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作者：Li, Xiao - Jun; Morgan, Charles; Duy, Phan Q.; Evsen, Lale; Hao, Le T.; Machavoine, Roxane; Belhous, Kahina; Ernest, Sylvain; Denoyelle, Francoise; Mignot, Cyril; Brioude, Frederic; Parodi, Marine; Li, Lin; Huang, He; Ponniah, Prathamesh T. Nadar; Kolanus, Waldemar; Kahle, Kristopher T.; Marlin, Sandrine; Doetzlhofer, Angelika
作者单位：Johns Hopkins University; Johns Hopkins Medicine; Xi'an Jiaotong University; Yale University; Yale University; Yale University; Yale University; Universite Paris Cite; Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Saint-Louis - APHP; Hopital Universitaire Necker-Enfants Malades - APHP; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite; Universite Paris Cite; Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Saint-Louis - APHP; Hopital Universitaire Necker-Enfants Malades - APHP; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Saint-Louis - APHP; Hopital Universitaire Necker-Enfants Malades - APHP; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Sorbonne Universite; Hopital Universitaire Saint-Louis - APHP; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Sorbonne Universite; Hopital Universitaire Saint-Louis - APHP; Hopital Universitaire Armand-Trousseau - APHP; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Sorbonne Universite; Hopital Universitaire Saint-Louis - APHP; Assistance Publique Hopitaux Paris (APHP); Sorbonne Universite; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite; Hopital Universitaire Saint-Louis - APHP; Hopital Universitaire Armand-Trousseau - APHP; University of Bonn; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Johns Hopkins University; Johns Hopkins Medicine; University of Sydney; Kolling Institute of Medical Research
摘要：The RNA-binding protein TRIM71 is essential for brain development, and recent genetic studies in humans have identified TRIM71 as a risk gene for congenital hydrocephal-us (CH). Here, we show that monoallelic missense mutations in TRIM71 are associated with hearing loss (HL) and inner ear aplasia in humans. Utilizing conditional Trim71 knockout mice carrying a CH and HL-associated mutation, we demonstrate that loss of TRIM71 function during early otic development (embryonic day 9 to 10) causes...
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作者：Sands, Mark S.; Grubb, Jeffrey H.; Vogler, Carole A.; Waheed, Abdul; Montano, Adriana M.
作者单位：Washington University (WUSTL); Saint Louis University; Saint Louis University; Saint Louis University
摘要：William S. Sly, MD (1932-2025) was a biochemical geneticist who received his medical degree from Saint Louis University. He received additional training at the NIH with several members of the National Academy of Science and Nobel Prize winner Marshall Nirenberg. He is best known for discovering mucopolysaccharidosis type VII and developing a Food and Drug Administration-approved treatment for it. He served in several long-term leadership roles and won many accolades, including the Passano Foun...
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作者：Xu, Hao; Li, Yucong; Yang, Ling; Li, Nan; Lei, Kai
作者单位：Zhejiang University; Westlake University; Westlake Laboratory; Westlake University; Fudan University
摘要：The role of induced gene expression is crucial for tissue regeneration. The transient regenerative cellular state that discriminates between missing-tissue and non-missing-tissue injuries remains to be fully elucidated. In this study, we identified a homolog of Platelet-Derived Growth Factor (PDGF), named pdgf-like (pdgfl), in the planarian Schmidtea mediterranea. This gene exhibits inducible expression following missing-tissue injury in a back-and-forth manner between myosin+ muscular cells a...
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作者：Chen, Xue- Wei-Jie; Zhang, Zhou; Pan, Miao- Jun; Liu, Yang; Li, Chang-Lin; Zhou, Yan Gen; Li, Li; Dong, Xuan; Dong, Yun-Wei; Li, Jing-Yu; Liu, Su-Mei; Wang, Xiao-Nan; Tian, Shuang- Jie; Liu, Yi; Zhang, Ji- Hong; Qiu, Yan- Guo; Wang, Xue-Gang; Cai, Wei- Jun; Tian, Xiang - Li; Kao, Shuh- Ji; Dong, Shuang- Lin
作者单位：Ocean University of China; Ocean University of China; Hainan Tropical Ocean University; Ocean University of China; Chinese Academy of Fishery Sciences; Yellow Sea Fisheries Research Institute, CAFS; University of Delaware; Hainan University
摘要：Bivalve farming, a vital component of global aquaculture, has been proposed as a potential marine carbon dioxide removal (mCDR) strategy, yet its role remains contentious. Using field mesocosms, we demonstrate that oyster filter- feeding enhances mCDR by accelerating the formation of particulate and dissolved organic carbon in the water column and promoting organic carbon deposition in sediments. This process shifts the water column toward a more autotrophic and alkaline state, effectively seq...
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作者：Tapinova, Olga; Finkelman, Tal; Reitich-Stolero, Tamar; Paz, Rony; Tal, Assaf; Gov, Nir S.
作者单位：Weizmann Institute of Science; Weizmann Institute of Science; Tel Aviv University
摘要：Humans and other organisms make decisions choosing between different options, with the aim of maximizing the reward and minimizing the cost. The main theoretical framework for modeling the decision-making process has been based on the highly successful drift-diffusion model, which is a simple tool for explaining many aspects of this process. However, recent observations challenge this model. It was found that inhibitory tone increases during situations of difficult discrimination tasks, but th...
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作者：Willcox, Alexandra C.; Gobillot, Theodore A.; Kikawa, Caroline; Baumgarten, Nell E.; Stoddard, Caitlin I.; Sung, Kevin; Bhattacharya, Tamanash; Freeman, Tiia S.; Marceau, Joshua; Humes, Daryl; Overbaugh, Julie
作者单位：Fred Hutchinson Cancer Center; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Fred Hutchinson Cancer Center; Fred Hutchinson Cancer Center; University of Pennsylvania; Pennsylvania Medicine
摘要：Zika virus (ZIKV) has caused multiple human outbreaks, with more recent epidemics associated with severe outcomes in infants. Today, ZIKV is endemic to many countries and presents a persistent threat for future epidemics. The host innate immune proteins that regulate ZIKV replication are incompletely defined. We developed a CRISPR knockout screen to identify host factors that impact ZIKV replication, resulting in the finding of angiomotin-like protein 2 (AMOTL2), a protein that inhibits ZIKV b...
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作者：Loh, Wen Wei; Ren, Dongning
作者单位：Maastricht University; Maastricht University Medical Centre (MUMC); Maastricht University
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作者：O'Dea, Aaron; Sellers, Andrew J.; Perez- Medina, Carmen; Diaz, Javier Pardo; Bloise, Alexandra Guzman; Pohlker, Christopher; Chilinski, Michal T.; Aardema, Hedy M.; Cybulski, Jonathan D.; Heins, Lena; Paton, Steven R.; Slagter, Hans A.; Schiebel, Ralf; Haug, Gerald H.
作者单位：Smithsonian Institution; Smithsonian Tropical Research Institute; Secretaria Nacional de Ciencia, Tecnologia e Innovacin (SENACYT); Max Planck Society; University of Warsaw; Max Planck Society; University of Hong Kong
摘要：The Gulf of Panama's (GOP) seasonal upwelling system has consistently delivered cool, nutrient-rich waters via northerly trade winds every January-April for at least 40 y. Here, we document the failure of this normally highly predictable phenomenon in 2025. Data suggest that the cause was a reduction in Panama wind-jet frequency, duration, and strength, possibly related to the Intertropical Convergence Zone (ITCZ) position during the 2024-2025 La Ni & ntilde;a, though the mechanisms remain unc...
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作者：Qiu, Jiehua; Cao, Xiuxiu; Shi, Huanbin; Chen, Zhengting; Zhang, Xiaoyu; Cao, Zijian; Huang, Dongmei; Wen, Hui; Chen, Ya; Kou, Yanjun
作者单位：Chinese Academy of Agricultural Sciences; China National Rice Research Institute, CAAS; Hubei University
摘要：As global climate change exacerbates extreme heat events, the interplay between heat stress and blast disease resistance in rice remains poorly understood. In this study, through integrated transcriptome profiling and systematic phenotyping of mutants in several thermosensory pathways, we identified HsfA1 as a positive regulator of heat priming-enhanced blast resistance in rice. Systematic analysis of microRNA (miRNA) dynamics, bioinformatics prediction, and RNA pull-down experiments revealed ...
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作者：Hou, Mingzhuang; Ma, Yifan; Deng, Yaoge; Wu, Yubin; Zhu, Yanrun; Liu, Yang; Li, Xiaoping; Yu, Lili; He, Zirui; Wang, Yifan; Dong, Shiyan; Xia, Xiaowei; Yu, Jianfeng; Yu, Chenqi; Kang, Kang; Lu, Yingjie; Sun, Lili; Kim, Betty Y. S.; Yuan, Yuan; Zhang, Yijian; Jiang, Wen; Zhu, Xuesong
作者单位：Soochow University - China; Soochow University - China; University of Texas System; UTMD Anderson Cancer Center; University of Macau; East China University of Science and Technology; East China University of Science and Technology; University of Texas System; UTMD Anderson Cancer Center; Nanjing Medical University
摘要：Osteoarthritis is a prevalent joint disease in the aging population. The hallmark of osteoarthritis is the degeneration of the joint cartilage, characterized by changes in chondrocytes including mitochondrial dysfunction. However, the precise mechanisms of how this affects chondrocyte homeostasis and whether such processes can be explored as therapeutic targets for osteoarthritis remain unclear. Here, we show that impaired mitochondrial function and disrupted cartilage matrix metabolism due to...
