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作者：Yin, Shenglai; Zhang, Chenchen; Teitelbaum, Claire S.; Si, Yali; Zhang, Geli; Wang, Xinxin; Mao, Dehua; Huang, Zheng Y. X.; de Boer, Willem Frederik; Takekawa, John; Prosser, Diann J.; Xiao, Xiangming
作者单位：University of Oklahoma System; University of Oklahoma - Norman; United States Department of the Interior; United States Geological Survey; University System of Georgia; University of Georgia; United States Department of the Interior; United States Geological Survey; Leiden University - Excl LUMC; Leiden University; China Agricultural University; Fudan University; Chinese Academy of Sciences; Northeast Institute of Geography & Agroecology, CAS; Nanjing Forestry University; Wageningen University & Research
摘要：Highly pathogenic avian influenza viruses (HPAIV) persistently threaten wild waterfowl, domestic poultry, and public health. The East Asian-Australasian Flyway plays a crucial role in HPAIV dynamics due to its large populations of migratory waterfowl and poultry. Over recent decades, this flyway has undergone substantial landscape changes, including both losses and gains of waterfowl habitats. These changes can affect waterfowl distributions, increase contact with poultry, and consequently alt...
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作者：Ji, Yang; Parashar, Shubham; Miyamoto, Yukiko; Srivastava, Saurabh; Lewis, Amanda L.; Varki, Nissi; Varki, Ajit; Eckmann, Lars
作者单位：University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego; Southern University of Science & Technology
摘要：Sialic acids (Sias) are a diverse family of nine-carbon backbone monosaccharides occupying terminal positions on cell surface and secreted glycans and are abundant at mucosal surfaces. Sias can be modified with O-acetyl esters on the side chain (C7 to C9) hydroxyls. Structural analysis and functional studies of these modifications are challenging due to chemical lability and variable resistance to sialidases. For in-depth analysis of the expression and functions of O-acetyl Sia modifications, ...
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作者：Schuler, Thomas Vikhamar; Benestad, Rasmus Emil; Isaksen, Ketil; Kierulf, Halfdan Pascal; Kohler, Jack; Moholdt, Geir; Schmidt, Louise Steffensen
作者单位：University of Oslo; Norwegian Meteorological Institute; Norwegian Polar Institute
摘要：A record-breaking melt season affected the Arctic glaciers of Svalbard in summer 2024 by a substantial margin. Across the entire archipelago, glacier melting corresponded to an anomaly of up to four SD and exceeded any previous observation. The pan-Svalbard mass loss in summer 2024 amounts to similar to 61.7 +/- 11.1 Gt and corresponds to 1% of the total ice volume on Svalbard and is comparable to that of the Greenland ice sheet (55 +/- 35 Gt), which occupies an area about 50 times larger. Alt...
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作者：Curtis, Samuel D.; Panda, Sambit; Li, Adam; Xu, Haoyin; Bai, Yuxin; Ogihara, Itsuki; O'Reilly, Eliza; Wang, Yuxuan; Dobbyn, Lisa; Popoli, Maria; Ptak, Janine; Nehme, Nadine; Silliman, Natalie; Tie, Jeanne; Gibbs, Peter; -Pham, Lan T. Ho; Tran, Bich N. H.; Tran, Thach S.; Nguyen, Tuan V.; Irajizad, Ehsan; Goggins, Michael; Wolfgang, Christopher L.; Wang, Tian-Li; Shih, Ie-Ming; Fader, Amanda; Lennon, Anne Marie; Hruban, Ralph H.; Bettegowda, Chetan; Gilbert, Lucy; Kinzler, Kenneth W.; Papadopoulos, Nickolas; Vogelstein, Bert; Vogelstein, Joshua T.; Douville, Christopher
作者单位：Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins University; Columbia University; Johns Hopkins University; Johns Hopkins University; Howard Hughes Medical Institute; Walter & Eliza Hall Institute; University of Melbourne; Peter Maccallum Cancer Center; University of Melbourne; Western Health; University of Technology Sydney; University of Technology Sydney; University of New South Wales Sydney; Johns Hopkins University; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins Medicine; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Johns Hopkins University; McGill University; Johns Hopkins University
摘要：AI is now a cornerstone of modern dataset analysis. In many real world applications, practitioners are concerned with controlling specific kinds of errors, rather than minimizing the overall number of errors. For example, biomedical screening assays may primarily be concerned with mitigating the number of false positives rather than false negatives. Quantifying uncertainty in AI-based predictions, and in particular those controlling specific kinds of errors, remains theoretically and practical...
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作者：Dang, Pengfei; Ciais, Philippe; Gao, Jiaxin; Zhu, Yunxiao; Xue, Jiquan; Qin, Xiaoliang; Ros, Gerard H.
作者单位：Northwest A&F University - China; Universite Paris Saclay; Wageningen University & Research
摘要：Carbon sequestration through plant biomass responses to global warming plays a vital role in mitigating climate change, but recent evidence suggests that this effect diminishes in the long term. To investigate the effect of warming duration on plant biomass responses, we analyzed a global dataset of 2,291 paired observations, revealing that warming increased overall aboveground plant biomass by 9.4% and belowground biomass by 2.6%. However, as the warming duration increased, the positive plant...
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作者：Kuroda, Junya; Puthalakath, Hamsa; Cragg, Mark S.; Kelly, Priscilla N.; Bouillet, Philippe; Huang, David C. S.; Kimura, Shinya; Ottmann, Oliver G.; Druker, Brian J.; Villunger, Andreas; Roberts, Andrew W.; Strasser, Andreas
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作者：Pyne, Stephen
作者单位：Arizona State University; Arizona State University-Tempe
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作者：Forey, Romain; Raclot, Charlene; Pulver, Cyril; Rosspopoff, Olga; Offner, Sandra; Duc, Julien; Planet, Evarist; Martins, Filipe; Turelli, Priscilla; Trono, Didier
作者单位：Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Swiss School of Public Health (SSPH+)
摘要：ZNF93 is a primate-restricted Kr & uuml;ppel-associated box zinc finger protein responsible for repressing 20-to 12-My-old L1 transposable elements. Here, we reveal that ZNF93 also regulates the key cancer driver APOBEC3B-a mutagenic enzyme linked to tumorigenesis and cancer progression. ZNF93 depletion impairs DNA synthesis, activates replication and DNA damage checkpoints, and triggers proinflammatory phenotypes. Conversely, its overexpression enhances resistance to exogenous genotoxic stres...
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作者：Qiu, Yu; Cen, Renyue
作者单位：Zhejiang University; Zhejiang University
摘要：Suppression effects of giant radio lobes from supermassive black holes on gas accretion onto galaxies in the surrounding regions are quantified using cosmological magneto-hydrodynamic simulations. With an appropriate amount of radio jet energy injected into the intergalactic medium following the formation peak of supermassive black holes at redshift two, we find that galaxies in the greater neighborhood of the jet-launching massive galaxies subsequently experience a significant reduction in th...
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作者：Zhou, Junxiang; Feng, Chihin; Sun, Yue; Noma, Kentaro; Jin, Yishi
作者单位：University of California System; University of California San Diego; Nagoya University
摘要：The microtubule (MT) cytoskeleton is essential for neuronal morphology, neurite growth, synapse formation and maintenance, as well as regulation of signal transduction. Most cells express multiple isotypes of alpha- and beta-tubulin that can coassemble into MTs. While a variety of signaling pathways regulate MT integrity and homeostasis, little is known about how tubulin isotypes interact in vivo. Here, we report a mechanism in conserved kinase DLK-1 and its downstream signal transduction, whi...
