34期

最新文章

• The rise of diversity terminology in biomedical research AI翻译
  作者：Kramer, Brandon L.; Lee, Catherine
  作者单位：Rutgers University System; Rutgers University New Brunswick
  摘要：Recent scholarship has highlighted the rise of diversity projects across various educational and business contexts, but few studies have explored the meaning of diversity in biomedical research. In this paper, we employ a computationally driven matching technique to examine quantitative trends in the use of various forms of diversity and population terminology in a sample of nearly two million biomedical abstracts spanning a 30-y period. The curated dictionaries we leverage to detect these tre...
• Life's homochirality: Across a prebiotic network AI翻译
  作者：Ozturk, S. Furkan; Sasselov, Dimitar D.
  作者单位：Smithsonian Astrophysical Observatory; Smithsonian Institution; Harvard University; University of Cambridge
  摘要：For centuries, scientists have been puzzled by the mystery of life's biomolecular homochirality-the singlehandedness of biological compounds. Sugars and nucleic acids are right-handed, while amino acids are left-handed in biological systems. Likewise, certain metabolites are homochiral, though their handedness varies. However, efforts to address the homochirality problem have often focused on a single compound, a single molecular class, or invoke an extraterrestrial origin. Here, we emphasize ...
• Reply to Xiao et al.: A wet or dry Martian mid-crust, that is only part of the question AI翻译
  作者：Wright, Vashan; Morzfeld, Matthias; Manga, Michael
  作者单位：University of California System; University of California San Diego; Scripps Institution of Oceanography; University of California System; University of California Berkeley
• Monoamine-induced diacylglycerol signaling rapidly accumulates Unc13 in nanoclusters for fast presynaptic potentiation AI翻译
  作者：Blaum, Natalie; Ghelani, Tina; Gotz, Torsten W. B.; Chronister, Keagan S.; Bengochea, Mercedes; Ceresnova, Livia; Christensen, Christian F.; Moulin, Thiago C.; Kern, Hanna; Thomas, Ulrich; Heine, Martin; Sigrist, Stephan J.; Walter, Alexander M.
  作者单位：University of Copenhagen; Free University of Berlin; Johannes Gutenberg University of Mainz; Leibniz Association; Leibniz Institut fur Neurobiologie (LIN)
  摘要：Neuromodulators control mood, arousal, and behavior by inducing synaptic plasticity via G-protein-coupled receptors. While long-term presynaptic potentiation requires structural changes, mechanisms enabling potentiation within minutes remain unclear. Using the Drosophila neuromuscular junction, we show that octopamine, the invertebrate analog of norepinephrine, potentiates evoked neurotransmitter release on the timescale of one minute via a G-protein-coupled pathway involving presynaptic OAMB ...
• Cognitive bridge between geometric and numerical learning in monkeys AI翻译
  作者：Cantlon, Jessica F.; Brownell, Logan R.; Li, Jialin; DeLong, Caroline M.
  作者单位：Carnegie Mellon University; Rochester Institute of Technology
  摘要：Educational research highlights strong developmental links between numerical and spatial cognition in humans, often shaped by cultural tools like the number line. However, emerging evidence suggests that these number-space connections may reflect our evolutionary history and emerge even in the absence of cultural tools. We examined how task-na & iuml;ve monkeys learn spatial and numerical concepts over time. Monkeys' learning trajectories revealed successful learning of both numerical and geom...
• Reply to Michał Bogdziewicz et al.: Research on the summer solstice needs falsifiable predictions AI翻译
  作者：van der Meersch, Victor; Wolkovich, E. M.
  作者单位：University of British Columbia
• β- Catenin regulates myogenesis by relieving I-mfa-mediated suppression of myogenic regulatory factors in P19 cells (vol 102, pg 17378, 2005) AI翻译
  作者：Pan, Weijun; Jia, Yingying; Wang, Jiyong; Tao, Donglei; Gan, Xiaoqing; Tsiokas, Leonidas; Jing, Naihe; Wu, Dianqing; Li, Lin
• Altricial brains and the evolution of infant vocal learning AI翻译
  作者：Biazzi, Renata B.; Takahashi, Daniel Y.; Ghazanfar, Asif A.
  作者单位：Princeton University; Princeton University
  摘要：Vocal development in human infants is strongly influenced by interactions with caregivers who reinforce more speech-like sounds. This trajectory of vocal development in humans is radically different from those of our close phylogenetic relatives, cercopithecoid monkeys and apes. In these primates, social feedback seems to play no significant role in their vocal development. Oddly,marmoset monkeys, a more distantly related primate species, do exhibit socially guided vocal learning. How can this...
• CO2 hydration at the air-water interface: A surface-mediated in-and-out mechanism AI翻译
  作者：Brookes, Samuel G. H.; Kapil, Venkat; Michaelides, Angelos; Schran, Christoph
  作者单位：University of Cambridge; University of Cambridge; University of Cambridge; University of London; University College London; University of London; University College London
  摘要：An understanding of the CO2 + H2O hydration reaction is crucial for modeling the effects of ocean acidification, for enabling novel carbon storage solutions, and as a model process in the geosciences. While the mechanism of this reaction has been investigated extensively in the condensed phase, its mechanism at the air-water interface remains elusive, leaving uncertain the contribution that surface-adsorbed CO2 makes to the overall acidification reaction. In this study, we employ machine-learn...
• A universal of speech timing: Intonation units form low-frequency rhythms AI翻译
  作者：Inbar, Maya; Grossman, Eitan; Landau, Ayelet N.
  作者单位：Hebrew University of Jerusalem; Hebrew University of Jerusalem; Hebrew University of Jerusalem; University of London; University College London
  摘要：Intonation units (IUs) are a hypothesized universal building block of human speech [W. Chafe, Discourse, Consciousness and Time: The Flow and Displacement of Conscious Experience in Speaking and Writing (1994); N. P. Himmelmann et al., Phonology 35, 207-245 (2018)). Linguistic research suggests they are found across languages and that they fulfill important communicative functions such as the pacing of ideas in discourse and swift turn-taking. We study the rate of IUs in 48 languages from ever...