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作者：Jiang, Haowen; Tiche, Sarah Jane; He, Clifford Jiajun; Liu, Junyan; Bian, Fuyun; Jedoui, Mohamed; Forgo, Balint; Islam, Md Tauhidul; Zhao, Meng; Emengo, Pamela; He, Bo; Li, Yang; Li, Albert M.; Truong, Anh T.; Ho, Jestine; Simmermaker, Cathyrin; Yang, Yanan; Zhou, Meng-Ning; Hu, Zhen; Svensson, Katrin J.; Cuthbertson, Daniel J.; Hazard, Florette K.; Xing, Lei; Shimada, Hiroyuki; Chiu, Bill; Ye, Jiangbin
作者单位：Stanford University; Stanford University; Stanford University; Stanford University; University of California System; University of California Davis; Stanford University; Agilent Technologies
摘要：Reduced mitochondrial quality and quantity in tumors is associated with dedifferentiation and increased malignancy. However, it remains unclear how to restore mitochondrial quantity and quality in tumors and whether mitochondrial restoration can drive tumor differentiation. Our study shows that restoring mitochondrial function using retinoic acid (RA) to boost mitochondrial biogenesis and a mitochondrial uncoupler to enhance respiration synergistically drives neuroblastoma differentiation and ...
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作者：Robes, Jose Miguel D.; Liebergesell, Tashi C. E.; Beals, Delaney G.; Yu, Xinhui; Brazelton, William J.; Puri, Aaron W.
作者单位：United States Department of Energy (DOE); Oak Ridge National Laboratory; Utah System of Higher Education; University of Utah; Utah System of Higher Education; University of Utah; Utah System of Higher Education; University of Utah
摘要：Methane is a potent greenhouse gas and a target for near-term climate change mitigation. In many natural ecosystems, methane is sequestered by microbial communities, yet little is known about how constituents of methane-oxidizing communities interact with each other and their environment. This lack of mechanistic understanding is a common issue for many important microbial communities, but it is difficult to draw links between available sequencing information and the metabolites that govern co...
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作者：Schibler, Ueli; Sinturel, Flore; Naef, Felix; Gerber, Alan; Gatfield, David
作者单位：University of Geneva; Swiss School of Public Health (SSPH+); Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Vrije Universiteit Amsterdam; Vrije Universiteit Amsterdam; University of Amsterdam; University of Lausanne
摘要：In mammals, a hierarchically organized circadian timing system orchestrates daily rhythms of nearly all physiology. A master pacemaker in the brain's suprachiasmatic nucleus (SCN) synchronizes subsidiary clocks in most peripheral organs. By driving anabolic and catabolic cycles of proteins, lipids, and carbohydrates and by detoxifying endo-and xenobiotic components, the liver plays an important role in adapting the metabolic needs to rest-activity rhythms. In keeping with these functions, the ...
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作者：Chen, Xue- Wei-Jie; Zhang, Zhou; Pan, Miao- Jun; Liu, Yang; Li, Chang-Lin; Zhou, Yan Gen; Li, Li; Dong, Xuan; Dong, Yun-Wei; Li, Jing-Yu; Liu, Su-Mei; Wang, Xiao-Nan; Tian, Shuang- Jie; Liu, Yi; Zhang, Ji- Hong; Qiu, Yan- Guo; Wang, Xue-Gang; Cai, Wei- Jun; Tian, Xiang - Li; Kao, Shuh- Ji; Dong, Shuang- Lin
作者单位：Ocean University of China; Ocean University of China; Hainan Tropical Ocean University; Ocean University of China; Chinese Academy of Fishery Sciences; Yellow Sea Fisheries Research Institute, CAFS; University of Delaware; Hainan University
摘要：Bivalve farming, a vital component of global aquaculture, has been proposed as a potential marine carbon dioxide removal (mCDR) strategy, yet its role remains contentious. Using field mesocosms, we demonstrate that oyster filter- feeding enhances mCDR by accelerating the formation of particulate and dissolved organic carbon in the water column and promoting organic carbon deposition in sediments. This process shifts the water column toward a more autotrophic and alkaline state, effectively seq...
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作者：Loh, Wen Wei; Ren, Dongning
作者单位：Maastricht University; Maastricht University
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作者：O'Dea, Aaron; Sellers, Andrew J.; Perez- Medina, Carmen; Diaz, Javier Pardo; Bloise, Alexandra Guzman; Pohlker, Christopher; Chilinski, Michal T.; Aardema, Hedy M.; Cybulski, Jonathan D.; Heins, Lena; Paton, Steven R.; Slagter, Hans A.; Schiebel, Ralf; Haug, Gerald H.
作者单位：Smithsonian Institution; Smithsonian Tropical Research Institute; Secretaria Nacional de Ciencia, Tecnologia e Innovacin (SENACYT); Max Planck Society; University of Warsaw; Max Planck Society; University of Hong Kong
摘要：The Gulf of Panama's (GOP) seasonal upwelling system has consistently delivered cool, nutrient-rich waters via northerly trade winds every January-April for at least 40 y. Here, we document the failure of this normally highly predictable phenomenon in 2025. Data suggest that the cause was a reduction in Panama wind-jet frequency, duration, and strength, possibly related to the Intertropical Convergence Zone (ITCZ) position during the 2024-2025 La Ni & ntilde;a, though the mechanisms remain unc...
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作者：Qiu, Jiehua; Cao, Xiuxiu; Shi, Huanbin; Chen, Zhengting; Zhang, Xiaoyu; Cao, Zijian; Huang, Dongmei; Wen, Hui; Chen, Ya; Kou, Yanjun
作者单位：Chinese Academy of Agricultural Sciences; China National Rice Research Institute, CAAS; Hubei University
摘要：As global climate change exacerbates extreme heat events, the interplay between heat stress and blast disease resistance in rice remains poorly understood. In this study, through integrated transcriptome profiling and systematic phenotyping of mutants in several thermosensory pathways, we identified HsfA1 as a positive regulator of heat priming-enhanced blast resistance in rice. Systematic analysis of microRNA (miRNA) dynamics, bioinformatics prediction, and RNA pull-down experiments revealed ...
