the mitochondrial DNA (mtDNA)-encoded cytochrome c-oxidase subunit 1 (MT-CO1, p.Gly391=), present at homoplasmy in 47% of immune cells from a healthy donor. Single-cell multiomics revealed strong, lineage-specific selection against the m.7076G allele in CD8+ effector memory T cells...
• Human land use promotes range expansion of soil protists from temperate to subtropical regions in China AI翻译
  作者：Li, Zhi-Peng; Sun, Xin; Yao, Haifeng; Shangguan, Hua-Yuan; Hu, Hang-Wei; Tang, Zhiyao; Li, Gang; Zhang, Weixin; Delgado-Baquerizo, Manuel; Scheu, Stefan; Zhu, Yong-Guan
  作者单位：Chinese Academy of Sciences; Institute of Urban Environment, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; University of Melbourne; Peking University; Peking University; Henan University; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto de Recursos Naturales y Agrobiologia de Sevilla (IRNAS); University of Gottingen; University of Gottingen
  摘要：Land- use changes are reshaping the distribution of aboveground species worldwide. However, the impact of land- use changes on the distribution of soil organisms remains poorly understood. In particular, we lack a mechanistic understanding of the environmental factors reshaping the distribution of soil microbiota in response to global biological homogenization. Here, we used metabarcoding to investigate the biogeography of protists and their relationships with prey and hosts in three human- do...
• Hydrogen cyanide and hydrocarbons mix on Titan AI翻译
  作者：Izquierdo-Ruiz, Fernando; Cable, Morgan L.; Hodyss, Robert; Vu, Tuan H.; Sandstrom, Hilda; Lobato, Alvaro; Rahm, Martin
  作者单位：Chalmers University of Technology; Complutense University of Madrid; National Aeronautics & Space Administration (NASA); NASA Jet Propulsion Laboratory (JPL); California Institute of Technology
  摘要：This work reveals a striking exception to the well-established rule in chemistry that polar and nonpolar compounds do not spontaneously mix: insertion of methane, ethane, and other small hydrocarbons into the crystal lattice of hydrogen cyanide (HCN), a highly polar molecule. By mixing these components at cryogenic temperatures, we can observe distinct shifts in vibrational modes using Raman spectroscopy. Our computational predictions confirm that cocrystal structures of HCN and ethane, which ...