30期

最新文章

• Kinetic pathways of solid-solid phase transitions dictated by short-range interactions AI翻译
  作者：Pan, Hillary; Dshemuchadse, Julia
  作者单位：Cornell University
  摘要：Structural phase transformations allow us to design materials from the ground up. Predicting the structural transformation of crystals during solid-solid phase transitions, however, is challenging, as the transition can proceed through multiple pathways that are difficult to probe experimentally. Using minimal computational models, we show that distinct kinetic pathways between body-centered cubic (bcc) and face-centered cubic (fcc) crystal structures can be encoded into a system by specific p...
• Structure reveals a regulation mechanism of plant outward-rectifying K+ channel CORK by structural rearrangements in the CNBD-Ankyrin bridge AI翻译
  作者：Yamanashi, Taro; Muraoka, Yuki; Furuta, Tadaomi; Kume, Tsukasa; Sekido, Natsuko; Saito, Shunya; Terashima, Shota; Yokoyama, Takeshi; Tanaka, Yoshikazu; Miyamoto, Atsushi; Sato, Kanane; Ito, Tomoyuki; Nakazawa, Hikaru; Umetsu, Mitsuo; Tanudjaja, Ellen; Tsujii, Masaru; Dreyer, Ingo; Schroeder, Julian I.; Ishimaru, Yasuhiro; Uozumi, Nobuyuki
  作者单位：Tohoku University; Tohoku University; Universidad de Talca; University of California System; University of California San Diego
  摘要：Guard cells, which regulate stomatal apertures in plants, possess a sophisticated mechanism for regulating turgor pressure. The outward- rectifying K+out channel GORK, expressed in guard cells of the plant Arabidopsis thaliana, is a central component that promotes stomatal closure by releasing K+ to the extracellular space, thereby lowering turgor pressure. To date, the structural basis underlying the regulation of the K+ transport activity of GORK is unclear. Using cryo- EM, we determined the...
• The kinesin KIF3AC recycles endocytosed integrin to polarize new adhesion formation toward the leading edge AI翻译
  作者：Rockenbach, Johnny A. Z.; Nader, Guilherme P. F.; Antoku, Susumu; Gundersen, Gregg G.
  作者单位：Columbia University; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia
  摘要：The recycling of integrin endocytosed during focal adhesion (FA) disassembly is critical for cell migration and contributes to the polarized formation of new FAs toward the leading edge. How this occurs is unclear. Here, we sought to identify the kinesin motor protein(s) that is involved in recycling endocytosed integrin back to the plasma membrane. We show that the kinesin- 2 heterodimer, KIF3AC, and the Rab11 adaptor protein Rab coupling protein (RCP) are required for FA reformation after th...
• Sound- evoked tonic motility of cochlear outer hair cells in mice with stereociliary defects AI翻译
  作者：Dewey, James B.
  作者单位：University of Southern California
  摘要：Mammalian hearing sensitivity depends on the amplification of sound-induced cochlear vibrations by outer hair cells (OHCs). OHCs transduce deflections of their stereociliary bundles into receptor potentials that drive changes in cell length. While fast, phasic OHC length changes are thought to generate the forces that underlie cochlear amplification, OHCs also exhibit large tonic length changes in response to sound. These tonic length changes could theoretically arise from asymmetries in the m...
• Optimal kinetics for catalytic cycles from a single path-sampling simulation AI翻译
  作者：Bolhuis, Peter G.
  作者单位：University of Amsterdam
  摘要：A catalyst's efficiency for accelerating a reaction rate is determined by its molecular structure and interactions with the substrate. While one can predict kinetics for a particular molecular model, tuning the (potentially many) model parameters to reach a desired or optimal kinetics for a catalytic cycle is usually considered computationally prohibitively expensive, especially in solvated systems. Here, we show for a simple model representing a minimal catalytic cycle that such optimization ...
• Stress- induced translocation of the endoplasmic reticulum chaperone GRP78/BiP and its impact on human disease and therapy AI翻译
  作者：Lee, Amy S.
  作者单位：University of Southern California; University of Southern California
  摘要：Since their discoveries in the 1960s as a family of proteins produced by cells in response to stress, molecular chaperones are increasingly recognized as major regulators of cellular homeostasis in health and disease. Among the heat shock protein 70 family, the 78-kDa glucose-regulated protein (GRP78), also referred to as BiP and encoded by the HSPA5 gene, contains a signal peptide targeting it into the endoplasmic reticulum (ER). Through its interaction with the transmembrane ER stress sensor...
• Mechanistic insights into the iron-sulfur cluster- dependent interaction of the autophagy receptor NCOA4 with the E3 ligase HERC2 AI翻译
  作者：Liu, Haobo; Shen, Liqiang; Gong, Xinyu; Zhou, Xindi; Huang, Yichao; Zhou, Yuqian; Guo, Zhenpeng; Guo, Hanbo; Wang, Shichao; Pan, Lifeng
  作者单位：Chinese Academy of Sciences; Shanghai Institute of Organic Chemistry, CAS; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
  摘要：NCOA4, a dedicated autophagy receptor for mediating selective autophagy of ferritin (ferritinophagy), plays a vital role in maintaining cellular iron homeostasis. The cellular abundance of NCOA4 is regulated by the E3 ligase HERC2 that can specifically tar- get NCOA4 for proteasomal degradation under iron-- replete conditions. However, the detailed molecular mechanism governing the iron-- dependent recognition of NCOA4 by HERC2 remains elusive. Here, using multidisciplinary approaches, we syst...
• Soil nitrogen drives inverse acclimation of xylem growth cessation to rising temperature in Northern Hemisphere conifers AI翻译
  作者：Zhang, Yaling; Huang, Jian- Guo; Wang, Minhuang; Wang, Wenjin; Yang, Feiyu; Deslauriers, Annie; Fonti, Patrick; Liang, Eryuan; Maekinen, Harri; Oberhuber, Walter; Rathgeber, Cyrille B. K.; Tognetti, Roberto; Treml, Vaclav; Yang, Bao; Zhai, Lihong; Antonucci, Serena; Butto, Valentina; Camarero, J. Julio; Campelo, Filipe; Cufar, Katarina; De Luis, Martin; Fajstavr, Marek; Giovannelli, Alessio; Gricar, Jozica; Gruber, Andreas; Gryc, Vladimir; Gueney, Aylin; Jyske, Tuula; Kaspar, Jakub; King, Gregory; Krause, Cornelia; Lemay, Audrey; Lombard, Fabio; Castillo, Edurne Martinez del; Morin, Hubert; Nabais, Cristina; Noejd, Pekka; Peters, Richard L.; Prislan, Peter; Saracinoa, Antonio; V. Shishovbb, Vladimir; Vavrciks, Hanus; Vieirac, Joana; Zengd, Qiao; Rossi, Sergio
  作者单位：Chinese Academy of Sciences; South China Botanical Garden, CAS; Zhejiang University; Guangdong Academy of Sciences; Institute of Eco-environmental & Soil Sciences, Guangdong Academy of Sciences; University of Quebec; University of Quebec Chicoutimi; Swiss Federal Institutes of Technology Domain; Swiss Federal Institute for Forest, Snow & Landscape Research; Chinese Academy of Sciences; Institute of Tibetan Plateau Research, CAS; Natural Resources Institute Finland (Luke); University of Innsbruck; Universite de Lorraine; AgroParisTech; Free University of Bozen-Bolzano; Charles University Prague; Nanjing University; University of Molise; University of Quebec; University Quebec Abitibi-Temiscamingue; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto Pirenaico de Ecologia (IPE); Universidade de Coimbra; University of Ljubljana; Johannes Gutenberg University of Mainz; Mendel University in Brno; Slovenian Forestry Institute; Izmir Katip Celebi University; University of Alberta; Universita Mediterranea di Reggio Calabria; Technical University of Munich; University of Naples Federico II; Siberian Federal University; Guangdong Academy of Sciences; Guangzhou Institute of Geography, Guangdong Academy of Sciences
  摘要：Controlled experiments suggest that the seasonal build-up of nitrogen (N) limitation constrains the responses of forest autumn phenology to elevated temperatures. Therefore, rising soil N is expected to increase the delaying effects of elevated temperature on the end of the season, i.e., leaf senescence. However, the interactive effects of temperature, soil N, and aridity on xylem autumn phenology remain unknown. We conducted a wide spatial analysis from 75 conifer sites in the Northern Hemisp...
• An electron- bifurcating plug to a protein nanowire in tungsten- dependent aldehyde detoxification AI翻译
  作者：Feng, Xiang; Schut, Gerrit J.; Putumbaka, Saisuki; Li, Huilin; Adams, Michael W. W.
  作者单位：Van Andel Institute; University System of Georgia; University of Georgia; California Institute of Technology
  摘要：Members of the tungsten-containing oxidoreductase (WOR) family, which contain a tungstopyranopterin (Tuco) cofactor, are typically either monomeric (WorL) or heterodimeric (WorLS). These enzymes oxidize aldehydes to the corresponding acids while reducing the redox protein ferredoxin. They have been structurally characterized mainly using WORs from hyperthermophilic archaea. The WORs of some bacteria contain three additional subunits of the BfuABC family and these chimeric WorABCSL enzymes cata...
• Subunit specialization in AAA+ proteins and substrate unfolding during transcription complex remodeling (vol 122, e2425868122, 2025) AI翻译
  作者：Gao, Forson; Ye, Fuzhou; Jovanovic, Milija; Buck, Martin; Zhang, Xiaodong
  作者单位：Imperial College London; Imperial College London; University of Belgrade; Francis Crick Institute