34期

最新文章

• Identifying fish populations prone to abrupt shifts via dynamical footprint analysis AI翻译
  作者：Radhakrishnan, Adityanarayanan; Jain, Yajit; Uhler, Caroline; Lander, Eric S.
  作者单位：Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Harvard University; Harvard Medical School
  摘要：Fish population biomass fluctuates through time in ways that may be either gradual or abrupt. While abrupt shifts in fish population productivity have been shown to be common, they are rarely integrated into stock assessment or fishery management, in part because of the difficulty of predicting when abrupt shifts may occur and which stocks are prone to such shifts. In this study, we address the latter challenge by designing a mechanism-agnostic context-specific approach that is based on exploi...
• Replay in the human visual cortex during brief task pauses is linked to implicit learning of successor representations AI翻译
  作者：Wittkuhn, Lennart; Krippner, Lena M.; Koch, Christoph; Schuck, Nicolas W.
  作者单位：University of Hamburg; Max Planck Society; University of Potsdam
  摘要：Humans can implicitly learn about multistep sequential relationships between events in the environment from their statistical co-occurrence. Theoretical work has suggested that neural replay is a candidate mechanism that aids such learning. Here, we used functional MRI (fMRI) to test whether replay is related to implicit learning of higher-order sequential relationships. Human participants viewed sequences of images that followed probabilistic transitions determined by ring-like graph structur...
• Soil eDNA reflects regionally dominant species rather than local composition of tropical tree communities AI翻译
  作者：Sayas, Francesc Borras; Iacovino, Ottavia; Uriarte, Maria; Zimmerman, Jess K.; Nytch, Christopher J.; Dunshea, Glenn; Muscarella, Robert
  作者单位：Uppsala University; Norwegian University of Science & Technology (NTNU); Columbia University
  摘要：Environmental DNA (eDNA) is increasingly used for biodiversity monitoring, but validation of the spatial scale(s) at which eDNA reflects extant communities is scarce, particularly in tropical forests: the terrestrial biome with the most concentrated diversity on earth. We leveraged spatially explicit tree inventory data from the 16-ha Luquillo Forest Dynamics Plot (LFDP) in Puerto Rico to validate soil eDNA as a spatially explicit indicator of tree diversity/composition. Using a comprehensive ...
• Synergistic action of specialized metabolites from divergent biosynthesis in the human oral microbiome AI翻译
  作者：Yao, McKenna Loop; Zill, Nicholas A.; Barber, Colin Charles; Du, Yongle; Lin, Peijun; Zhai, Rui; Yoon, Eunice; Al Marzooqi, Dunya; Zhang, Wenjun
  作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley
  摘要：Despite extensive efforts, our understanding of the virulence factors contributing to oral biofilm formation-a hallmark of dental caries-remains incomplete. We present evidence that the specialized metabolism of the oral microbiome is a critical yet under-explored factor in oral biofilm formation. Through microbiome analysis, we identified a hybrid nonribosomal peptide synthetase (NRPS) and polyketide synthase (PKS) encoding biosynthetic gene cluster that correlates with dental caries and is w...
• Systemic Kras ablation disrupts myeloid cell homeostasis in adult mice AI翻译
  作者：Zamorano-Dominguez, Elena; Morales-Cacho, Lucia; Barrero, Rebeca; Parrado, Silvia Jimenez-; Dhawahir, Alma; Hernandez-Porras, Isabel; Simon-Carrasco, Lucia; Barrambana, Sara; Sun, Pian; Galvan-del-Rey, Ana; Rosas-Perez, Blanca; Liaki, Vasiliki; Drosten, Matthias; Musteanu, Monica; Virga, Federico; Santos, Eugenio; Mulero, Francisca; Caleiras, Eduardo; Guerra, Carmen; Barbacid, Mariano
  作者单位：CIBER - Centro de Investigacion Biomedica en Red; CIBERONC; Instituto de Salud Carlos III; Consejo Superior de Investigaciones Cientificas (CSIC); Universidad Pablo de Olavide; University of Sevilla; CSIC - Centro Andaluz de Biologia Molecular y Medicina Regenerativa (CABIMER); University of Salamanca; Consejo Superior de Investigaciones Cientificas (CSIC); Complutense University of Madrid; Hospital Clinico San Carlos; Centro Nacional de Investigaciones Cardiovasculares (CNIC)
  摘要：The KRAS oncogene has been associated with many types of cancer, including pancreatic, lung, and colorectal. For decades, its gene products were thought to be undruggable. However, during the last decade, a large battery of KRAS inhibitors selective against specific mutations (KRASG12C and KRASG12D), panKRAS inhibitors active against all KRAS isoforms, or even panRAS inhibitors, capable of inhibiting the three members of the RAS family, have been developed. In mice, the Kras locus is essential...
• Danicamtiv reduces myosin's working stroke but activates the thin filament by accelerating actomyosin attachment AI翻译
  作者：Scott, Brent; Greenberg, Lina; Squarci, Caterina; Campbell, Kenneth S.; Greenberg, Michael J.
  作者单位：Washington University (WUSTL); University of Kentucky
  摘要：Heart failure is a leading cause of death worldwide, and even with current treatments, the 5-y transplant-free survival rate is only similar to 50 to 70%. As such, there is a need to develop new treatments for patients that improve survival and quality of life. Recently, there have been efforts to develop small molecules for heart failure that directly target components of the sarcomere, including cardiac myosin. Danicamtiv is one of these molecules; however, its direct effects on myosin's sin...
• Pervasive and recurrent hybridization prevents inbreeding in Europe's most threatened seabird AI翻译
  作者：Izquierdo-Aranega, Guillem; Cuevas-Caballe, Cristian; Giannelli, Francesco; Paris, Josephine R.; Bourgeois, Karen; Trucchi, Emiliano; Gonzalez-Solis, Jacob; Riutort, Marta; Obiol, Joan Ferrer; Rozas, Julio
  作者单位：University of Barcelona; University of Barcelona; University of Barcelona; Marche Polytechnic University; Centre National de la Recherche Scientifique (CNRS); Aix-Marseille Universite; Avignon Universite; Institut de Recherche pour le Developpement (IRD); University of Milan; Colorado State University System; Colorado State University Fort Collins
  摘要：Hybridization is a double- edged sword: While it can erode distinct evolutionary lineages, it can also introduce genetic diversity and adaptive potential into dwindling populations. In the Critically Endangered Balearic shearwater (Puffinus mauretanicus), this dilemma is exacerbated by a limited understanding of the extent and consequences of hybridization with the Yelkouan shearwater (Puffinus yelkouan). This knowledge gap has limited the scope of science- based conservation strategies to avo...
• Macrophage TBK1 signaling drives the development and outgrowth of breast cancer brain metastasis AI翻译
  作者：Khan, Fatima; Liu, Yang; Whitfield, Donovan; Pang, Lizhi; Ali, Heba; Huang, Yuyun; Zhou, Fei; Hagan, Robert S.; Frenis, Katie; Rowe, R. Grant; Chen, Peiwen
  作者单位：Cleveland Clinic Foundation; Northwestern University; Feinberg School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; University System of Ohio; Case Western Reserve University
  摘要：Tumor-associated macrophages (TAMs) are the predominant immune cells in the tumor microenvironment that promote breast cancer brain metastasis (BCBM). Here, we identify TANK-binding kinase (TBK1) as a critical signaling molecule enriched and activated in TAMs of BCBM tumors, playing an indispensable role in BCBM development and metastatic outgrowth in the brain. Mechanistically, BCBM cell-secreted matrix metalloproteinase 1 binds to protease-activated receptor 1 and integrin alpha V beta 5 on ...
• The nature of ant caste allometry AI翻译
  作者：Linksvayer, Timothy A.
  作者单位：Arizona State University; Arizona State University-Tempe
• Definition of the components required for selective packaging of coronavirus genomic RNA AI翻译
  作者：Pata, Janice D.; Stevens, Taina K.; Kuo, Lili; Masters, Paul S.
  作者单位：State University of New York (SUNY) System; Wadsworth Center; State University of New York (SUNY) System; University at Albany, SUNY; State University of New York (SUNY) System; University at Albany, SUNY; Wadsworth Center
  摘要：Most cytoplasmic RNA viruses have evolved mechanisms to identify their genomic RNA (gRNA) as the sole RNA species to be packaged into assembled virions. Coronaviruses exhibit highly selective packaging of their gRNA, in spite of the presence of a large excess of subgenomic viral and host RNA in infected cells. Failure to accomplish this selectivity does not impair virion assembly but renders the virus vulnerable to host innate immunity. In the prototype coronavirus mouse hepatitis virus (MHV) ...