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作者：Schibler, Ueli; Sinturel, Flore; Naef, Felix; Gerber, Alan; Gatfield, David
作者单位：University of Geneva; Swiss School of Public Health (SSPH+); Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Vrije Universiteit Amsterdam; Vrije Universiteit Amsterdam; University of Amsterdam; University of Lausanne
摘要：In mammals, a hierarchically organized circadian timing system orchestrates daily rhythms of nearly all physiology. A master pacemaker in the brain's suprachiasmatic nucleus (SCN) synchronizes subsidiary clocks in most peripheral organs. By driving anabolic and catabolic cycles of proteins, lipids, and carbohydrates and by detoxifying endo-and xenobiotic components, the liver plays an important role in adapting the metabolic needs to rest-activity rhythms. In keeping with these functions, the ...
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作者：Adelmann, Charles H.; Venkatachalam, Avanthika; Huang, Lingjuan; Liu, Michelle; Germana, Sharon; Harry, Stefan A.; Rosen, Paul C.; Herron, Joshua; Tien, Pei- Chieh; Bar-Peled, Liron; Sabatini, David M.; Fisher, David E.
作者单位：Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Czech Academy of Sciences; Institute of Organic Chemistry & Biochemistry of the Czech Academy of Sciences
摘要：While it has been appreciated for decades that lysosomes can import cysteine, its significance for whole- organism physiology has remained uncertain. Recent work identified MFSD12 as a transmembrane protein required for cysteine import into lysosomes (and melanosomes), enabling genetic interrogation of this pathway. Here, we show that Mfsd12 knockout mice die between embryonic days 10.5 and 12.5, indicating that MFSD12 is essential for organogenesis. Mfsd12 loss results in the expression of ge...
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作者：Rowntree, Louise C.; Allen, Lilith F.; Hagen, Ruth R.; McQuilten, Hayley A.; Quadeer, Ahmed A.; Chaurasia, Priyanka; Kaewpreedee, Prathanporn; Lee, Kelly W. K.; Cohen, Carolyn A.; Petersen, Jan; Littler, Dene R.; Habel, Jennifer R.; Zhang, Wuji; Cheng, Samuel M. S.; Chan, Ken Ka Pang; Kwok, Janette S. Y.; Leung, Kathy S. M.; Wu, Joseph T.; Lee, Cheuk-Kwong; Davies, Jane; Pannaraj, Pia S.; Allen, E. Kaity; Thomas, Paul G.; Tosif, Shidan; Crawford, Nigel W.; Lappas, Martha; Thevarajan, Irani; Lewin, Sharon R.; Kent, Stephen J.; Juno, Jennifer A.; Bond, Katherine A.; Williamson, Deborah A.; Holmes, Natasha E.; Smibert, Olivia C.; Gordon, Claire L.; Trubiano, Jason A.; Kotsimbos, Tom C.; Cheng, Allen C.; Efstathiou, Claudia; Turtle, Lance; Thwaites, Ryan S.; Brightling, Christopher E.; Rossjohn, Jamie; McKay, Matthew R.; Tian, Jinmin; Liu, William Jun; Gao, George Fu; Xu, Jianqing; Sonehara, Kyuto; Ishii, Ken J.; Namkoong, Ho; Okada, Yukinori; Peiris, Malik; Hui, David S. C.; Poon, Leo L. M.; Doherty, Peter C.; Nguyen, Thi H. O.; Valkenburg, Sophie A.; Kedzierska, Katherine
作者单位：University of Melbourne; Peter Doherty Institute; Hong Kong University of Science & Technology; University of Melbourne; Monash University; Monash University; University of Hong Kong; HKU Pasteur Research Pole; University of Hong Kong; Prince of Wales Hospital Hong Kong; Chinese University of Hong Kong; Chinese University of Hong Kong; University of Hong Kong; University of Hong Kong; University of Hong Kong; Charles Darwin University; Menzies School of Health Research; Children's Hospital Los Angeles; University of California System; University of California Los Angeles; St Jude Children's Research Hospital; Murdoch Children's Research Institute; University of Melbourne; Royal Children's Hospital Melbourne; Royal Children's Hospital Melbourne; University of Melbourne; University of Melbourne; Peter Doherty Institute; Melbourne Health; University of Melbourne; Royal Melbourne Hospital; Peter Doherty Institute; Florey Institute of Neuroscience & Mental Health; Howard Florey Institute Affiliates; Monash University; University of Melbourne; Alfred Health; Monash University; Melbourne Sexual Health Centre; Victorian Infectious Diseases Reference Laboratory; University of Melbourne; Peter Doherty Institute; Melbourne Health; Royal Melbourne Hospital; University of St Andrews; Florey Institute of Neuroscience & Mental Health; Austin Research Institute; Howard Florey Institute Affiliates; Austin Research Institute; Florey Institute of Neuroscience & Mental Health; Howard Florey Institute Affiliates; University of Melbourne; Florey Institute of Neuroscience & Mental Health; Austin Research Institute; Howard Florey Institute Affiliates; Peter Maccallum Cancer Center; Peter Maccallum Cancer Center; Florey Institute of Neuroscience & Mental Health; Howard Florey Institute Affiliates; Monash University; Florey Institute of Neuroscience & Mental Health; Howard Florey Institute Affiliates; Monash Medical Centre; Monash University; Monash Health; Monash University; Monash University; Imperial College London; University of Liverpool; University of Leicester; Cardiff University; Chinese Center for Disease Control & Prevention; National Institute for Viral Disease Control & Prevention, Chinese Center for Disease Control & Prevention; Fudan University; Fudan University; University of Osaka; University of Tokyo; University of Tokyo; University of Osaka; Keio University; RIKEN; University of Osaka; Hokkaido University
摘要：Understanding host factors driving asymptomatic versus severe disease outcomes is of key importance if we are to control emerging and re-emerging viral infections. HLA-B*15:01 has been associated with asymptomatic SARS-CoV-2 infection in nonhospitalized individuals of European ancestry, with protective immunity attributed to preexisting cross-reactive CD8(+) T-cells directed against HLA-B*15:01-restricted Spike-derived S919-927 peptide (B15/S(919)(+)CD8(+) T-cells). However, fundamental questi...
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作者：Yao, Ze-Fan; Lim, Sujeung; Kuang, Yuyao; Lundqvist, Emil M.; Celt, Natalie; Chung, Caleb O.; Lee, Kathryn K.; Nguyen, Krystal; Le, Lanie; Tang, Sheng Wei; Milligan, Griffin M.; Kohl, Phillip; Sudarshan, Tarunya Rao; Li, Youli; Eguchi, Asuka; Paravastu, Anant K.; Zaragoza, Michael V.; Fishman, Dmitry A.; Ardona, Herdeline Ann M.
作者单位：University of California System; University of California Irvine; University of California System; University of California Irvine; University of California System; University of California Irvine; University of California System; University of California Santa Barbara; University System of Georgia; Georgia Institute of Technology; University of California System; University of California Irvine; University of California System; University of California Irvine; University System of Georgia; Georgia Institute of Technology
摘要：Charge and energy transport within living systems are fundamental processes that enable the autonomous function of excitable cells and tissues. To date, localized control of these transport processes has been enabled by genetic modification approaches to render light sensitivity to cells. Here, we present peptidic nanoassemblies as constituents of a cardiac biomaterial platform that leverages complementary sequence interactions to direct photoinduced energy transport at the cellular interface....
