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作者：Afzal, Junaid; Suhail, Yasir; Du, Wenqiang; Liu, Yamin; Ramasamy, Ramalakshmi; Liu, Zukai; Goyal, Ruchi; Novin, Ashkan; Suhail, Sameera; Maziarz, Jamie; Wali, Khadija; Robson, Paul; Wagner, Gunter P.; Kshitiz
作者单位：University of California System; University of California San Francisco; University of Connecticut; Jackson Laboratory; Yale University; Yale University
摘要：Coopetition is a term from game theory that describes a mix of cooperative and competitive behavior. The maternal-fetal interface (MFI) among eutherian mammals presents close interaction of two distinct individuals. These interactions have resulted in a remarkable diversity in MFI structure, often interpreted as the outcome of maternal-fetal conflict. Nevertheless, the fetus and the mother share evolutionary interests since 50% of fetal genes are maternal. In hemochorial species, characterized...
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作者：Ando, Jun; Murai, Kazue; Michiyuki, Tomoe; Takahashi, Ikuko; Iida, Tatsuya; Kogo, Yasushi; Toyoda, Masashi; Saito, Yuko; Murayama, Shigeo; Kurihara, Masanori; Watanabe, Rikiya
作者单位：RIKEN
摘要：Digital bioanalysis enables highly sensitive detection of biomolecules at the single-molecule level, making it a widely used technique in biomedical research. However, conventional approaches typically rely on fluorescence detection of single-enzyme reactions, which limits molecular selectivity and the ability to analyze multiple targets simultaneously. To address these limitations, we developed a digital bioanalysis platform based on surface-enhanced Raman scattering spectroscopy and microcha...
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作者：Mittal, Anshumali; Martin, Matthew F.; Provins, Laurent; Hall, Adrian; Ledecq, Marie; Wolff, Christian; Gillard, Michel; Horanyi, Peter S.; Coleman, Jonathan A.
作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; UCB Pharma SA
摘要：Brivaracetam (BRV) and levetiracetam (LEV) are antiseizure medications (ASMs); UCB-J is a PET tracer targeting synaptic vesicle protein 2A (SV2A); UCB7361 is closely related to padsevonil, an experimental anticonvulsant; while UCB1244283 acts as an allosteric modulator for BRV and LEV binding but not for these other ligands. The SV2A-BRV-UCB1244283 structure reveals how UCB1244283 allosterically enhances BRV binding by occupying an allosteric site near the primary binding site, preventing BRV ...
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作者：Adelmann, Charles H.; Venkatachalam, Avanthika; Huang, Lingjuan; Liu, Michelle; Germana, Sharon; Harry, Stefan A.; Rosen, Paul C.; Herron, Joshua; Tien, Pei- Chieh; Bar-Peled, Liron; Sabatini, David M.; Fisher, David E.
作者单位：Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Czech Academy of Sciences; Institute of Organic Chemistry & Biochemistry of the Czech Academy of Sciences
摘要：While it has been appreciated for decades that lysosomes can import cysteine, its significance for whole- organism physiology has remained uncertain. Recent work identified MFSD12 as a transmembrane protein required for cysteine import into lysosomes (and melanosomes), enabling genetic interrogation of this pathway. Here, we show that Mfsd12 knockout mice die between embryonic days 10.5 and 12.5, indicating that MFSD12 is essential for organogenesis. Mfsd12 loss results in the expression of ge...
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作者：Rowntree, Louise C.; Allen, Lilith F.; Hagen, Ruth R.; McQuilten, Hayley A.; Quadeer, Ahmed A.; Chaurasia, Priyanka; Kaewpreedee, Prathanporn; Lee, Kelly W. K.; Cohen, Carolyn A.; Petersen, Jan; Littler, Dene R.; Habel, Jennifer R.; Zhang, Wuji; Cheng, Samuel M. S.; Chan, Ken Ka Pang; Kwok, Janette S. Y.; Leung, Kathy S. M.; Wu, Joseph T.; Lee, Cheuk-Kwong; Davies, Jane; Pannaraj, Pia S.; Allen, E. Kaity; Thomas, Paul G.; Tosif, Shidan; Crawford, Nigel W.; Lappas, Martha; Thevarajan, Irani; Lewin, Sharon R.; Kent, Stephen J.; Juno, Jennifer A.; Bond, Katherine A.; Williamson, Deborah A.; Holmes, Natasha E.; Smibert, Olivia C.; Gordon, Claire L.; Trubiano, Jason A.; Kotsimbos, Tom C.; Cheng, Allen C.; Efstathiou, Claudia; Turtle, Lance; Thwaites, Ryan S.; Brightling, Christopher E.; Rossjohn, Jamie; McKay, Matthew R.; Tian, Jinmin; Liu, William Jun; Gao, George Fu; Xu, Jianqing; Sonehara, Kyuto; Ishii, Ken J.; Namkoong, Ho; Okada, Yukinori; Peiris, Malik; Hui, David S. C.; Poon, Leo L. M.; Doherty, Peter C.; Nguyen, Thi H. O.; Valkenburg, Sophie A.; Kedzierska, Katherine
作者单位：University of Melbourne; Peter Doherty Institute; Hong Kong University of Science & Technology; University of Melbourne; Monash University; Monash University; University of Hong Kong; University of Hong Kong; Chinese University of Hong Kong; Prince of Wales Hospital; Chinese University of Hong Kong; University of Hong Kong; University of Hong Kong; University of Hong Kong; Charles Darwin University; Menzies School of Health Research; Children's Hospital Los Angeles; University of California System; University of California Los Angeles; St Jude Children's Research Hospital; Murdoch Children's Research Institute; University of Melbourne; Royal Children's Hospital Melbourne; Royal Children's Hospital Melbourne; University of Melbourne; University of Melbourne; Peter Doherty Institute; University of Melbourne; Peter Doherty Institute; Melbourne Health; Royal Melbourne Hospital; Florey Institute of Neuroscience & Mental Health; Howard Florey Institute Affiliates; Monash University; University of Melbourne; Alfred Health; Melbourne Sexual Health Centre; Monash University; Victorian Infectious Diseases Reference Laboratory; University of Melbourne; Peter Doherty Institute; Melbourne Health; Royal Melbourne Hospital; University of St Andrews; Austin Research Institute; Florey Institute of Neuroscience & Mental Health; Howard Florey Institute Affiliates; Austin Research Institute; Florey Institute of Neuroscience & Mental Health; Howard Florey Institute Affiliates; University of Melbourne; Florey Institute of Neuroscience & Mental Health; Howard Florey Institute Affiliates; Austin Research Institute; Peter Maccallum Cancer Center; Peter Maccallum Cancer Center; Florey Institute of Neuroscience & Mental Health; Howard Florey Institute Affiliates; Florey Institute of Neuroscience & Mental Health; Howard Florey Institute Affiliates; Monash University; Monash University; Monash Health; Monash University; Monash University; Imperial College London; University of Liverpool; University of Leicester; Cardiff University; Chinese Center for Disease Control & Prevention; National Institute for Viral Disease Control & Prevention, Chinese Center for Disease Control & Prevention; Fudan University; Fudan University; University of Osaka; University of Tokyo; University of Tokyo; University of Osaka; Keio University; RIKEN; University of Osaka; Hokkaido University
摘要：Understanding host factors driving asymptomatic versus severe disease outcomes is of key importance if we are to control emerging and re-emerging viral infections. HLA-B*15:01 has been associated with asymptomatic SARS-CoV-2 infection in nonhospitalized individuals of European ancestry, with protective immunity attributed to preexisting cross-reactive CD8(+) T-cells directed against HLA-B*15:01-restricted Spike-derived S919-927 peptide (B15/S(919)(+)CD8(+) T-cells). However, fundamental questi...
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作者：Yao, Ze-Fan; Lim, Sujeung; Kuang, Yuyao; Lundqvist, Emil M.; Celt, Natalie; Chung, Caleb O.; Lee, Kathryn K.; Nguyen, Krystal; Le, Lanie; Tang, Sheng Wei; Milligan, Griffin M.; Kohl, Phillip; Sudarshan, Tarunya Rao; Li, Youli; Eguchi, Asuka; Paravastu, Anant K.; Zaragoza, Michael V.; Fishman, Dmitry A.; Ardona, Herdeline Ann M.
作者单位：University of California System; University of California Irvine; University of California System; University of California Irvine; University of California System; University of California Irvine; University of California System; University of California Santa Barbara; University System of Georgia; Georgia Institute of Technology; University of California System; University of California Irvine; University of California System; University of California Irvine; University System of Georgia; Georgia Institute of Technology
摘要：Charge and energy transport within living systems are fundamental processes that enable the autonomous function of excitable cells and tissues. To date, localized control of these transport processes has been enabled by genetic modification approaches to render light sensitivity to cells. Here, we present peptidic nanoassemblies as constituents of a cardiac biomaterial platform that leverages complementary sequence interactions to direct photoinduced energy transport at the cellular interface....
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作者：Gaffney, Anna D.; Liu, Dongxu; Samal, Deepanjali; Carotenuto, Angelo R.; Deseri, Luca; Fraldi, Massimiliano; Lee, Ka Yee C.; Pocivavsek, Luka; Nguyen, Nhung
作者单位：University of Chicago; University of Chicago; University of Naples Federico II; University of Trento; Universite PSL; Ecole Normale Superieure (ENS); Universite Paris Cite; University of Chicago; University of Chicago
摘要：Self-assembled thin films respond to external loads via surface instabilities that are critical to their functionality in both biology and technology. Lipid monolayers at the air-liquid interface are one such system. Tunability between out-of-plane buckling (e.g., folding) and in-plane relaxation (e.g., reorganization of lipid domains) in highly compressed lipid monolayers suggests underlying mechanistic generality. Yet, how in-plane relaxation occurs and how it is distinguished from folding r...
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作者：Sinclair, Alyssa H.; Cosme, Danielle; Lydic, Kirsten; Reinero, Diego A.; Mann, Michael E.; Falk, Emily B.
作者单位：University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania
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作者：Wang, Erin R.; Cho, Kevin; Harrison, Gregory A.; Smelyansky, Stephanie R.; Soni, Vijay; Smirnov, Asya; Mckee, Samuel R.; Ghabrial, George S.; Flentie, Kelly N.; Beatty, Wandy; Anyinam, Boatema Ofori -; Sarkar, Souvik; Hurtaux, Thomas; Loza, Liza; Almqvist, Fredrik; Doering, Tamara L.; Yang, Jason H.; Kiessling, Laura L.; Rhee, Kyu Y.; Patti, Gary J.; Stallings, Christina L.
作者单位：Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Massachusetts Institute of Technology (MIT); Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Massachusetts Institute of Technology (MIT); Ragon Institute; Cornell University; Weill Cornell Medicine; Rutgers University System; Rutgers University New Brunswick; Rutgers University Biomedical & Health Sciences; Rutgers University System; Rutgers University New Brunswick; Rutgers University Biomedical & Health Sciences; Umea University; Umea University; University of Wisconsin System; University of Wisconsin Madison
摘要：Isoniazid (INH) inhibits mycolic acid synthesis in Mycobacterium tuberculosis (Mtb) and is a cornerstone of treatment regimens against this deadly pathogen. However, over 10% of Mtb infections are INH-resistant. The compound C10 can sensitize clinically relevant INH-resistant mutants to killing by INH. Thus, understanding the mechanism of action for C10 could aid in designing new strategies for circumventing drug resistance. We find that C10 treatment reroutes carbon flux toward valine, drawin...
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作者：Rennich, Emily; Sung, Suk Hyun; Agarwal, Nishkarsh; Gates, Maya; Kerns, Robert; Hovden, Robert; El Baggari, Ismail
作者单位：Harvard University; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan
摘要：Cryogenic transmission electron microscopy has revolutionized structural biology and materials science. To image below liquid nitrogen temperatures, various liquid helium stages have been constructed but have proven to be complex and unstable, making high-resolution imaging challenging. This problem is even more pronounced in side-entry specimen holders common on modern transmission electron microscopes. Here, we introduce an ultracold liquid helium transmission electron microscope side-entry ...
