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作者：Andrianova, Ekaterina P.; Dobbins, Amanda L.; Erhardt, Marc; Hendrixson, David R.; Zhulin, Igor B.
作者单位：University System of Ohio; Ohio State University; University System of Ohio; Ohio State University; Humboldt University of Berlin
摘要：The bacterial flagellum is a complex nanomachine essential for motility, environmental sensing, and host colonization. While many of its core components have been well characterized, the relevance of proteins such as FliO, which are inconsistently annotated and poorly conserved at the sequence level, has remained ambiguous in their evolutionary and functional status. Here, we present a comprehensive phylogenomic and structural analysis of FliO across >30,000 representative genomes spanning >10...
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作者：Chen, Dawn S.; Marrero, Kianairy; Sanchez-Lopez, Javier Arturo; Belenky, Michael; Thomalla, Jonathon M.; Buehner, Norene A.; Apel, Ido; Levi, Yarin; Hafezi, Yassi; Wang, Shuran; Clark, Andrew G.; Heifetz, Yael; Siegal, Mark L.; Wolfner, Mariana F.
作者单位：Cornell University; New York University; Hebrew University of Jerusalem; University of Pennsylvania
摘要：Paired structures often have similar forms and functions, but the processes underlying their formation can differ. They may originate from a common source or from parallel sources, or arise from distinct precursors that follow separate developmental pathways, ultimately converging on comparable structures and roles. When asymmetries emerge and persist through development, members of the pair can specialize in ways that might increase fitness. Here, we report that the Drosophila melanogaster fe...
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作者：Farfan-Rios, William; Feeley, Kenneth J.; Myers, Jonathan A.; Tello, Sebastian; Sallo-Bravo, Jhonatan; Malhi, Yadvinder; Phillips, Oliver L.; Baker, Timothy R.; Nina-Quispe, Alex; Garcia-Cabrera, Karina; Saatchi, Sasan S.; Terborgh, John W.; Pitman, Nigel C. A.; Mendoza, Abel Lorenzo Monteagudo; Vasquez, Rodolfo; Salinas, Norma; Cayola, Leslie; Claros, Alfredo Fuentes; Loza, Maria I.; Vargas, Percy Nunez; Silman, Miles R.
作者单位：Wake Forest University; Wake Forest University; Washington University (WUSTL); University of Miami; Washington University (WUSTL); Missouri Botanical Gardens; Universidad Nacional de San Antonio Abad del Cusco; University of Oxford; University of Leeds; Pontificia Universidad Catolica del Peru; Pontificia Universidad Catolica del Peru; California Institute of Technology; National Aeronautics & Space Administration (NASA); NASA Jet Propulsion Laboratory (JPL); University of California System; University of California Los Angeles; State University System of Florida; University of Florida; James Cook University; Field Museum of Natural History (Chicago); Universidad Mayor de San Andres; University of Missouri System; University of Missouri Saint Louis
摘要：Climate change is shifting species distributions, leading to changes in community composition and novel species assemblages worldwide. However, the responses of tropical forests to climate change across large-scale environmental gradients remain largely unexplored. Using long-term data over 66,000 trees of more than 2,500 species occurring over 3,500 m elevation along the hyperdiverse Amazon-to-Andes elevational gradients in Peru and Bolivia, we assessed community-level shifts in species compo...
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作者：Schaefer, Martin; Malacrino, Antonino; Walcher, Christoph; Spaak, Piet; Sarazova, Marie Serwaty -; Kaeser, Silvana; Bulas, Thea; Dambone-Boesch, Christine; Dexter, Eric; Hottinger, Juergen; Boettner, Laura; Vorburger, Christoph; Ebert, Dieter; Xu, Shuqing
作者单位：Johannes Gutenberg University of Mainz; University of Munster; Clemson University; Universita Mediterranea di Reggio Calabria; Swiss Federal Institutes of Technology Domain; Swiss Federal Institute of Aquatic Science & Technology (EAWAG); University of Basel; Johannes Gutenberg University of Mainz
摘要：Indirect ecological effects occur when the impact of one species on another is mediated by a third species or the shared environment. Although indirect effects are ubiquitous in nature, we know remarkably little about how they may drive ecoevolutionary processes across community boundaries. Here, we show that insect (aphid) herbivory on macrophytes (duckweed) drove the adaptive evolution of a planktonic crustacean (Daphnia magna) in large outdoor aquatic mesocosms via indirect ecological effec...
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作者：Ucar, Mehmet Can; Alsberga, Zane; Alanko, Jonna; Sixt, Michael; Hannezo, Edouard
作者单位：Institute of Science & Technology - Austria; University of Sheffield; University of Turku; Abo Akademi University
摘要：Cell and tissue movement in development, cancer invasion, and immune response relies on chemical or mechanical guidance cues. In many systems, this behavior is locally directed by self-generated signaling gradients rather than long-range, prepatterned cues. However, how heterogeneous mixtures of cells interact nonreciprocally and navigate through self-generated gradients remains largely unexplored. Here, we introduce a theoretical framework for the self-organized chemotaxis of heterogeneous ce...
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作者：Yasui, Kotaro; Gupta, Astha; Fu, Qiyuan; Suzuki, Shura; Hainer, Jeffrey; Paez, Laura; Lutek, Keegan; Arreguit, Jonathan; Kano, Takeshi; Standen, Emily M.; Ijspeert, Auke J.; Ishiguro, Akio
作者单位：Tohoku University; Tohoku University; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; University of Ottawa; Villanova University; Future University Hakodate
摘要：Vertebrate locomotion is due to the interplay of neural oscillators and sensory feedback loops in the spinal cord that interact with the body and the environment. Here, we study these circuits with a focus on undulatory locomotion as produced by elongated fish such as eels and lampreys. We address three questions: i) How do proprioception (stretch feedback) and exteroception (pressure on skin) interact with local oscillators to generate stable swimming patterns? ii) Can these feedback loops al...
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作者：Faught, Erin; Schaaf, Marcel J. M.
作者单位：Leiden University - Excl LUMC; Leiden University; Radboud University Nijmegen
摘要：It is well established that stress generally suppresses immunity. However, under certain conditions, acute stress has been shown to stimulate the immune system, particularly those at barrier surfaces like the skin. The cellular and molecular mechanisms underlying this effect remain poorly understood. In the present study, we have identified an immune-enhancing effect of stress using zebrafish larvae. The use of this animal model allowed us to visualize the redistribution of macrophages to the ...
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作者：Gou, Jiaojiao; Miao, Chiyuan; Ni, Jinren; Sorooshian, Soroosh; Duan, Qingyun; Yan, Denghua; Slater, Louise; Xu, Zongxue; Borthwick, Alistair G. L.; Su, Lu; Zhang, Qi; Wada, Yoshihide
作者单位：Beijing Normal University; Beijing Normal University; Peking University; University of California System; University of California Irvine; Hohai University; China Institute of Water Resources & Hydropower Research; University of Oxford; Beijing Normal University; University of Edinburgh; University of Plymouth; University of California System; University of California Los Angeles; King Abdullah University of Science & Technology
摘要：River flow connectivity, the continuity of fluvial discharge in space and time, provides a crucial lifeline for most biotic communities on Earth. Yet there is still limited understanding of the impacts of climate change and human water withdrawal on river connectivity. Here, we assess the river flow connectivity of 217,001 river reaches in mainland China from 1961 to 2020 and the impact of different climate warming trends and water withdrawals for different sectors. We estimate that naturally ...
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作者：Hart, William S.; Hurrell, James W.; Kaye, Alexander R.; Chand, Meera; Keeling, Matt J.; Thompson, Robin N.
作者单位：University of Oxford; Colorado State University System; Colorado State University Fort Collins; University of Warwick; University of Warwick; UK Health Security Agency (UKHSA)
摘要：In locations that do not currently experience vector-borne disease (VBD) outbreaks but may be at risk under climate change, modeling future climate suitability for transmission is important for outbreak preparedness. Uncertainty in the future climate arises from three sources-differences in emissions scenarios, structural uncertainty across climate models, and internal climate variability (ICV)-but ICV is rarely considered in climate-VBD studies. Here, we demonstrate that ICV is a key source o...
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作者：Wijsman, Tristan; Mohd-Radzman, Nadia A.; Liu, Jieyu; Oldroyd, Giles E. D.; Kohlen, Wouter; Kulikova, Olga; Heidstra, Renze; Scheres, Ben; Franssen, Henk J.
作者单位：Wageningen University & Research; University of Cambridge; University of Cambridge
摘要：The hallmark of the legume lncRNA EARLY NODULIN40 (ENOD40), involved in rhizobium- induced nodulation, is the presence of a highly conserved stretch of 24 nucleotides, designated box2, preceded by a small open- reading- frame (sORF) coding for a peptide of 12 to 13 amino acids. Although there is a well- established link between ENOD40 and nodulation, it is not fully clear by which mechanism ENOD40 functions in this process. Here, we show that a region harboring box2 can complement nodule forma...
