Action-type mapping principles extend beyond evolutionarily conserved actions, even in people born without hands

• 成果类型: Article
• 署名作者: Martinez-Addiego, Florencia; Liu, Yuqi; Moon, Kyungji; Shytle, Elizabeth; Amaral, Lenia; O'Brien, Caroline; Sen, Sriparna; Riesenhuber, Maximilian; Culham, Jody C.; Striem-Amit, Ella
• 署名单位: Georgetown University; Chinese Academy of Sciences; Center for Excellence in Brain Science and Intelligence Technology, CAS; Georgetown University; Universidade de Coimbra; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Georgetown University; Western University (University of Western Ontario)
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-8924
• 发表日期: 2025-08-26
• 关键词: posterior parietal cortex; effector-specific organization; functional connectivity mri; primary motor cortex; tool-use; human frontoparietal; cortical networks; premotor cortex; motion artifact; visual-cortex

摘要

How are actions represented in the motor system? Although the sensorimotor system is broadly organized somatotopically, higher-level sensorimotor areas encode action-type information for reaching and grasping actions-regardless of the acting body part. Does the brain similarly support generalization across acting body parts for more evolutionarily recent actions, such as tool-use? We tested whether there is a body-part-independent action-type organization in sensorimotor areas by examining fMRI responses for tool-use actions that participants performed with their hands or feet. We additionally included individuals born without hands to test whether hand sensorimotor experience is necessary for the development of this action-type organization. Across analyses, we found a consistent dissociation in the motor system. The primary sensorimotor cortices encoded ent of the body part for both groups. Together, our results suggest that the hierarchical organization of the motor system is not dependent on a long evolutionary history of an action. Further, this organization is not dependent on an individual's manual sensorihandlessness follows the hierarchical organization of the intact cortex, revealing the