34期

最新文章

• GATA3 promotes ferroptosis resistance by repressing integrin β1 signaling AI翻译
  作者：Karner, Emmet R.; Wang, Mengdie; Goel, Hira Lal; Mercurio, Arthur M.
  作者单位：University of Massachusetts System; University of Massachusetts Worcester; UMass Chan Medical School
  摘要：a timely issue that has significant ramifications for biology and pathology. We investigated these mechanisms in the context of breast cancer where tumors are composed of diverse populations of cancer cells that differ in their ferroptosis sensitivity. Using single- cell RNA- sequencing, we determined that cancer cell populations with luminal differentiation are more resistant to ferroptosis than other cells within a heterogeneous tumor. Subsequent bioinformatic analysis and experimentation re...
• Action-type mapping principles extend beyond evolutionarily conserved actions, even in people born without hands AI翻译
  作者：Martinez-Addiego, Florencia; Liu, Yuqi; Moon, Kyungji; Shytle, Elizabeth; Amaral, Lenia; O'Brien, Caroline; Sen, Sriparna; Riesenhuber, Maximilian; Culham, Jody C.; Striem-Amit, Ella
  作者单位：Georgetown University; Chinese Academy of Sciences; Center for Excellence in Brain Science and Intelligence Technology, CAS; Georgetown University; Universidade de Coimbra; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Georgetown University; Western University (University of Western Ontario)
  摘要：How are actions represented in the motor system? Although the sensorimotor system is broadly organized somatotopically, higher-level sensorimotor areas encode action-type information for reaching and grasping actions-regardless of the acting body part. Does the brain similarly support generalization across acting body parts for more evolutionarily recent actions, such as tool-use? We tested whether there is a body-part-independent action-type organization in sensorimotor areas by examining fMR...
• Germline variants in UHRF1 are associated with multilocus imprinting disturbance in humans and mice AI翻译
  作者：Ochoa, Eguzkine; Zvetkova, Ilona; Lee, Sunwoo Liv; Takahashi, Nozomi; Leung, Benoit Lan-; Hobson, Emma; Issa, Mahmoud; Yngvadottir, Bryndis; Docquier, France; Rodger, Fay; Hall, Dounia Foster-; Clark, Graeme; Toribio, Ana; Martin, Ezequiel; Bottolo, Leonardo; Ferguson-Smith, Anne C.; Fischle, Wolfgang; Constancia, Miguel; Maher, Eamonn R.
  作者单位：University of Cambridge; University of Cambridge; University of Cambridge; University of Leeds; Chapel Allerton Hospital; University of Cambridge; University of Cambridge; Alan Turing Institute; MRC Biostatistics Unit; University of Cambridge; King Abdullah University of Science & Technology; University of Cambridge; Aston University
  摘要：The investigation of congenital imprinting disorders (CIDs) provides opportunities to elucidate the molecular mechanisms and role of genomic imprinting in development and human disease. Beckwith-Wiedemann spectrum (BWSp) is a prototypic CID resulting from genetic and epigenetic alterations of imprinted genes at chromosome 11p15.5. In up to a quarter of individuals with BWSp, the epigenetic alterations are not confined to 11p15.5 imprinting control regions but also involve other imprinted gene ...
• The functional dynamics of FicD's TPR domain are modulated the interaction with ATP and BiP AI翻译
  作者：Runge, Svenja; Bilgen, Ecenaz; Magni, Andrea; Bonollo, Giorgio; Colombo, Giorgio; Itzen, Aymelt; Lamb, Don C.
  作者单位：University of Hamburg; University Medical Center Hamburg-Eppendorf; University of Munich; University of Munich; University of Pavia; University of Hamburg; University Medical Center Hamburg-Eppendorf
  摘要：The human Fic enzyme FicD plays an important role in regulating the Hsp70 homolog BiP in the endoplasmic reticulum: FicD reversibly modulates BiP's activity through attaching an adenosine monophosphate to the substrate binding domain. This reduces BiP's chaperone activity by shifting it into a conformation with reduced substrate affinity. Crystal structures of FicD in the apo, adenosine triphosphate (ATP)-bound, and BiP-bound states suggested significant conformational variability in the tetra...
• Factors underlying a latitudinal gradient in the S/G lignin monomer ratio in natural poplar variants AI翻译
  作者：Zhu, Weiwei; Zhang, Jin; Prabhakar, Pradeep Kumar; Chan, Yen On; Weber, Rachel A.; Shu, Mengjun; Panzade, Ganesh; Cooper, Connor J.; Davidson, Russell B.; Parks, Jerry M.; Urbanowicz, Breeanna R.; Tuskan, Gerald A.; Joshi, Trupti; Dixon, Richard A.; Muchero, Wellington; Barros, Jaime
  作者单位：University of Missouri System; University of Missouri Columbia; Zhejiang A&F University; United States Department of Energy (DOE); Oak Ridge National Laboratory; United States Department of Energy (DOE); Oak Ridge National Laboratory; University System of Georgia; University of Georgia; University System of Georgia; University of Georgia; University of Missouri System; University of Missouri Columbia; University of Missouri System; University of Missouri Columbia; University of North Texas System; University of North Texas Denton
  摘要：The chemical composition of wood plays a pivotal role in the adaptability and structural integrity of trees. However, few studies have investigated the environmental factors that determine lignin composition and its biological significance in plants. Here, we examined the lignin syringyl-to-guaiacyl (S/G) ratio in members of a Populus trichocarpa population sourced from their native habitat and conducted a genome wide association study to identify genes linked to lignin formation. Our results ...
• Generative AI without guardrails can harm learning: Evidence from high school mathematics (vol 122, e2422633122, 2025) AI翻译
  作者：Bastani, Hamsa; Bastani, Osbert; Sungu, Alp; Ge, Haosen; Kabakci, Ozge; Mariman, Rei
  作者单位：University of Pennsylvania; University of Pennsylvania
• Identifying fish populations prone to abrupt shifts via dynamical footprint analysis AI翻译
  作者：Cano, Alejandro V.; Jensen, Olaf P.; Dakos, Vasilis
  作者单位：Centre National de la Recherche Scientifique (CNRS); Institut de Recherche pour le Developpement (IRD); Universite de Montpellier; University of Wisconsin System; University of Wisconsin Madison
  摘要：Fish population biomass fluctuates through time in ways that may be either gradual or abrupt. While abrupt shifts in fish population productivity have been shown to be common, they are rarely integrated into stock assessment or fishery management, in part because of the difficulty of predicting when abrupt shifts may occur and which stocks are prone to such shifts. In this study, we address the latter challenge by designing a mechanism-agnostic context-specific approach that is based on exploi...
• Future winters promise less snow, more rain. Nobody's prepared AI翻译
  作者：McDermott, Amy
• Hippocampal mismatch signals are based on episodic memories and not schematic knowledge AI翻译
  作者：Varga, Dominika K.; Raykov, Petar P.; Jefferies, Elizabeth; Ben-Yakov, Aya; Bird, Chris M.
  作者单位：University of Sussex; University of Sussex; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); University of Cambridge; University of York - UK; Hebrew University of Jerusalem
  摘要：Prediction errors drive learning by signaling mismatches between expectations and reality, but the neural systems supporting these computations remain debated. The hippocampus is implicated in mismatch detection, yet it is not known whether it signals mismatches with episodic memories or generalized knowledge. Across three functional Magnetic Resonance Imaging (fMRI) experiments, we show that the hippocampus selectively responds to mismatches with episodic memories of specific events. In contr...
• FADDDED filaments coordinate complex IIa assembly during TNF-induced apoptosis AI翻译
  作者：Chen, Ying; Huynh, Vinh Thang; Lai, Lihua; Liu, Ping; Li, Tongyang; Tan, Yaw Bia; Chew, Che Shin; Velazquez, Amhed Missael Vargas; Samsudin, Firdaus; Marzinek, Jan K.; Bond, Peter J.; Wu, Bin; Luo, Dahai; Tergaonkar, Vinay
  作者单位：Agency for Science Technology & Research (A*STAR); A*STAR - Institute of Molecular & Cell Biology (IMCB); Nanyang Technological University; Nanyang Technological University; Agency for Science Technology & Research (A*STAR); A*STAR - Bioinformatics Institute (BII); National University of Singapore; Nanyang Technological University; National Centre for Infectious Diseases Singapore; National University of Singapore
  摘要：Extrinsic apoptosis is initiated by signaling from death receptors, leading to the assembly of RIPK1, FADD, and caspase-8 complex. Subsequently, caspase-8 forms a filamentous structure through the oligomerization of its tandem death effector domain (tDED), resulting in caspase activation and cell death. Although the DED of FADD (FADDDED) is homologous to the tDEDs of caspase-8 (casp8tDED) and both oligomerize to function, the functional form of FADDDED oligomer in extrinsic apoptosis remains u...