34期

最新文章

• Aspartic acid residues in BBE- like enzymes from Morus alba promote a function shift from oxidative cyclization to dehydrogenation AI翻译
  作者：Guo, Nianxin; Gu, Jun; Zhou, Qingyang; Liu, Fang; Dong, Haoran; Ding, Qi; Wang, Qixuan; Wu, Dongshan; Yang, Jun; Fan, Junping; Gao, Lei; Houk, Kendall N.; Lei, Xiaoguang
  作者单位：Peking University; Chinese Academy of Sciences; Peking University; Peking University; Nanjing University of Science & Technology; University of California System; University of California Los Angeles; Nanjing Agricultural University; Wuhan University
  摘要：Berberine bridge enzyme (BBE)-like enzymes catalyze various oxidative cyclization and dehydrogenation reactions in natural product biosynthesis, but the molecular mechanism underlying the selectivity remains unknown. Here, we elucidated the catalytic mechanism of BBE-like oxidases from Morus alba involved in the oxidative cyclization and dehydrogenation of moracin C. X-ray crystal structures of a functionally promiscuous flavin adenine dinucleotide (FAD)-bound oxidase, MaDS1, with and without ...
• Indigenous fire stewardship shaped North American Great Lakes forests AI翻译
  作者：Larson, Evan R.; Montano, Nisogaabokwe Melonee; Lockling, Emily; Ojibway, Ashla; Reynolds, Mocha B.; Zhaawendaagozikwe, Valerie Ross; Johnson, Lane B.; Kipfmueller, Kurt F.; Dockry, Michael J.; Northrup, Vern; Savage, Jeff; Kimmerer, Robin Wall
  作者单位：University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota System; University of Minnesota Twin Cities; State University of New York (SUNY) System; State University of New York (SUNY) College of Environmental Science & Forestry
  摘要：Interest in bringing Traditional Ecological Knowledge (TEK) and Western Science together to enhance climate and landscape resilience is growing rapidly, particularly for engagement with pyrogenic communities around the world. For these systems, Indigenous Knowledge offers unique insights that reflect millennia of intimate engagement with local landscapes, while Western Science can offer additional understanding of the emergence of climates and ecological conditions that are novel at evolutiona...
• FADDDED filaments coordinate complex IIa assembly during TNF-induced apoptosis AI翻译
  作者：Chen, Ying; Huynh, Vinh Thang; Lai, Lihua; Liu, Ping; Li, Tongyang; Tan, Yaw Bia; Chew, Che Shin; Velazquez, Amhed Missael Vargas; Samsudin, Firdaus; Marzinek, Jan K.; Bond, Peter J.; Wu, Bin; Luo, Dahai; Tergaonkar, Vinay
  作者单位：Agency for Science Technology & Research (A*STAR); A*STAR - Institute of Molecular & Cell Biology (IMCB); Nanyang Technological University; Nanyang Technological University; Agency for Science Technology & Research (A*STAR); A*STAR - Bioinformatics Institute (BII); National University of Singapore; Nanyang Technological University; National Centre for Infectious Diseases Singapore; National University of Singapore
  摘要：Extrinsic apoptosis is initiated by signaling from death receptors, leading to the assembly of RIPK1, FADD, and caspase-8 complex. Subsequently, caspase-8 forms a filamentous structure through the oligomerization of its tandem death effector domain (tDED), resulting in caspase activation and cell death. Although the DED of FADD (FADDDED) is homologous to the tDEDs of caspase-8 (casp8tDED) and both oligomerize to function, the functional form of FADDDED oligomer in extrinsic apoptosis remains u...
• Into the belly of the brainstem: The neurons of the extended enteric nervous system AI翻译
  作者：Moore, Jeffrey D.
  作者单位：University of Southern California
• Melanocyte- dependent macrophage redistribution enhances skin immunity upon acute stress AI翻译
  作者：Faught, Erin; Schaaf, Marcel J. M.
  作者单位：Leiden University - Excl LUMC; Leiden University; Radboud University Nijmegen
  摘要：It is well established that stress generally suppresses immunity. However, under certain conditions, acute stress has been shown to stimulate the immune system, particularly those at barrier surfaces like the skin. The cellular and molecular mechanisms underlying this effect remain poorly understood. In the present study, we have identified an immune-enhancing effect of stress using zebrafish larvae. The use of this animal model allowed us to visualize the redistribution of macrophages to the ...
• Warming climate and water withdrawals threaten river flow connectivity in China AI翻译
  作者：Gou, Jiaojiao; Miao, Chiyuan; Ni, Jinren; Sorooshian, Soroosh; Duan, Qingyun; Yan, Denghua; Slater, Louise; Xu, Zongxue; Borthwick, Alistair G. L.; Su, Lu; Zhang, Qi; Wada, Yoshihide
  作者单位：Beijing Normal University; Beijing Normal University; Peking University; University of California System; University of California Irvine; Hohai University; China Institute of Water Resources & Hydropower Research; University of Oxford; Beijing Normal University; University of Edinburgh; University of Plymouth; University of California System; University of California Los Angeles; King Abdullah University of Science & Technology
  摘要：River flow connectivity, the continuity of fluvial discharge in space and time, provides a crucial lifeline for most biotic communities on Earth. Yet there is still limited understanding of the impacts of climate change and human water withdrawal on river connectivity. Here, we assess the river flow connectivity of 217,001 river reaches in mainland China from 1961 to 2020 and the impact of different climate warming trends and water withdrawals for different sectors. We estimate that naturally ...
• Climate variability amplifies the need for vector-borne disease outbreak preparedness AI翻译
  作者：Hart, William S.; Hurrell, James W.; Kaye, Alexander R.; Chand, Meera; Keeling, Matt J.; Thompson, Robin N.
  作者单位：University of Oxford; Colorado State University System; Colorado State University Fort Collins; University of Warwick; University of Warwick; UK Health Security Agency (UKHSA)
  摘要：In locations that do not currently experience vector-borne disease (VBD) outbreaks but may be at risk under climate change, modeling future climate suitability for transmission is important for outbreak preparedness. Uncertainty in the future climate arises from three sources-differences in emissions scenarios, structural uncertainty across climate models, and internal climate variability (ICV)-but ICV is rarely considered in climate-VBD studies. Here, we demonstrate that ICV is a key source o...
• The Medicago truncatula lncRNA ENOD40 is a mediator of microRNA169- controlled NF-YA activity in nodule initiation AI翻译
  作者：Wijsman, Tristan; Mohd-Radzman, Nadia A.; Liu, Jieyu; Oldroyd, Giles E. D.; Kohlen, Wouter; Kulikova, Olga; Heidstra, Renze; Scheres, Ben; Franssen, Henk J.
  作者单位：Wageningen University & Research; University of Cambridge; University of Cambridge
  摘要：The hallmark of the legume lncRNA EARLY NODULIN40 (ENOD40), involved in rhizobium- induced nodulation, is the presence of a highly conserved stretch of 24 nucleotides, designated box2, preceded by a small open- reading- frame (sORF) coding for a peptide of 12 to 13 amino acids. Although there is a well- established link between ENOD40 and nodulation, it is not fully clear by which mechanism ENOD40 functions in this process. Here, we show that a region harboring box2 can complement nodule forma...