34期

最新文章

• Indigenous fire stewardship shaped North American Great Lakes forests AI翻译
  作者：Larson, Evan R.; Montano, Nisogaabokwe Melonee; Lockling, Emily; Ojibway, Ashla; Reynolds, Mocha B.; Zhaawendaagozikwe, Valerie Ross; Johnson, Lane B.; Kipfmueller, Kurt F.; Dockry, Michael J.; Northrup, Vern; Savage, Jeff; Kimmerer, Robin Wall
  作者单位：University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota System; University of Minnesota Twin Cities; State University of New York (SUNY) System; State University of New York (SUNY) College of Environmental Science & Forestry
  摘要：Interest in bringing Traditional Ecological Knowledge (TEK) and Western Science together to enhance climate and landscape resilience is growing rapidly, particularly for engagement with pyrogenic communities around the world. For these systems, Indigenous Knowledge offers unique insights that reflect millennia of intimate engagement with local landscapes, while Western Science can offer additional understanding of the emergence of climates and ecological conditions that are novel at evolutiona...
• Protein functional site annotation using local structure embeddings AI翻译
  作者：Derry, Alexander; Tartici, Alp; Altman, Russ B.
  作者单位：Stanford University; Stanford University; Stanford University
  摘要：The rapid expansion of protein sequence and structure databases has resulted in a significant number of proteins with ambiguous or unknown function. While advances in machine learning techniques hold great potential to fill this annotation gap, current methods for function prediction are unable to associate global function reliably to the specific residues responsible for that function. We address this issue by introducing PARSE (Protein Annotation by Residue-Specific Enrichment), a knowledge-...
• Evolution of developmental bias explains divergent patterns of phenotypic evolution in two nematode clades AI翻译
  作者：Picao-Osorio, Joao; Bouleau, Charlotte; de la Rosa, Pablo M. Gonzalez; Stevens, Lewis; Fekonja, Nina; Blaxter, Mark; Braendle, Christian; Felix, Marie-Anne
  作者单位：Institut National de la Sante et de la Recherche Medicale (Inserm); Universite PSL; Ecole Normale Superieure (ENS); Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Universite Cote d'Azur; Wellcome Trust Sanger Institute; Universidade de Lisboa
  摘要：Rates of phenotypic evolution vary across traits, and these evolutionary patterns themselves evolve. Understanding how development contributes to such patterns remains a challenge because it requires large-scale measurement of phenotypic variation resulting from random mutations across multiple species. Using the experimentally tractable system of nematode vulval development, we quantified the evolution and mutational sensitivity of six cell fates across two clades. First, we find that the cel...
• Negative interplay between HIV-1 Gag and amyloid precursor protein centers around competition for VPS4A and TSG101 AI翻译
  作者：Gu, Feng; Naghavi, Mojgan H.
  作者单位：Northwestern University; Feinberg School of Medicine
  摘要：Intracellular multivesicular bodies (MVBs) act as sites of assembly and release of HIV type 1 (HIV-1) in macrophages and microglia. Recent work has shown that processing of amyloid precursor protein (APP) into a C-terminal fragment (CTF), termed C99, inhibits HIV-1 access to CD63+ MVBs and to counteract this, HIV-1 Group-specific antigen (Gag) increases C99 processing into toxic amyloids. However, the underlying reasons for this negative interplay between Gag and C99 remain unclear. Here, we s...
• Nitric oxide promotes cysteine N-degron proteolysis through control of oxygen availability AI翻译
  作者：Kim, Haeun; Tian, Ya-Min; Ratcliffe, Peter J.; Keeley, Thomas P.
  作者单位：University of Oxford; University of Oxford; Ludwig Institute for Cancer Research; Francis Crick Institute; University of Oxford
  摘要：Selected proteins containing an N-terminal cysteine (Nt-Cys) are subjected to rapid, O2-dependent proteolysis via the Cys/Arg-branch of the N-degron pathway. Cysteine dioxygenation is catalyzed in mammalian cells by 2-aminoethanethiol dioxygenase (ADO), an enzyme that manifests extreme O2 sensitivity.The canonical substrates of this pathway in mammalia are the regulators of G-protein signaling 4, 5, and 16, as well as interleukin-32. In addition to operating as an O2-sensing mechanism, this pa...
• CO2 upgrading into bioproducts using a two-step abiotic-biotic system AI翻译
  作者：Lee, Geonhui; Jo, Hye -Jin; Choi, Jihoon; Guzman, Maria Fonseca; Shan, Yu; Le, Han K. D.; Feijoo, Julian; Soland, Nathan; Clark, Douglas S.; Yang, Peidong
  作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory
  摘要：The valorization of CO2 to chemicals beyond C1-2 products is receiving significant interest; however, the direct electrosynthesis of C-n molecules (n > 4) remains a challenge. Here, we present a two-step abiotic-biotic system for upgrading CO2 into the biopolymer, poly(3-hydroxybutyrate). In the electrolysis system, CO2 is converted into C-2 oxygenates using a Cu-Ag tandem electrocatalyst. The electrolysis process generates a liquid stream containing similar to 200 mM acetate in a bio-compatib...
• Opposing action of photosystem II assembly factors RBD1 and HCF136 underlies light- regulated psbA translation in plant chloroplasts AI翻译
  作者：Rojas, Margarita; Carrier, Rosalind Williams -; Chotewutmontri, Prakitchai; Belcher, Susan; Boyce, Emily; Barkan, Alice
  作者单位：University of Illinois System; University of Illinois Urbana-Champaign; United States Department of Agriculture (USDA)
  摘要：The D1 subunit of photosystem II (PSII) is subject to light- induced damage. In plants, D1 photodamage activates translation of chloroplast psbA mRNA encoding D1, providing D1 for PSII repair. Three D1 assembly factors have been implicated in the regulatory mechanism: HCF244 and RBD1 activate psbA translation, whereas HCF136 represses psbA translation in the dark. To clarify the regulatory circuit, we analyzed psbA ribosome occupancy in dark- adapted and illuminated rbd1 and rbd1;hcf136 double...
• Liquid water might not be the only answer: Evaluating pore-filling materials in the Martian crust AI翻译
  作者：Xiao, Wanbo; Pan, Lu; Wang, Yanbin; Li, Jiaqi
  作者单位：Peking University; Chinese Academy of Sciences; University of Science & Technology of China, CAS
• Programmable immunoprobiotics orchestrate antitumor immune response with Pin1 inhibition for pancreatic cancer treatment AI翻译
  作者：Yuan, Sichen; Yang, Xicheng; Bremmer, Alexa M.; Wang, Yixin; Li, Sherry; Chen, Yu; You, Yawen; Hu, Quanyin
  作者单位：University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison
  摘要：Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with limited treatment options due to its desmoplastic and immunosuppressive tumor microenvironpoint blockade (ICB) has shown poor efficacy in PDAC, partly due to the desmoplastic stroma and low immunogenicity. Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 (Pin1) promotes both fibrosis and immune evasion, making it a compelling target PD-L1 blockade to enhance immunotherapy. This system uses Escherichia coli Nissle ...