36期

最新文章

• Preschool teachers provide fewer participation opportunities to working-class students than those from more privileged backgrounds AI翻译
  作者：Doyle, Lewis; Cimpian, Andrei; Goupil, Louise; Goudeau, Sebastien
  作者单位：Universite de Poitiers; Centre National de la Recherche Scientifique (CNRS); University of Surrey; New York University; Universite Savoie Mont Blanc; Centre National de la Recherche Scientifique (CNRS); Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA)
  摘要：Social class disparities exist from the earliest stages of education. Research has suggested that class-based differences in factors such as socialization practices and access to resources partly explain this phenomenon, but less work has explored whether teachers' practices also exacerbate these inequalities. Using whole-class observations of 63 preschool classroom discussions (N = 226 students, 10 teachers), we coded 7,941 student participation attempts and subsequent responses from teachers...
• Structural insights into the substrate uptake and inhibition of the human creatine transporter (hCRT) AI翻译
  作者：Yuan, Xinyi; Yin, Jian; Liu, Chang; Chen, Xudong; Chen, Meiying; Wang, Yixue; Yang, Zi; Wang, Yue; Jiang, Li; Zhou, Niyun; Wang, Xiaojuan; Liu, Botong; Ma, Zhaoqi; Wang, Kaiyan; Li, Hongen; Zhang, Sensen; Shang, Yongfeng; Yang, Maojun
  作者单位：Hangzhou Normal University; Hangzhou Normal University; Peking University; Tsinghua University; Beijing Life Science Academy; Tsinghua University; Capital Medical University; China Agricultural University; Air Force Medical University; Air Force Medical University; Chinese People's Liberation Army General Hospital
  摘要：Creatine plays a vital role in cellular energy production and adenosine triphosphate (ATP) homeostasis and has also been identified as a neurotransmitter in the mammalian brain. Creatine is transported into cells by the human creatine transporter Mutations in hCRT cause cerebral creatine deficiency syndrome 1, a neurological disorder marked by intellectual disability, speech delay, and seizures. Beyond its role in the brain and muscle, hCRT is highly expressed in metabolically active tumors. M...
• Inflammation awakens dormant cancer cells by modulating the epithelial-mesenchymal phenotypic state AI翻译
  作者：Zhang, Jingwei; Zhang, Jingwen; Han, Longfei; Wu, Shiyi; Li, Jie; Eaton, Elinor Ng; Yuan, Bingbing; Reinhardt, Ferenc; Li, Hao; Strasser, Patrick C.; Das, Sunny; Donahera, Joana Liu; Khalila, Md Imtiaz; Jiang, Haiping; Deuschel, Alexander; Lin, Danni; Sebastiany, Carolin; Maranga, Mariana; Shubitidze, Salome; Liu, Xiaofei; Lambert, Arthur W.; Zhang, Yun; Liu, Yana; Sui, Lufei; Elmiligy, Sarah; Pozza, Umberto; Gunsay, Rauf; Mishra, Ranjan; Velarde, Jose; Iyer, Sonia; Henra, Whitney S.; Weiskopf, Kipp; Fen, Guihai; Oni, Tobiloba E.; Watnick, Randolph S.; Li, Xin; Weinberg, Robert A.
  作者单位：Massachusetts Institute of Technology (MIT); Whitehead Institute; Chinese Academy of Sciences; Nanjing Institute of Geology & Paleontology, CAS; Institute of Zoology, CAS; Chinese Academy of Sciences; Beijing Institute for Stem Cell & Regenerative Medicine; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Nankai University; Chinese Academy of Medical Sciences - Peking Union Medical College; Cancer Institute & Hospital - CAMS; Peking Union Medical College; Chinese Academy of Medical Sciences - Peking Union Medical College; Cancer Institute & Hospital - CAMS; Peking Union Medical College; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard Medical School; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; University of Bergen; University of Bergen; Haukeland University Hospital; Massachusetts Institute of Technology (MIT)
  摘要：The awakening of dormant disseminated cancer cells appears to be responsible for the clinical relapses of patients whose primary tumors have been successfully cured months and even years earlier. In the present study, we demonstrate that dormant breast cancer cells lodged in the lungs reside in a highly mesenchymal, nonproliferative phenotypic state. The awakening of these cells is not triggered by a cancer peutic agent bleomycin effectively awakens dormant cancer cells, providing useful model...
• Mutations in the circadian cycle drive adaptive plasticity in cyanobacteria AI翻译
  作者：Mendana, Alfonso; Santos-Merino, Maria; Gutierrez-Lanza, Raquel; Dominguez-Quintero, Marina; Medina-Mendez, Juan Manuel; Gonzalez-Guerra, Ana; Campa, Victor; Baez, Miguel; Ducos-Galand, Magaly; Lopez-Igual, Rocio; Volke, Daniel C.; Gugger, Muriel; Nikel, Pablo I.; Mazel, Didier; de la Cruz, Fernando; Fernandez-Lopez, Raul
  作者单位：Michigan State University; University of Sevilla; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto de Bioquimica Vegetal y Fotosintesis (IBVF); Consejo Superior de Investigaciones Cientificas (CSIC); Universidad de Cantabria; CSIC - Instituto de Biomedicina y Biotecnologia de Cantabria (IBBTEC); Universite Paris Cite; Pasteur Network; Centre National de la Recherche Scientifique (CNRS); Institut Pasteur Paris; CNRS - National Institute for Biology (INSB); Technical University of Denmark; Universite Paris Cite; Pasteur Network; Institut Pasteur Paris
  摘要：Circadian clocks allow organisms to anticipate daily fluctuations in light and temperature, but how this anticipatory role promotes adaptation to different environments remains poorly understood. Here, we subjected the cyanobacterium Synechococcus elongatus PCC 7942 to a long-term evolution experiment under high light, high temperature, and elevated CO2 levels. After 1,200 generations, we obtained a strain exhibiting a 600% increase in growth rate. Whole-genome sequencing revealed three mutati...
• Rethinking early- life pathogen exposure: Lessons from a natural experiment controlling hookworms AI翻译
  作者：Schofield, Heather
  作者单位：Cornell University
• 9,000-year- old barley consumption in the foothills of central Asia AI翻译
  作者：Zhou, Xinying; Spengler, Robert N.; Sayfullaev, Bahediyoh; Mutalibjon, Khasanov; Ma, Jian; Liu, Junchi; Shen, Hui; Zhao, Keliang; Chen, Guanhan; Wang, Jian; Stidham, Thomas A.; Xu, Hai; Zhang, Guilin; Yang, Qingjiang; Hou, Yemao; Ma, Jiacheng; Kambarov, Nasibillo; Jiang, Hongen; Maksudov, Farhod; Goldstein, Steven; Wang, Jianxin; Fuller, Dorian Q.; Li, Xiaoqiang
  作者单位：Chinese Academy of Sciences; Institute of Vertebrate Paleontology & Paleoanthropology, CAS; Northwest University Xi'an; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Max Planck Society; Academy of Sciences of Uzbekistan; Tianjin University; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; University of London; University College London
  摘要：Scholars are increasingly favoring models for the origins of agriculture that involve a protracted process of increasing interdependence within a series of mutualistic relationships between humans and plants, as opposed to a rapid single event or innovation. Nonetheless, these scholars continue to debate over when people first started foraging for grass seeds, when they began to readily utilize sickles, how prominent the early selection pressures were, and when the first traits of domesticatio...
• Manipulating anthracyclines for deeper tissue penetration and implications for glycolytic tissues AI翻译
  作者：Abels, Erik R.; ter Linden, Esther; Rohling, Jos H. T.; Voortman, Lennard M.; Janssen, Lennert; Hornsveld, Marten; Overkleeft, Herman S.; van der Zanden, Sabina Y.; Broekman, Marike L. D.; Neefjes, Jacques
  作者单位：Leiden University - Excl LUMC; Leiden University; Leiden University Medical Center (LUMC); Leiden University; Leiden University - Excl LUMC; Leiden University Medical Center (LUMC); Leiden University; Leiden University - Excl LUMC; Leiden University; Leiden University - Excl LUMC; Leiden University Medical Center (LUMC); Haaglanden Medical Center
  摘要：How drugs penetrate tissues is poorly understood yet important, since drugs that fail to reach their target will be ineffective. We followed the fate of anthracycline cancer drugs at high resolution by exploiting their intrinsic fluorescence. In a cell-based spheroid model, the soluble compound fluorescein penetrates the entire spheroid, unlike hydrophobic fluorescent lipids, which only enter the outermost cell layer. Anthracyclines have intermediate hydrophobicity. They enter the nucleus of a...
• Resurfacing promotes antibacterial activity of a lipid A-binding nanobody AI翻译
  作者：O'Donnell, Angela C.; Wang, Xun; Kaderabkova, Nikol; Groover, Kyra E.; Perez, Bethany C.; Helms, Amanda; Brodbelt, Jennifer S.; Mavridou, Despoina A. I.; Davies, Bryan W.
  作者单位：University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; United States Department of Energy (DOE); Lawrence Livermore National Laboratory
  摘要：Nanobodies have been pursued as candidates for antimicrobial design due to their small size and versatile binding capacities, but direct antibacterial activity of a nano-body has yet to be described. Here, we employed a bacterial surface display platform to screen a synthetic library of nanobody variants for antimicrobial potential. We identified a candidate that binds the essential lipid A component of gram-negative lipopolysaccharide. Nonetheless, this nanobody required a weakened outer memb...
• Testis expressed 50 is essential for maintaining sperm acrosome integrity during epididymal transit AI翻译
  作者：Haga, Saori; Nozawa, Kaori; Abbasi, Ferheen; Kent, Katarzyna; Nagasawa, Naoko; Endo, Tsutomu; Miyata, Haruhiko; Ikawa, Masahito; Matzuk, Martin M.; Fujihara, Yoshitaka
  作者单位：National Cerebral & Cardiovascular Center - Japan; University of Osaka; University of California System; University of California Davis; Baylor College of Medicine; University of Tokyo; University of Osaka; University of Tokyo
  摘要：In mammals, sperm formation is completed in the seminiferous tubules within the testis, and sperm maturation occurs during the epididymal transit of the spermatozoa. Sperm morphology drastically changes when abnormal spermatozoa migrate from the testis to the epididymis. Detailed molecular mechanisms for sperm survival in the epididymis have not been determined yet. Globozoospermia is a cause of male infertility and is characterized by round-headed spermatozoa without acrosomes, an abnormal sp...
• Procollagen IIA mediates positive feedback control of the mouse cardiogenic transcriptional network AI翻译
  作者：Leung, Alan W.; Wong, Sandra Y.; Zhang, Janet C.; Leung, Keith K. H.; Dung, Nelson W. F.; Shang, Catherine A.; Prall, Owen W.; Nim, Hieu T.; See, Michael; Ramialison, Mirana; Chan, Danny; Mohun, Timothy J.; Harvey, Richard P.; Tam, Patrick P. L.; Cheah, Kathryn S. E.
  作者单位：University of Hong Kong; University of Hong Kong; Francis Crick Institute; Victor Chang Cardiac Research Institute; Murdoch Children's Research Institute; University of Melbourne; University of Melbourne; Monash University; Australian Regenerative Medicine Institute; Monash University; University of New South Wales Sydney; University of New South Wales Sydney; University of Sydney; Children's Medical Research Institute - Australia; University of Sydney
  摘要：Cardiogenesis relies on the integrated interplay between cardiac transcription factors and signaling pathways. Here, we uncover a role for type IIA procollagen (IIA), an extracellular matrix (ECM) protein encoded by an alternatively spliced Col2a1 transcript, encoding a N-terminal cysteine-rich domain, as a critical regulator in a cardiac gene regulatory feedback loop. The cysteine-rich domain of IIA protein was previously reported to interact with bone morphogenetic proteins (BMPs) and transf...