36期

最新文章

• Restoring mitochondrial quantity and quality to reverse the Warburg effect and drive neuroblastoma differentiation AI翻译
  作者：Jiang, Haowen; Tiche, Sarah Jane; He, Clifford Jiajun; Liu, Junyan; Bian, Fuyun; Jedoui, Mohamed; Forgo, Balint; Islam, Md Tauhidul; Zhao, Meng; Emengo, Pamela; He, Bo; Li, Yang; Li, Albert M.; Truong, Anh T.; Ho, Jestine; Simmermaker, Cathyrin; Yang, Yanan; Zhou, Meng-Ning; Hu, Zhen; Svensson, Katrin J.; Cuthbertson, Daniel J.; Hazard, Florette K.; Xing, Lei; Shimada, Hiroyuki; Chiu, Bill; Ye, Jiangbin
  作者单位：Stanford University; Stanford University; Stanford University; Stanford University; University of California System; University of California Davis; Stanford University; Agilent Technologies
  摘要：Reduced mitochondrial quality and quantity in tumors is associated with dedifferentiation and increased malignancy. However, it remains unclear how to restore mitochondrial quantity and quality in tumors and whether mitochondrial restoration can drive tumor differentiation. Our study shows that restoring mitochondrial function using retinoic acid (RA) to boost mitochondrial biogenesis and a mitochondrial uncoupler to enhance respiration synergistically drives neuroblastoma differentiation and ...
• Inverse stable isotope probing-metabolomics (InverSIP) identifies an iron acquisition system in a methane- oxidizing bacterial community AI翻译
  作者：Robes, Jose Miguel D.; Liebergesell, Tashi C. E.; Beals, Delaney G.; Yu, Xinhui; Brazelton, William J.; Puri, Aaron W.
  作者单位：United States Department of Energy (DOE); Oak Ridge National Laboratory; Utah System of Higher Education; University of Utah; Utah System of Higher Education; University of Utah; Utah System of Higher Education; University of Utah
  摘要：Methane is a potent greenhouse gas and a target for near-term climate change mitigation. In many natural ecosystems, methane is sequestered by microbial communities, yet little is known about how constituents of methane-oxidizing communities interact with each other and their environment. This lack of mechanistic understanding is a common issue for many important microbial communities, but it is difficult to draw links between available sequencing information and the metabolites that govern co...
• Daily liver rhythms: Coupling morphological and molecular oscillations AI翻译
  作者：Schibler, Ueli; Sinturel, Flore; Naef, Felix; Gerber, Alan; Gatfield, David
  作者单位：University of Geneva; Swiss School of Public Health (SSPH+); Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Vrije Universiteit Amsterdam; Vrije Universiteit Amsterdam; University of Amsterdam; University of Lausanne
  摘要：In mammals, a hierarchically organized circadian timing system orchestrates daily rhythms of nearly all physiology. A master pacemaker in the brain's suprachiasmatic nucleus (SCN) synchronizes subsidiary clocks in most peripheral organs. By driving anabolic and catabolic cycles of proteins, lipids, and carbohydrates and by detoxifying endo-and xenobiotic components, the liver plays an important role in adapting the metabolic needs to rest-activity rhythms. In keeping with these functions, the ...
• Oyster farming acts as a marine carbon dioxide removal (mCDR) hotspot for climate change mitigation AI翻译
  作者：Chen, Xue- Wei-Jie; Zhang, Zhou; Pan, Miao- Jun; Liu, Yang; Li, Chang-Lin; Zhou, Yan Gen; Li, Li; Dong, Xuan; Dong, Yun-Wei; Li, Jing-Yu; Liu, Su-Mei; Wang, Xiao-Nan; Tian, Shuang- Jie; Liu, Yi; Zhang, Ji- Hong; Qiu, Yan- Guo; Wang, Xue-Gang; Cai, Wei- Jun; Tian, Xiang - Li; Kao, Shuh- Ji; Dong, Shuang- Lin
  作者单位：Ocean University of China; Ocean University of China; Hainan Tropical Ocean University; Ocean University of China; Chinese Academy of Fishery Sciences; Yellow Sea Fisheries Research Institute, CAFS; University of Delaware; Hainan University
  摘要：Bivalve farming, a vital component of global aquaculture, has been proposed as a potential marine carbon dioxide removal (mCDR) strategy, yet its role remains contentious. Using field mesocosms, we demonstrate that oyster filter- feeding enhances mCDR by accelerating the formation of particulate and dissolved organic carbon in the water column and promoting organic carbon deposition in sediments. This process shifts the water column toward a more autotrophic and alkaline state, effectively seq...
• Upscaling behavioral interventions requires addressing selection bias AI翻译
  作者：Loh, Wen Wei; Ren, Dongning
  作者单位：Maastricht University; Maastricht University
• Unprecedented suppression of Panama's Pacific upwelling in 2025 AI翻译
  作者：O'Dea, Aaron; Sellers, Andrew J.; Perez- Medina, Carmen; Diaz, Javier Pardo; Bloise, Alexandra Guzman; Pohlker, Christopher; Chilinski, Michal T.; Aardema, Hedy M.; Cybulski, Jonathan D.; Heins, Lena; Paton, Steven R.; Slagter, Hans A.; Schiebel, Ralf; Haug, Gerald H.
  作者单位：Smithsonian Institution; Smithsonian Tropical Research Institute; Secretaria Nacional de Ciencia, Tecnologia e Innovacin (SENACYT); Max Planck Society; University of Warsaw; Max Planck Society; University of Hong Kong
  摘要：The Gulf of Panama's (GOP) seasonal upwelling system has consistently delivered cool, nutrient-rich waters via northerly trade winds every January-April for at least 40 y. Here, we document the failure of this normally highly predictable phenomenon in 2025. Data suggest that the cause was a reduction in Panama wind-jet frequency, duration, and strength, possibly related to the Intertropical Convergence Zone (ITCZ) position during the 2024-2025 La Ni & ntilde;a, though the mechanisms remain unc...
• miR444b.2-HsfA1-AOC1 module mediates heat priming-enhanced blast resistance in rice AI翻译
  作者：Qiu, Jiehua; Cao, Xiuxiu; Shi, Huanbin; Chen, Zhengting; Zhang, Xiaoyu; Cao, Zijian; Huang, Dongmei; Wen, Hui; Chen, Ya; Kou, Yanjun
  作者单位：Chinese Academy of Agricultural Sciences; China National Rice Research Institute, CAAS; Hubei University
  摘要：As global climate change exacerbates extreme heat events, the interplay between heat stress and blast disease resistance in rice remains poorly understood. In this study, through integrated transcriptome profiling and systematic phenotyping of mutants in several thermosensory pathways, we identified HsfA1 as a positive regulator of heat priming-enhanced blast resistance in rice. Systematic analysis of microRNA (miRNA) dynamics, bioinformatics prediction, and RNA pull-down experiments revealed ...
• Topology and kinetic pathways of colloidosome assembly and disassembly AI翻译
  作者：Adkins, Raymond; Robaszewski, Joanna; Shin, Seungwoo; Brauns, Fridtjof; Jia, Leroy; Khanra, Ayantika; Sharma, Prerna; Pelcovits, Robert A.; Powers, Thomas R.; Dogic, Zvonimir
  作者单位：University of California System; University of California Santa Barbara; Yale University; United States Department of Defense; United States Army; U.S. Army Corps of Engineers; U.S. Army Engineer Research & Development Center (ERDC); ERDC - Risk Modeling; University of California System; University of California Santa Barbara; National Institute of Standards & Technology (NIST) - USA; Indian Institute of Science (IISC) - Bangalore; Indian Institute of Science (IISC) - Bangalore; Brown University; Brown University
  摘要：Closed capsules, such as lipid vesicles, soap bubbles, and emulsion droplets, are ubiquitous throughout biology, engineered matter, and everyday life. Their creation and disintegration are defined by a singularity that separates a topologically distinct extended liquid film from a boundary-free closed shell. Such topology-changing processes are of fundamental interest. They are also essential for intercellular transport, transcellular communication, and drug delivery. However, studies of vesic...
• Long- term history of continental weathering and particle transport to the sea AI翻译
  作者：Canfield, Don E.; Zhang, Shuichang; Mitchell, Ross N.; Wang, Xiaomei; Naemi, Amin; Spencer, Christopher J.; Zhang, Pengyaun
  作者单位：University of Southern Denmark; China National Petroleum Corporation; Chinese Academy of Sciences; Nanjing Institute of Geology & Paleontology, CAS; Institute of Geology & Geophysics, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Queens University - Canada
  摘要：Here, we explore the long-term history of chemical weathering and particle transport from the continents to the oceans by leveraging the histories of Zr/Al, Rb/Al, and Na/Al in marine sediments over the last 2000 My. We interpret these data in the context of elemental behavior in modern weathering environments and modern marine sediments. We find that from 2000 Mya to ca. 650 Mya, physical erosion was effective, where braided rivers efficiently delivered particles from land to the sea. Overall...
• PD-1 expression identifies proliferating malignant CLL B cells and is a potential biomarker of response to BTK inhibitor therapy AI翻译
  作者：Chang, Andres; Pelletier, Adam N.; McGuire, Donald J.; Tsagiopoulou, Maria; Karipidou, Maria; Ayers, Amy; Leal, Alyssa M. K.; Churnetski, Michael C.; O'Leary, Colin B.; Switchenko, Jeffrey M.; Davis, Carl; Frank, David A.; Koff, Jean L.; Cohen, Jonathon B.; Sekaly, Rafick P.; Stamatopoulos, Kostas; Flowers, Christopher R.; Ahmed, Rafi
  作者单位：University of Texas System; UTMD Anderson Cancer Center; Emory University; Emory University; Emory University; Rollins School Public Health
  摘要：Chronic lymphocytic leukemia (CLL) remains incurable despite treatment advances, and a major challenge is that biomarkers that predict response and resistance to current therapies are lacking. We report that activated and proliferating malignant CLL B cells in circulation express PD-1, a protein normally expressed in T cells. PD-1 expression is absent in circulating B cells from healthy controls and nonmalignant B cells from patients with CLL. Circulating PD-1+ CLL cells are found in all treat...