34期

最新文章

• Inbreeding reduces fitness in spatially structured populations of a threatened rattlesnake AI翻译
  作者：Clark, Meaghan I.; Hileman, Eric T.; Moore, Jennifer A.; Faust, Lisa J.; Junge, Randall E.; Reid, Brendan N.; Bradke, Danielle R.; Bradburd, Gideon S.; Fitzpatrick, Sarah W.
  作者单位：Michigan State University; Michigan State University; Michigan State University; University of California System; University of California Santa Cruz; West Virginia University; Grand Valley State University; Rutgers University System; Rutgers University New Brunswick; University of Namur; University System of Georgia; University of Georgia; University of Michigan System; University of Michigan
  摘要：Small and fragmented populations are at high risk of local extinction, in part because of elevated inbreeding and subsequent inbreeding depression. A major conservation priority is to identify the mechanisms and extent of inbreeding depression in small populations. The eastern massasauga (Sistrurus catenatus) rattlesnake is listed as Federally Threatened in the United States, having experienced significant habitat fragmentation and concomitant population declines over the past 200 years. Here,...
• Laser- emitting aqueous bioreactors for ultrasensitive bioactivity analysis AI翻译
  作者：Fang, Guocheng; Tseng, Po- Hao; Liao, Jie; Zhu, Song; Zhou, Tian; Liu, Hangrui; Zhu, Hui; Jin, Dayong; Yang, Lan; Chen, Yu-Cheng
  作者单位：University of Technology Sydney; Nanyang Technological University; Washington University (WUSTL); University of California System; University of California San Francisco; University of Technology Sydney
  摘要：Water droplets, acting as natural bioreactors and optical whispering- gallery- mode ous droplet lasers can only survive in air with a limited lifespan (<100 s) due to rapid evaporation, restricting their applications in bioreactions. To address this challenge, we introduce laser- emitting aqueous bioreactors (LEABs) in fluorocarbon oils. These LEABs enable stable laser emission and extend a droplet lifespan over 1,000- fold. LEABs enable the encapsulation of bioactive materials for long- term ...
• G- quadruplex stabilization induces DNA breaks in pericentromeric repetitive DNA sequences in B lymphocytes AI翻译
  作者：Waisertreiger, Irina; Ayele, Kalkidan; Elshaikh, Mehad Hilal; Barlow, Jacqueline H.
  作者单位：University of California System; University of California Davis
  摘要：DNA secondary G-quadruplex (G4) structures can impair and even obstruct DNA replication. Defects in processing G4 structures are associated with replication stress, a common property of both B cell cancers and hyperproliferative premalignant cells. Genome instability arising from replication stress is a hallmark of cancer and strongly contributes to the chromosome rearrangements in B cell cancers. Here, we define the impact of G4-stabilizing ligands on generating genome instability in primary ...
• Solstice, selection, and synchrony of seed masting AI翻译
  作者：Bogdziewicz, Michal; Hacket-Pain, Andrew; Kelly, Dave; Szymkowiak, Jakub; Foest, Jessie; Journe, Valentin
  作者单位：Adam Mickiewicz University; University of Liverpool; University of Canterbury; Adam Mickiewicz University; Kyushu University
• Object-directed action representations are componentially built in parietal cortex AI翻译
  作者：Caglar, Leyla Roksan; Walbrin, Jon; Akwayena, Emefa; Almeida, Jorge; Mahon, Bradford Z.
  作者单位：Carnegie Mellon University; Universidade de Coimbra; Universidade de Coimbra; Carnegie Mellon University; University of Rochester
  摘要：The inferior parietal lobule supports action representations that are necessary to grasp and 71-78 (2004)]. The supramarginal gyrus (SMG) is a structure within the inferior parietal lobule that specifically processes object-directed patterns of manipulation during functional object use. Here, we demonstrate that neural representations of complex object-directed actions in the SMG can be predicted by a linear encoding model that componentially builds complex actions from an empirically defined ...
• Synaptic transmission is dispensable for selecting the winner input but is crucial for the subsequent events of synapse elimination AI翻译
  作者：Kao, Tzu- Huei; Okuno, Yuto; Matsuyama, Kyoko; Watanabe, Takaki; Uesaka, Naofumi; Kano, Masanobu
  作者单位：University of Tokyo; University of Tokyo; Teikyo University; Institute of Science Tokyo
  摘要：Synaptic transmission has long been thought to regulate neuronal wiring during postnatal development, but this assumption remains largely untested. Selective strengthening of a single winner climbing fiber (CF) afferent to each Purkinje cell (PC) and elimination of the other loser CF axons in the cerebellum has been a representative model of neural circuit refinement. Here, we examined the role of neurotransmission at CF-PC synapses in their postnatal development. We labeled a subset of CFs in...
• RyR1-mediated Ca2+- induced Ca2+release plays a negligible role in excitation-contraction coupling of normal skeletal muscle AI翻译
  作者：Kobayashi, Takuya; Yamazawa, Toshiko; Kurebayashi, Nagomi; Konishi, Masato; Tanihata, Jun; Sugihara, Masami; Miki, Yoshifumi; Noguchi, Satoru; Inoue, Yukiko U.; Inoue, Takayoshi; Sakurai, Takashi; Murayama, Takashi
  作者单位：Jikei University; Juntendo University; Jikei University; Jikei University; Jikei University; Juntendo University; National Center for Neurology & Psychiatry - Japan; National Center for Neurology & Psychiatry - Japan
  摘要：Type 1 ryanodine receptor (RyR1) is a Ca2+ release channel in the sarcoplasmic reticulum in skeletal muscle. In excitation-contraction (E-C) coupling, RyR1 opens by depolarization of transverse tubule membrane via physical interaction with dihydropyridine receptor, which is referred to as depolarization-induced Ca2+ release (DICR). RyR1 can also be gated via Ca2+-induced Ca2+ release (CICR), in which binding of Ca2+ directly opens the channel. Thus, RyR1 has two Ca2+ release modes; DICR and CI...
• Identification of broadly inhibitory anti-PfEMP1 antibodies by mass spectrometry sequencing of plasma IgG from a malaria- exposed child AI翻译
  作者：Turner, Louise; Diaz, Teresa Nunez de Villavicencio; Raghavan, Sai Sundar Rajan; Kana, Ikhlaq Hussain; Lyimo, Eric; Reitzel, Chelsea; Wang, Christian W.; Berube, Ewen; Jensen, Rasmus W.; Loeffler, Johannes R.; Fernandez, Monica Lisa; Theander, Thor G.; Lusingu, John P. A.; Le Bihan, Thierry; Han, Xiaobing; Minja, Daniel T. R.; Ward, Andrew B.; Ma, Bin; Lavstsen, Thomas
  作者单位：University of Copenhagen; University of Copenhagen; Copenhagen University Hospital; Rigshospitalet; Scripps Research Institute
  摘要：Plasmodium falciparum pathology is driven by the accumulation of parasite- infected erythrocytes in blood capillaries. This sequestration process is mediated by the parasite's P. falciparum erythrocyte membrane protein 1 (PfEMP1) adhesins, which bind select endothelial cell receptors. A subset of PfEMP1 binding human endothelial protein C receptor (EPCR) through their cysteine- rich interdomain region alpha 1 (CIDR alpha 1) domains drives the pathogenesis to severe malaria. Despite high sequen...
• ER-resident CCDC134 safeguards TLR4 maturation by maintaining gp96 stability AI翻译
  作者：Bai, Yang; Zhang, Chao; Liu, Hao; Deng, Fan; Wu, Zeyu; Deng, Wanyan; Zheng, Zengzhang; Min, Rui; Mei, Shenglin; Kang, He; Yu, Huiqing; Pan, Youdong; Lieberman, Judy; Zhao, Jingxia; Liu, Xing
  作者单位：Chinese Academy of Sciences; Shanghai Institute of Immunity and Infection, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chongqing Medical University; Tongji University; Virginia Polytechnic Institute & State University; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Program in Cellular & Molecular Medicine (PCMM); Harvard University; Harvard Medical School; Capital Medical University
  摘要：Toll-like receptor 4 (TLR4), a pattern-recognition receptor located on the plasma membrane, senses extracellular danger signals to initiate inflammatory immune responses. It is initially synthesized in the endoplasmic reticulum (ER), undergoes N-linked glycosylation, and is subsequently transported to the Golgi before ultimately reaching the plasma membrane. However, the mechanisms underlying the processing and maturation of TLR4 in the ER remain elusive. Through whole genome-wide CRISPR scree...
• Aspartic acid residues in BBE- like enzymes from Morus alba promote a function shift from oxidative cyclization to dehydrogenation AI翻译
  作者：Guo, Nianxin; Gu, Jun; Zhou, Qingyang; Liu, Fang; Dong, Haoran; Ding, Qi; Wang, Qixuan; Wu, Dongshan; Yang, Jun; Fan, Junping; Gao, Lei; Houk, Kendall N.; Lei, Xiaoguang
  作者单位：Peking University; Peking University; Chinese Academy of Sciences; Peking University; Nanjing University of Science & Technology; University of California System; University of California Los Angeles; Nanjing Agricultural University; Wuhan University
  摘要：Berberine bridge enzyme (BBE)-like enzymes catalyze various oxidative cyclization and dehydrogenation reactions in natural product biosynthesis, but the molecular mechanism underlying the selectivity remains unknown. Here, we elucidated the catalytic mechanism of BBE-like oxidases from Morus alba involved in the oxidative cyclization and dehydrogenation of moracin C. X-ray crystal structures of a functionally promiscuous flavin adenine dinucleotide (FAD)-bound oxidase, MaDS1, with and without ...