34期

最新文章

• Reply to Michał Bogdziewicz et al.: Research on the summer solstice needs falsifiable predictions AI翻译
  作者：van der Meersch, Victor; Wolkovich, E. M.
  作者单位：University of British Columbia
• β- Catenin regulates myogenesis by relieving I-mfa-mediated suppression of myogenic regulatory factors in P19 cells (vol 102, pg 17378, 2005) AI翻译
  作者：Pan, Weijun; Jia, Yingying; Wang, Jiyong; Tao, Donglei; Gan, Xiaoqing; Tsiokas, Leonidas; Jing, Naihe; Wu, Dianqing; Li, Lin
• Scaling and mechanical optimality of bristled wings in microinsects AI翻译
  作者：Kolomenskiy, Dmitry; Farisenkov, Sergey E.; Petrov, Pyotr N.; Polilov, Alexey A.
  作者单位：Skolkovo Institute of Science & Technology; Lomonosov Moscow State University
  摘要：It is crucial for both animal evolution and engineering to optimize the relative size of structures. Animal wings are no exception, every structural design having its limits in terms of achievable size and performance. For instance, many microinsects have bristled wings, which are more efficient at small scales than the membranous wings common in larger insects. However, the limitations and the optimal characteristics of bristled wings remain largely underinvestigated. We collected morphologic...
• A FRET assay to monitor different structural states of human β- cardiac myosin including the interacting-heads motif AI翻译
  作者：Goluguri, Rama Reddy; Guhathakurta, Piyali; Nandwani, Neha; Dawood, Aminah; Yokota, Seiji; Roopnarine, Osha; Thomas, David D.; Ruppel, Kathleen M.; Spudich, James A.
  作者单位：Stanford University; Stanford Medicine; University of Minnesota System; University of Minnesota Twin Cities; Stanford University; Stanford Medicine
  摘要：In cardiac muscle, myosin molecules exist in multiple structural states as they transit through their ATPase cycle, including an off-cycle resting or OFF-state with their catalytic heads in a folded structure known as the interacting-heads motif (IHM). The blocked head configuration (BHC) of the IHM is unusual because its light chain binding region is held in an exaggerated prestroke angle stabilized by interactions with its own S2 tail. An additional partial OFF-state, where the second head o...
• The rise of diversity terminology in biomedical research AI翻译
  作者：Kramer, Brandon L.; Lee, Catherine
  作者单位：Rutgers University System; Rutgers University New Brunswick
  摘要：Recent scholarship has highlighted the rise of diversity projects across various educational and business contexts, but few studies have explored the meaning of diversity in biomedical research. In this paper, we employ a computationally driven matching technique to examine quantitative trends in the use of various forms of diversity and population terminology in a sample of nearly two million biomedical abstracts spanning a 30-y period. The curated dictionaries we leverage to detect these tre...
• Life's homochirality: Across a prebiotic network AI翻译
  作者：Ozturk, S. Furkan; Sasselov, Dimitar D.
  作者单位：Smithsonian Institution; Smithsonian Astrophysical Observatory; Harvard University; University of Cambridge
  摘要：For centuries, scientists have been puzzled by the mystery of life's biomolecular homochirality-the singlehandedness of biological compounds. Sugars and nucleic acids are right-handed, while amino acids are left-handed in biological systems. Likewise, certain metabolites are homochiral, though their handedness varies. However, efforts to address the homochirality problem have often focused on a single compound, a single molecular class, or invoke an extraterrestrial origin. Here, we emphasize ...
• Reply to Xiao et al.: A wet or dry Martian mid-crust, that is only part of the question AI翻译
  作者：Wright, Vashan; Morzfeld, Matthias; Manga, Michael
  作者单位：University of California System; University of California San Diego; Scripps Institution of Oceanography; University of California System; University of California Berkeley
• Minimizing and quantifying uncertainty in AI-informed decisions: Applications in medicine AI翻译
  作者：Curtis, Samuel D.; Panda, Sambit; Li, Adam; Xu, Haoyin; Bai, Yuxin; Ogihara, Itsuki; O'Reilly, Eliza; Wang, Yuxuan; Dobbyn, Lisa; Popoli, Maria; Ptak, Janine; Nehme, Nadine; Silliman, Natalie; Tie, Jeanne; Gibbs, Peter; -Pham, Lan T. Ho; Tran, Bich N. H.; Tran, Thach S.; Nguyen, Tuan V.; Irajizad, Ehsan; Goggins, Michael; Wolfgang, Christopher L.; Wang, Tian-Li; Shih, Ie-Ming; Fader, Amanda; Lennon, Anne Marie; Hruban, Ralph H.; Bettegowda, Chetan; Gilbert, Lucy; Kinzler, Kenneth W.; Papadopoulos, Nickolas; Vogelstein, Bert; Vogelstein, Joshua T.; Douville, Christopher
  作者单位：Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins University; Columbia University; Johns Hopkins University; Howard Hughes Medical Institute; Johns Hopkins University; Johns Hopkins Medicine; Walter & Eliza Hall Institute; University of Melbourne; Peter Maccallum Cancer Center; University of Melbourne; Western Health; University of Technology Sydney; University of Technology Sydney; University of New South Wales Sydney; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins Medicine; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Johns Hopkins University; Johns Hopkins Medicine; McGill University; Johns Hopkins University; Johns Hopkins Medicine
  摘要：AI is now a cornerstone of modern dataset analysis. In many real world applications, practitioners are concerned with controlling specific kinds of errors, rather than minimizing the overall number of errors. For example, biomedical screening assays may primarily be concerned with mitigating the number of false positives rather than false negatives. Quantifying uncertainty in AI-based predictions, and in particular those controlling specific kinds of errors, remains theoretically and practical...
• Long-term climate warming weakens positive plant biomass responses globally AI翻译
  作者：Dang, Pengfei; Ciais, Philippe; Gao, Jiaxin; Zhu, Yunxiao; Xue, Jiquan; Qin, Xiaoliang; Ros, Gerard H.
  作者单位：Northwest A&F University - China; Universite Paris Saclay; Wageningen University & Research
  摘要：Carbon sequestration through plant biomass responses to global warming plays a vital role in mitigating climate change, but recent evidence suggests that this effect diminishes in the long term. To investigate the effect of warming duration on plant biomass responses, we analyzed a global dataset of 2,291 paired observations, revealing that warming increased overall aboveground plant biomass by 9.4% and belowground biomass by 2.6%. However, as the warming duration increased, the positive plant...
• Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic (vol 103, pg 14907, 2006) AI翻译
  作者：Kuroda, Junya; Puthalakath, Hamsa; Cragg, Mark S.; Kelly, Priscilla N.; Bouillet, Philippe; Huang, David C. S.; Kimura, Shinya; Ottmann, Oliver G.; Druker, Brian J.; Villunger, Andreas; Roberts, Andrew W.; Strasser, Andreas