36期

最新文章

• The molecular structure of the master growth regulator in plants emerges into the spotlight AI翻译
  作者：Yoshida, Hideki; Matsuoka, Makoto
  作者单位：Fukushima University
• Tumor-expressed GPNMB orchestrates Siglec-9+TAM polarization and EMT to promote metastasis in triple-negative breast cancer AI翻译
  作者：Cao, Thuy Linh Dang; Kawanishi, Kunio; Hashimoto, Sachie; Hengphasatporn, Kowit; Nagai-Okatani, Chiaki; Kimura, Takaharu; Abdelaziz, Mohammed; Shiratani, Rie; Poullikkas, Thanasis; Azmi, Nuriza Ulul; Baba, Masaki; Okita, Yukari; Watanabe, Yukihide; Bando, Hiroko; Yamazaki, Satoshi; Shigeta, Yasuteru; Kuno, Atsushi; Kato, Mitsuyasu
  作者单位：University of Tsukuba; Showa Medical University; University of Tsukuba; University of Tsukuba; National Institute of Advanced Industrial Science & Technology (AIST); University of Tsukuba; University of Tokyo; Egyptian Knowledge Bank (EKB); Sohag University; University of Tsukuba; Juntendo University; University of Tsukuba
  摘要：Metastasis remains the leading cause of cancer-related mortality, driven by complex interactions within the tumor microenvironment (TME). Tumor-associated macrophages (TAMs) play a pivotal role in metastatic progression, yet their molecular diversity and upstream regulators remain poorly defined. Glycoprotein nonmetastatic melanoma protein B (GPNMB), overexpressed in subsets of tumors including triple-negative breast cancer (TNBC), is implicated in epithelial-mesenchymal transition (EMT) and c...
• Collective behavior of flexicles AI翻译
  作者：Schonhofer, Philipp W. A.; Glotzer, Sharon C.
  作者单位：University of Michigan System; University of Michigan; University of Michigan System; University of Michigan
  摘要：In recent years the functionality of synthetic active microparticles has edged even closer to that of their biological counterparts. However, we still lack the understanding needed to recreate at the microscale key features of autonomous behavior exhibited by microorganisms or swarms of macroscopic robots. In this study, we propose a model for a three-dimensional deformable cellular composite particle consisting of self-propelled rod-shaped colloids confined within a flexible vesicle-represent...
• Origami frustration and its influence on energy landscapes of origami assemblies AI翻译
  作者：Zang, Shixi; Zhao, Tuo; Misseroni, Diego; Paulino, Glaucio H.
  作者单位：Princeton University; University of Trento; Princeton University
  摘要：Harnessing instabilities of multicomponent multistable structural assemblies can potentially lead to scalable and reversible functionalities, which can be enhanced by exploring frustration. For instance, standard Kresling origami cells exhibit nontunable intrinsic energy landscapes determined by their geometry and material properties, limiting their adaptability after fabrication. To overcome this limitation, we introduce frustration to enable fine-tuning of the energy landscape and resulting ...
• Ultracold cryogenic TEM with liquid helium and high stability AI翻译
  作者：Rennich, Emily; Sung, Suk Hyun; Agarwal, Nishkarsh; Gates, Maya; Kerns, Robert; Hovden, Robert; El Baggari, Ismail
  作者单位：Harvard University; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan
  摘要：Cryogenic transmission electron microscopy has revolutionized structural biology and materials science. To image below liquid nitrogen temperatures, various liquid helium stages have been constructed but have proven to be complex and unstable, making high-resolution imaging challenging. This problem is even more pronounced in side-entry specimen holders common on modern transmission electron microscopes. Here, we introduce an ultracold liquid helium transmission electron microscope side-entry ...
• Vacuum tunneling of vortices in two-dimensional 4He superfluid films AI翻译
  作者：Desrochers, M. J.; Marchand, D. J. J.; Stamp, P. C. E.
  作者单位：University of British Columbia; University of British Columbia
  摘要：At low temperature T we expect vacuum tunneling processes to occur in superfluid 4He films. We distinguish between extrinsic processes, in which single vortices nucleate by tunneling off boundaries in the system, and intrinsic processes, in which vortex/antivortex pairs nucleate far from boundaries. It is crucial to incorporate the varying effective mass of the vortex in tunneling calculations. The intrinsic processes are the superfluid analogue of the Schwinger mechanism in quantum field theo...
• Bouncing microdroplets on hydrophobic surfaces AI翻译
  作者：McLauchlan, Jamie; Walker, Jim S.; Sanjay, Vatsal; Jalaal, Maziyar; Reid, Jonathan P.; Squires, Adam M.; Souslov, Anton
  作者单位：University of Bath; University of Bristol; Durham University; University of Amsterdam; University of Bath; University of Cambridge
  摘要：Intuitively, slow droplets stick to a surface and faster droplets splash or bounce. However, recent work suggests that on nonwetting surfaces, whether microdroplets stick or bounce depends only on their size and fluid properties, but not on the incoming velocity. Here, we show using theory and experiments that even poorly wetting surfaces have a velocity-dependent criterion for bouncing of aqueous droplets, which is as high as 6 m/s for diameters of 30 to 50 mu m on hydrophobic surfaces such a...
• Joint models reveal human subcortical underpinnings of choice and learning behavior AI翻译
  作者：Miletic, Steven; Stevenson, Niek; Bazin, Pierre-Louis; Alkemade, Anneke; Isherwood, Scott J. S.; Trutti, Anne C.; Tse, Desmond H. Y.; Haberg, Asta K.; Forstmann, Birte U.
  作者单位：Leiden University - Excl LUMC; Leiden University; University of Amsterdam; Maastricht University; Norwegian University of Science & Technology (NTNU)
  摘要：Decision making and learning processes together enable adaptive strategic behavior. Animal studies demonstrated the importance of subcortical regions in these cognitive processes, but the human subcortical contributions remain poorly characterized. Here, we study choice and learning processes in the human subcortex, using a tailored ultra-high field 7T functional MRI protocol combined with joint models. Joint models provide unbiased estimates of brain-behavior relations by simultaneously inclu...
• Direct measurement of plume velocity to characterize point source emissions AI翻译
  作者：Eastwood, Michael L.; Thompson, David R.; Green, Robert O.; Fahlen, Jay E.; Adams, Taylor J.; Brandt, Adam R.; Brodrick, Philip G.; Chlus, Adam; Kort, Eric A.; Reuland, Frances; Thorpe, Andrew K.
  作者单位：California Institute of Technology; National Aeronautics & Space Administration (NASA); NASA Jet Propulsion Laboratory (JPL); University of Michigan System; University of Michigan; Stanford University
  摘要：An explosion of recent research uses remote imaging spectroscopy from aircraft and spacecraft to detect and quantify methane point source emissions. These instruments first map the methane enhancement field and then combine this information with the effective wind speed to estimate the source emission rate. This wind speed is typically the largest uncertainty in derived emission rates. It is often, by necessity, inferred from coarse-resolution meteorological reanalysis products which do not ma...
• Migration shapes senescence in a long-lived bird AI翻译
  作者：Cayuela, Hugo; Roques, Sebastien; Arnaud, Antoine; Germain, Christophe; Bechet, Arnaud; Champagnon, Jocelyn
  作者单位：Universite Lyon 1; VetAgro Sup; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Ecology & Environment (INEE); Universite Paul-Valery; Institut de Recherche pour le Developpement (IRD); Centre National de la Recherche Scientifique (CNRS); Universite de Montpellier; Universite PSL; Institut Agro; Ecole Pratique des Hautes Etudes (EPHE); Institut Agro Montpellier
  摘要：Each year, billions of animals migrate across the globe on diverse spatial and temporal scales. Migration behavior thus plays a fundamental role in the life cycle and Darwinian fitness of many organisms. While the influence of migration on early-life survival and reproduction is well documented, its effects on senescence (aging) in advanced age remain largely unexplored. Using a unique 44-y ring-resighting dataset from long-lived, partially migratory bird species, the Greater Flamingo (Phoenic...